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ClinicalTrials.gov 76 recruiting now official registry

Schizophrenia clinical trials

76 of 318 indexed Schizophrenia trials are currently recruiting.

318 US clinical trials · 76 currently recruiting

Schizophrenia is the subject of 318 registered US clinical trials on ClinicalTrials.gov, 76 of them currently open to new participants. 90 are in Phase 3-4 (later-stage) and 87 in Phase 1-2 (earlier-stage). The most active sponsor is University of Maryland, Baltimore, running 14 of these trials.

The research picture

Schizophrenia has 318 registered US clinical trials, 76 of them open to new participants right now, about 24% of the total.

76
recruiting participants now
24%
of trials open to enrollment
90
in Phase 3–4 (later-stage)
14
top sponsor: University of Maryland, Baltimore
Phase 147Phase 240Phase 350Phase 440

Active & Recent Trials

318 total, page 6 of 7

COMPLETED NA 40 participants

Texting for Relapse Prevention

Center for Innovative Public Health Research

NCT02819349

COMPLETED Phase 2 40 participants

Safety, Tolerability, and Pharmacokinetics of OMS643762 in Psychiatrically Stable Schizophrenia Subjects

Omeros Corporation

NCT01952132

COMPLETED NA 40 participants

Confirmatory Efficacy Trial of a Gluten-Free Diet in a Subgroup of Persons With Schizophrenia Who Have High Levels of IgG Anti-Gliadin Antibodies (AGA IG)

University of Maryland, Baltimore

NCT03183609

COMPLETED Phase 3 40 participants

Self-Management Therapy for Youth With Schizophrenia

National Institute of Mental Health (NIMH)

NCT00000387

COMPLETED NA 40 participants

Peer-delivered and Technology-Assisted Integrated Illness Management and Recovery

Dartmouth-Hitchcock Medical Center

NCT04481737

COMPLETED NA 40 participants

Cognitive Remediation and Social Skills Training in Schizophrenia

The University of Texas Health Science Center at San Antonio

NCT00223535

COMPLETED Phase 1 40 participants

Study to Assess the Safety, Tolerability and Pharmacokinetics of Oral Brexpiprazole (OPC- 34712) in Adolescents With Schizophrenia

Otsuka Pharmaceutical Development & Commercialization

NCT02411695

COMPLETED Phase 1 39 participants

Multiple Dose Safety Study of PF-04802540 in Subjects With Schizophrenia

Taisho Pharmaceutical Co.

NCT00876304

COMPLETED Phase 1 39 participants

Electroconvulsive Therapy in Clozapine Refractory Schizophrenia

Northwell Health

NCT00042224

COMPLETED Phase 4 38 participants

Effects of Weekly Dosing of D-cycloserine on Cognitive Function in Individuals With Schizophrenia

Massachusetts General Hospital

NCT00455702

COMPLETED Phase 2 38 participants

Treating Smokers With Mental Illness

University of Minnesota

NCT03822416

COMPLETED 38 participants

Direct Measurements of Cardiometabolic Risk in Treated Schizophrenia Patients

Washington University School of Medicine

NCT00501163

COMPLETED Phase 4 38 participants

Effectiveness of Clozapine Versus Olanzapine for Treatment-resistant Schizophrenia

Harvard Medical School (HMS and HSDM)

NCT00169065

COMPLETED Phase 1 36 participants

Study to Determine the Pharmacokinetics, Safety & Tolerability of Aripiprazole in Adults With Schizophrenia

Otsuka Pharmaceutical Development & Commercialization

NCT03150771

COMPLETED NA 35 participants

Neurocognitive Effects of Ziprasidone: Relationship to Working Memory and Dopamine Blockade

Northwell Health

NCT00225498

COMPLETED Phase 1 35 participants

Study in Stabilized Schizophrenic Patients to Evaluate the Pharmacokinetics of Risperidone and 9-Hydroxy (OH)-Risperidone When Risperidone is Administered From a Polyurethane Implant

Endo Pharmaceuticals

NCT01774435

COMPLETED Phase 4 32 participants

Minocycline and Tobacco Craving in Smokers With Schizophrenia

University of Maryland, Baltimore

NCT02968602

COMPLETED NA 32 participants

A Comparison of Two Cognitive Batteries in People With Schizophrenia

North Suffolk Mental Health Association

NCT00499044

COMPLETED Phase 2 31 participants

A Study to Evaluate Multiple Oral Doses of Luvadaxistat in Adults With Schizophrenia

Neurocrine Biosciences

NCT03359785

COMPLETED NA 31 participants

Motivation and Skills Support (MASS)

Boston University Charles River Campus

NCT03404219

COMPLETED Phase 1 31 participants

A Clinical Study That Will Assess How Food Moves Through the Stomach and Effects Blood Glucose Levels in Subjects With Schizophrenia Taking SEP-363856 or and Prior Antipsychotic (PA) Standard

Otsuka Pharmaceutical Development & Commercialization

NCT05402111

COMPLETED Phase 1 31 participants

Assess the Safety and Pharmacokinetics of Ascending, Multiple Oral Doses of SPD489 in Adults With Schizophrenia

Shire

NCT01457339

COMPLETED NA 30 participants

Proactive Psychiatry Consultation for Patients With Cancer and Severe Mental Illness

