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Smoking Cessation: full-pipeline trial registry
57 of 189 indexed Smoking Cessation trials are currently recruiting.
Corpus placement: #57 of 28,707 conditions by registered trial count.
189 US clinical trials · 57 currently recruiting · #57 of 28,707 conditions by registered trial count
Smoking Cessation: 189 US clinical trials tracked, 57 recruiting.
Smoking Cessation is the subject of 189 registered US clinical trials on ClinicalTrials.gov, 57 of them currently open to new participants. 33 are in Phase 3-4 (later-stage) and 30 in Phase 1-2 (earlier-stage). The most active sponsor is University of California, San Francisco, running 10 of these trials.
Enrollment posture brief
Registry condition smoking-cessation
OPEN 57 | RECR 30% | LATE 33 | EARLY 30 | RANK #57 | SPON 10
Volume-matched condition peers
Nearest open-share peer: Heart Diseases (30% recruiting · 86 trials)
Smoking Cessation lists 57 open slots (30% of 189 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Smoking Cessation on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Smoking Cessation is recruiting below its size-band peers.
57 of 189 indexed trials (30.2%) are open to enrollment, against a 37.1% average across 139 conditions with 100+ trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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Sponsorship of Smoking Cessation trials is spread across many organizations.
University of California, San Francisco accounts for 10 of 189 trials (5.3%). 84 distinct sponsors appear on at least one study for this condition label.
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Typical Smoking Cessation enrolment sits around 200 participants.
Median target enrolment is 200 among the 189 trials that report a genuine target (sentinel values excluded). 71 of those (37.6%) plan for fewer than 100 participants.
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Smoking Cessation research is mostly interventional.
181 interventional and 8 observational studies make up this index (95.8% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
189 total, page 4 of 4
Increasing Cessation Motivation and Treatment Engagement Among Smokers in Pain
Syracuse University
NCT03996902
A Phase I Study to Evaluate the Pharmacokinetics of Multiple Doses of Varenicline in Healthy Adolescent Smokers
Pfizer
NCT00463918
Integrating the Quit and Stay Quit Monday Model Into Smoking Cessation Services for Smokers With Mental Health Conditions
NYU Langone Health
NCT04512248
Intervention for Support Persons to Help Smokers Quit
Mayo Clinic
NCT00379054
Supplemental Nicotine Administration for Smoking Cessation in Posttraumatic Stress Disorder (PTSD)
Duke University
NCT01055886
Helping Moms Who Smoke
University of Kansas Medical Center
NCT03104452
Connecting Alaska Native People to Quit Smoking
Mayo Clinic
NCT03645941
Development and Pilot Testing of the Sense2Quit App
Columbia University
NCT05609032
AXS-05 Phase II Trial on Smoking Behavior
James Davis
NCT03471767
End Nicotine Dependence Clinic
Case Comprehensive Cancer Center
NCT03290430
A Multiple Health Behavior Change Intervention for Overweight and Obese Smokers
Brown University
NCT05136430
Tobacco Treatment Comparison for Cancer Care
University of Wisconsin, Madison
NCT06218823
Impact of E-cigarette Nicotine Concentration on Compensation
University of Kansas Medical Center
NCT05887947
Applying mHealth to Tobacco-related Health Disparities
H. Lee Moffitt Cancer Center and Research Institute
NCT03404596
Hospital-based Patient Navigation and Smoking Cessation
Boston Medical Center
NCT03452371
Smoking, Stress & Allopregnanolone Response
University of Minnesota
NCT02087800
VIDeOS for Smoking Cessation
Medical University of South Carolina
NCT06307496
Novel Treatment to Enhance Smoking Cessation Before Cancer Surgery
Yale University
NCT02402023
Varenicline for Treatment of E-cigarette Dependence
Yale University
NCT05541497
Treating Smokers With Mental Illness
University of Minnesota
NCT03822416
Proof-Of-Concept Investigation With a Neurosteroid Analog (Ganaxolone) as a Smoking Cessation Candidate
Jed E. Rose
NCT01857531
Contingency Management, Quitting Smoking, and ADHD
Duke University
NCT02266784
Preventing Postpartum Relapse to Smoking Using Yoga and Cognitive Behavioral Therapy: A Randomized Pilot Study
University of Pittsburgh
NCT00360581
Enhancing Relapse Prevention for Smoking Cessation With Repetitive Transcranial Magnetic Stimulation
The City College of New York
NCT02822703
Harnessing the Power of Technology: MOMBA for Postpartum Smoking
Yale University
NCT02237898
Varenicline and Smoking Cessation in Schizophrenia
University of Minnesota
NCT01111149
Randomized Pilot Study of a mHealth App for Ambivalent Smokers Living With HIV
Kaiser Permanente
NCT05339659
Smartphone-delivered Automated Video-assisted Smoking Treatment for Patrons of a Food Resource Center
University of Oklahoma
NCT03060278
Empowering LGBTQ+ Tobacco Cessation Pilot
University of Oklahoma
NCT05365633
Mobile Contingency Management for Smoking Cessation (R01 Supplement) (PrevailGO)
University of Oklahoma
NCT03517397
Stanford Tobacco Treatment Services - Virtual Reality Treatment for Smoking Cessation
Stanford University
NCT05220254
Tobacco Cessation in Public Housing
Johns Hopkins University
NCT04889638
SmokefreeSGM, A Text-based Smoking Cessation Intervention for Sexual and Gender Minority Groups
The University of Texas Health Science Center, Houston
NCT05029362
Mindfulness Based Smoking Cessation Program
Boston Medical Center
NCT02795312
Suvorexant to Reduce Symptoms of Nicotine Use
The University of Texas Health Science Center, Houston
NCT04234997
Smoking by IV Pulsed Nicotine
Yale University
NCT04488744
HCV-Smoking Cessation Study
Prisma Health-Upstate
NCT05466981
Designing an Implementation Strategy for Lung Screening and Smoking Cessation Treatment in Community Health Centers
University of Colorado, Denver
NCT05447897
Ketamine and Motivational Enhancement Therapy for the Treatment of Tobacco Use Disorder
Medical University of South Carolina
NCT05796791
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 15 |
| Phase 2 | 15 |
| Phase 3 | 14 |
| Phase 4 | 19 |
Top Sponsors
Named interventions
Most-linked intervention names on Smoking Cessation records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Smoking Cessation trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Smoking Cessation page
189 registered trials, 57 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 57 Smoking Cessation trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- University of California, San Francisco sponsors the most Smoking Cessation trials on record, review their full trial history before evaluating a specific study. See University of California, San Francisco's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Smoking Cessation condition card totals 189 registered trials; most-linked intervention Varenicline; top US site state California. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.