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Smoking Cessation clinical trials
57 of 189 indexed Smoking Cessation trials are currently recruiting.
189 US clinical trials · 57 currently recruiting
Smoking Cessation is the subject of 189 registered US clinical trials on ClinicalTrials.gov, 57 of them currently open to new participants. 33 are in Phase 3-4 (later-stage) and 30 in Phase 1-2 (earlier-stage). The most active sponsor is University of California, San Francisco, running 10 of these trials.
The research picture
Smoking Cessation has 189 registered US clinical trials, 57 of them open to new participants right now, about 30% of the total.
- 57
- recruiting participants now
- 30%
- of trials open to enrollment
- 33
- in Phase 3–4 (later-stage)
- 10
- top sponsor: University of California, San Francisco
Active & Recent Trials
189 total, page 4 of 4
Increasing Cessation Motivation and Treatment Engagement Among Smokers in Pain
Syracuse University
NCT03996902
A Phase I Study to Evaluate the Pharmacokinetics of Multiple Doses of Varenicline in Healthy Adolescent Smokers
Pfizer
NCT00463918
Integrating the Quit and Stay Quit Monday Model Into Smoking Cessation Services for Smokers With Mental Health Conditions
NYU Langone Health
NCT04512248
Intervention for Support Persons to Help Smokers Quit
Mayo Clinic
NCT00379054
Supplemental Nicotine Administration for Smoking Cessation in Posttraumatic Stress Disorder (PTSD)
Duke University
NCT01055886
Helping Moms Who Smoke
University of Kansas Medical Center
NCT03104452
Connecting Alaska Native People to Quit Smoking
Mayo Clinic
NCT03645941
Development and Pilot Testing of the Sense2Quit App
Columbia University
NCT05609032
AXS-05 Phase II Trial on Smoking Behavior
James Davis
NCT03471767
End Nicotine Dependence Clinic
Case Comprehensive Cancer Center
NCT03290430
A Multiple Health Behavior Change Intervention for Overweight and Obese Smokers
Brown University
NCT05136430
Tobacco Treatment Comparison for Cancer Care
University of Wisconsin, Madison
NCT06218823
Impact of E-cigarette Nicotine Concentration on Compensation
University of Kansas Medical Center
NCT05887947
Applying mHealth to Tobacco-related Health Disparities
H. Lee Moffitt Cancer Center and Research Institute
NCT03404596
Hospital-based Patient Navigation and Smoking Cessation
Boston Medical Center
NCT03452371
Smoking, Stress & Allopregnanolone Response
University of Minnesota
NCT02087800
VIDeOS for Smoking Cessation
Medical University of South Carolina
NCT06307496
Novel Treatment to Enhance Smoking Cessation Before Cancer Surgery
Yale University
NCT02402023
Varenicline for Treatment of E-cigarette Dependence
Yale University
NCT05541497
Treating Smokers With Mental Illness
University of Minnesota
NCT03822416
Proof-Of-Concept Investigation With a Neurosteroid Analog (Ganaxolone) as a Smoking Cessation Candidate
Jed E. Rose
NCT01857531
Contingency Management, Quitting Smoking, and ADHD
Duke University
NCT02266784
Preventing Postpartum Relapse to Smoking Using Yoga and Cognitive Behavioral Therapy: A Randomized Pilot Study
University of Pittsburgh
NCT00360581
Enhancing Relapse Prevention for Smoking Cessation With Repetitive Transcranial Magnetic Stimulation
The City College of New York
NCT02822703
Harnessing the Power of Technology: MOMBA for Postpartum Smoking
Yale University
NCT02237898
Varenicline and Smoking Cessation in Schizophrenia
University of Minnesota
NCT01111149
Randomized Pilot Study of a mHealth App for Ambivalent Smokers Living With HIV
Kaiser Permanente
NCT05339659
Smartphone-delivered Automated Video-assisted Smoking Treatment for Patrons of a Food Resource Center
University of Oklahoma
NCT03060278
Empowering LGBTQ+ Tobacco Cessation Pilot
University of Oklahoma
NCT05365633
Mobile Contingency Management for Smoking Cessation (R01 Supplement) (PrevailGO)
University of Oklahoma
NCT03517397
Stanford Tobacco Treatment Services - Virtual Reality Treatment for Smoking Cessation
Stanford University
NCT05220254
Tobacco Cessation in Public Housing
Johns Hopkins University
NCT04889638
SmokefreeSGM, A Text-based Smoking Cessation Intervention for Sexual and Gender Minority Groups
The University of Texas Health Science Center, Houston
NCT05029362
Mindfulness Based Smoking Cessation Program
Boston Medical Center
NCT02795312
Suvorexant to Reduce Symptoms of Nicotine Use
The University of Texas Health Science Center, Houston
NCT04234997
Smoking by IV Pulsed Nicotine
Yale University
NCT04488744
HCV-Smoking Cessation Study
Prisma Health-Upstate
NCT05466981
Designing an Implementation Strategy for Lung Screening and Smoking Cessation Treatment in Community Health Centers
University of Colorado, Denver
NCT05447897
Ketamine and Motivational Enhancement Therapy for the Treatment of Tobacco Use Disorder
Medical University of South Carolina
NCT05796791
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 15 |
| Phase 2 | 15 |
| Phase 3 | 14 |
| Phase 4 | 19 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Smoking Cessation Trial Landscape
189 indexed Smoking Cessation studies · 57 recruiting (30%).
Phase mix: 33 late (III/IV) vs 30 early (I/II).
Top sponsor: University of California, San Francisco (10 trials), 9 others listed. 39 shown below, recruiting first.
How to read this condition's trial landscape
That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Smoking Cessation?
PlainTrial tracks 189 US clinical trials for Smoking Cessation, of which 57 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Smoking Cessation?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.