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ClinicalTrials.gov 57 recruiting now official registry

Smoking Cessation clinical trials

57 of 189 indexed Smoking Cessation trials are currently recruiting.

189 US clinical trials · 57 currently recruiting

Smoking Cessation is the subject of 189 registered US clinical trials on ClinicalTrials.gov, 57 of them currently open to new participants. 33 are in Phase 3-4 (later-stage) and 30 in Phase 1-2 (earlier-stage). The most active sponsor is University of California, San Francisco, running 10 of these trials.

The research picture

Smoking Cessation has 189 registered US clinical trials, 57 of them open to new participants right now, about 30% of the total.

57
recruiting participants now
30%
of trials open to enrollment
33
in Phase 3–4 (later-stage)
10
top sponsor: University of California, San Francisco
Phase 115Phase 215Phase 314Phase 419

Active & Recent Trials

189 total, page 4 of 4

COMPLETED NA 76 participants

Increasing Cessation Motivation and Treatment Engagement Among Smokers in Pain

Syracuse University

NCT03996902

COMPLETED Phase 1 73 participants

A Phase I Study to Evaluate the Pharmacokinetics of Multiple Doses of Varenicline in Healthy Adolescent Smokers

Pfizer

NCT00463918

COMPLETED NA 70 participants

Integrating the Quit and Stay Quit Monday Model Into Smoking Cessation Services for Smokers With Mental Health Conditions

NYU Langone Health

NCT04512248

COMPLETED Phase 1 70 participants

Intervention for Support Persons to Help Smokers Quit

Mayo Clinic

NCT00379054

COMPLETED NA 69 participants

Supplemental Nicotine Administration for Smoking Cessation in Posttraumatic Stress Disorder (PTSD)

Duke University

NCT01055886

COMPLETED 62 participants

Helping Moms Who Smoke

University of Kansas Medical Center

NCT03104452

COMPLETED NA 61 participants

Connecting Alaska Native People to Quit Smoking

Mayo Clinic

NCT03645941

COMPLETED NA 60 participants

Development and Pilot Testing of the Sense2Quit App

Columbia University

NCT05609032

COMPLETED Phase 2 58 participants

AXS-05 Phase II Trial on Smoking Behavior

James Davis

NCT03471767

COMPLETED Early Phase 1 56 participants

End Nicotine Dependence Clinic

Case Comprehensive Cancer Center

NCT03290430

COMPLETED NA 55 participants

A Multiple Health Behavior Change Intervention for Overweight and Obese Smokers

Brown University

NCT05136430

COMPLETED Phase 4 52 participants

Tobacco Treatment Comparison for Cancer Care

University of Wisconsin, Madison

NCT06218823

COMPLETED NA 52 participants

Impact of E-cigarette Nicotine Concentration on Compensation

University of Kansas Medical Center

NCT05887947

COMPLETED Early Phase 1 50 participants

Applying mHealth to Tobacco-related Health Disparities

H. Lee Moffitt Cancer Center and Research Institute

NCT03404596

COMPLETED NA 44 participants

Hospital-based Patient Navigation and Smoking Cessation

Boston Medical Center

NCT03452371

COMPLETED 43 participants

Smoking, Stress & Allopregnanolone Response

University of Minnesota

NCT02087800

COMPLETED NA 42 participants

VIDeOS for Smoking Cessation

Medical University of South Carolina

NCT06307496

COMPLETED NA 40 participants

Novel Treatment to Enhance Smoking Cessation Before Cancer Surgery

Yale University

NCT02402023

COMPLETED Phase 2 40 participants

Varenicline for Treatment of E-cigarette Dependence

Yale University

NCT05541497

COMPLETED Phase 2 38 participants

Treating Smokers With Mental Illness

University of Minnesota

NCT03822416

COMPLETED Phase 2 36 participants

Proof-Of-Concept Investigation With a Neurosteroid Analog (Ganaxolone) as a Smoking Cessation Candidate

Jed E. Rose

NCT01857531

COMPLETED Phase 1 33 participants

Contingency Management, Quitting Smoking, and ADHD

Duke University

NCT02266784

COMPLETED Phase 1 30 participants

Preventing Postpartum Relapse to Smoking Using Yoga and Cognitive Behavioral Therapy: A Randomized Pilot Study

University of Pittsburgh

NCT00360581

COMPLETED NA 29 participants

Enhancing Relapse Prevention for Smoking Cessation With Repetitive Transcranial Magnetic Stimulation

The City College of New York

NCT02822703

COMPLETED Phase 1 26 participants

Harnessing the Power of Technology: MOMBA for Postpartum Smoking

Yale University

NCT02237898

COMPLETED Phase 2 24 participants

Varenicline and Smoking Cessation in Schizophrenia

University of Minnesota

NCT01111149

COMPLETED NA 22 participants

Randomized Pilot Study of a mHealth App for Ambivalent Smokers Living With HIV

Kaiser Permanente

NCT05339659

COMPLETED Phase 4 20 participants

Smartphone-delivered Automated Video-assisted Smoking Treatment for Patrons of a Food Resource Center

University of Oklahoma

NCT03060278

COMPLETED NA 20 participants

Empowering LGBTQ+ Tobacco Cessation Pilot

University of Oklahoma

NCT05365633

COMPLETED NA 20 participants

Mobile Contingency Management for Smoking Cessation (R01 Supplement) (PrevailGO)

University of Oklahoma

NCT03517397

COMPLETED NA 20 participants

Stanford Tobacco Treatment Services - Virtual Reality Treatment for Smoking Cessation

Stanford University

NCT05220254

COMPLETED NA 18 participants

Tobacco Cessation in Public Housing

Johns Hopkins University

NCT04889638

COMPLETED NA 18 participants

SmokefreeSGM, A Text-based Smoking Cessation Intervention for Sexual and Gender Minority Groups

The University of Texas Health Science Center, Houston

NCT05029362

COMPLETED NA 18 participants

Mindfulness Based Smoking Cessation Program

Boston Medical Center

NCT02795312

COMPLETED Phase 2 14 participants

Suvorexant to Reduce Symptoms of Nicotine Use

The University of Texas Health Science Center, Houston

NCT04234997

COMPLETED Early Phase 1 13 participants

Smoking by IV Pulsed Nicotine

Yale University

NCT04488744

COMPLETED NA 10 participants

HCV-Smoking Cessation Study

Prisma Health-Upstate

NCT05466981

COMPLETED NA 9 participants

Designing an Implementation Strategy for Lung Screening and Smoking Cessation Treatment in Community Health Centers

University of Colorado, Denver

NCT05447897

COMPLETED Early Phase 1 7 participants

Ketamine and Motivational Enhancement Therapy for the Treatment of Tobacco Use Disorder

Medical University of South Carolina

NCT05796791

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Phase Distribution

PhaseTrial count
Phase 1 15
Phase 2 15
Phase 3 14
Phase 4 19

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Smoking Cessation Trial Landscape

189 indexed Smoking Cessation studies · 57 recruiting (30%).

Phase mix: 33 late (III/IV) vs 30 early (I/II).

Top sponsor: University of California, San Francisco (10 trials), 9 others listed. 39 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Smoking Cessation?

PlainTrial tracks 189 US clinical trials for Smoking Cessation, of which 57 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Smoking Cessation?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.