Massachusetts General Hospital

NCT02594696

COMPLETED Phase 4 30 participants

Once-Daily Asenapine for Schizophrenia

Duke University

NCT01549041

COMPLETED NA 30 participants

A Concierge Model of CAE Plus LAI in Individuals With Schizophrenia at Risk for Treatment Non-adherence and Homelessness

University Hospitals Cleveland Medical Center

NCT02085447

COMPLETED Phase 2 28 participants

Efficacy of Pimozide Augmentation for Clozapine Partial Response

Yale University

NCT00374244

COMPLETED NA 28 participants

Pilot Study of Pregnenolone Augmentation Targeting Cognitive Symptoms in Persistently Symptomatic Patients With Schizophrenia

Durham VA Medical Center

NCT00560937

COMPLETED Phase 4 26 participants

Prebiotic Treatment in People With Schizophrenia - Pilot Study

University of Maryland, Baltimore

NCT03617783

COMPLETED NA 26 participants

Modafinil Augmentation Therapy for Excessive Daytime Sleepiness and Negative Symptoms in Patients With Schizophrenia

Veterans Medical Research Foundation

NCT00546403

COMPLETED NA 25 participants

Financial Incentives to Improve Medication Adherence

Northwell Health

NCT04191876

COMPLETED NA 25 participants

Effects of Eszopiclone on Sleep-dependent Learning in Schizophrenia

Massachusetts General Hospital

NCT00833547

COMPLETED NA 25 participants

Rt-fMRI Neurofeedback and AH in Schizophrenia

Harvard Medical School (HMS and HSDM)

NCT03504579

COMPLETED Phase 4 25 participants

Ramelteon as an Adjunct Therapy in Non-Diabetic Patients With Schizophrenia

Massachusetts General Hospital

NCT00595504

COMPLETED Phase 4 24 participants

Effects of Intranasal Oxytocin on Satiety Signaling in People With Schizophrenia

University of Maryland, Baltimore

NCT01614093

COMPLETED Phase 4 24 participants

Ziprasidone for Clozapine- or Olanzapine-Associated Diabetes Mellitus

North Suffolk Mental Health Association

NCT00351000

COMPLETED Phase 2 24 participants

Varenicline and Smoking Cessation in Schizophrenia

University of Minnesota

NCT01111149

COMPLETED NA 24 participants

Pilot Trial of Naltrexone for Obesity in Women With Schizophrenia

Yale University

NCT00793780

COMPLETED NA 23 participants

Impact of a Ketogenic Diet on Metabolic and Psychiatric Health in Patients With Bipolar or Schizophrenia Illness

Stanford University

NCT03935854

COMPLETED Phase 1 21 participants

A Clinical Trial Study to Determine the Effect of an Investigational Drug (SEP-363856) Has on the Way That the Drug Metformin Travels Through the Body in People With Schizophrenia.

Otsuka Pharmaceutical Development & Commercialization

NCT04865835

COMPLETED NA 21 participants

Neuroendocrine and Immune Response to Stress in Schizophrenia

University of Maryland, Baltimore

NCT01975584

COMPLETED Phase 4 21 participants

Comparison of Optimal Antipsychotic Treatments for Adults With Schizophrenia

National Institute of Mental Health (NIMH)

NCT00802100

COMPLETED NA 20 participants

NST-SPARK: Preliminary Study of an Augmented Reality (AR) App Delivering Recovery-Oriented Cognitive Therapy for Negative Symptoms in Schizophrenia

North Shore Therapeutics

NCT06653829

COMPLETED Phase 4 20 participants

Pilot Study of Atomoxetine To Enhance COgnition In Patients With Schizophrenia

Research Foundation for Mental Hygiene

NCT00488163

COMPLETED Phase 4 20 participants

Galantamine for Cognition in People With Schizophrenia

North Suffolk Mental Health Association

NCT00320736

COMPLETED NA 19 participants

Brain Stimulation and Cognitive Training - Efficacy

University of Michigan

NCT05111548

COMPLETED Phase 1 18 participants

M1 Schizophrenia PET Study

Yale University

NCT05105542

COMPLETED Phase 1 18 participants

A Positron Emission Tomography Study of SLV354 in Healthy Subjects and Subjects With Schizophrenia

Abbott

NCT01545310

COMPLETED 17 participants

In Vivo Imaging of Therapeutic Electric Current Flow

University of Florida

NCT02453763

COMPLETED Phase 2 16 participants

Gamma-Amino Butyric Acid (GABA)-A Alpha2/3 Study

University of Pittsburgh

NCT00129441

COMPLETED Phase 2 16 participants

Biomarkers in Schizophrenia

Nathan Kline Institute for Psychiatric Research

NCT00817336

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Phase Distribution

PhaseTrial count
Phase 1 47
Phase 2 40
Phase 3 50
Phase 4 40

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Schizophrenia Trial Landscape

318 indexed Schizophrenia studies · 76 recruiting (24%).

Phase mix: 90 late (III/IV) vs 87 early (I/II).

Top sponsor: University of Maryland, Baltimore (14 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Schizophrenia?

PlainTrial tracks 318 US clinical trials for Schizophrenia, of which 76 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Schizophrenia?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.