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Schizophrenia clinical trials
76 of 318 indexed Schizophrenia trials are currently recruiting.
318 US clinical trials · 76 currently recruiting
Schizophrenia is the subject of 318 registered US clinical trials on ClinicalTrials.gov, 76 of them currently open to new participants. 90 are in Phase 3-4 (later-stage) and 87 in Phase 1-2 (earlier-stage). The most active sponsor is University of Maryland, Baltimore, running 14 of these trials.
The research picture
Schizophrenia has 318 registered US clinical trials, 76 of them open to new participants right now, about 24% of the total.
- 76
- recruiting participants now
- 24%
- of trials open to enrollment
- 90
- in Phase 3–4 (later-stage)
- 14
- top sponsor: University of Maryland, Baltimore
Active & Recent Trials
318 total, page 6 of 7
Texting for Relapse Prevention
Center for Innovative Public Health Research
NCT02819349
Safety, Tolerability, and Pharmacokinetics of OMS643762 in Psychiatrically Stable Schizophrenia Subjects
Omeros Corporation
NCT01952132
Confirmatory Efficacy Trial of a Gluten-Free Diet in a Subgroup of Persons With Schizophrenia Who Have High Levels of IgG Anti-Gliadin Antibodies (AGA IG)
University of Maryland, Baltimore
NCT03183609
Self-Management Therapy for Youth With Schizophrenia
National Institute of Mental Health (NIMH)
NCT00000387
Peer-delivered and Technology-Assisted Integrated Illness Management and Recovery
Dartmouth-Hitchcock Medical Center
NCT04481737
Cognitive Remediation and Social Skills Training in Schizophrenia
The University of Texas Health Science Center at San Antonio
NCT00223535
Study to Assess the Safety, Tolerability and Pharmacokinetics of Oral Brexpiprazole (OPC- 34712) in Adolescents With Schizophrenia
Otsuka Pharmaceutical Development & Commercialization
NCT02411695
Multiple Dose Safety Study of PF-04802540 in Subjects With Schizophrenia
Taisho Pharmaceutical Co.
NCT00876304
Electroconvulsive Therapy in Clozapine Refractory Schizophrenia
Northwell Health
NCT00042224
Effects of Weekly Dosing of D-cycloserine on Cognitive Function in Individuals With Schizophrenia
Massachusetts General Hospital
NCT00455702
Treating Smokers With Mental Illness
University of Minnesota
NCT03822416
Direct Measurements of Cardiometabolic Risk in Treated Schizophrenia Patients
Washington University School of Medicine
NCT00501163
Effectiveness of Clozapine Versus Olanzapine for Treatment-resistant Schizophrenia
Harvard Medical School (HMS and HSDM)
NCT00169065
Study to Determine the Pharmacokinetics, Safety & Tolerability of Aripiprazole in Adults With Schizophrenia
Otsuka Pharmaceutical Development & Commercialization
NCT03150771
Neurocognitive Effects of Ziprasidone: Relationship to Working Memory and Dopamine Blockade
Northwell Health
NCT00225498
Study in Stabilized Schizophrenic Patients to Evaluate the Pharmacokinetics of Risperidone and 9-Hydroxy (OH)-Risperidone When Risperidone is Administered From a Polyurethane Implant
Endo Pharmaceuticals
NCT01774435
Minocycline and Tobacco Craving in Smokers With Schizophrenia
University of Maryland, Baltimore
NCT02968602
A Comparison of Two Cognitive Batteries in People With Schizophrenia
North Suffolk Mental Health Association
NCT00499044
A Study to Evaluate Multiple Oral Doses of Luvadaxistat in Adults With Schizophrenia
Neurocrine Biosciences
NCT03359785
Motivation and Skills Support (MASS)
Boston University Charles River Campus
NCT03404219
A Clinical Study That Will Assess How Food Moves Through the Stomach and Effects Blood Glucose Levels in Subjects With Schizophrenia Taking SEP-363856 or and Prior Antipsychotic (PA) Standard
Otsuka Pharmaceutical Development & Commercialization
NCT05402111
Assess the Safety and Pharmacokinetics of Ascending, Multiple Oral Doses of SPD489 in Adults With Schizophrenia
Shire
NCT01457339
Proactive Psychiatry Consultation for Patients With Cancer and Severe Mental Illness
Massachusetts General Hospital
NCT02594696
Once-Daily Asenapine for Schizophrenia
Duke University
NCT01549041
A Concierge Model of CAE Plus LAI in Individuals With Schizophrenia at Risk for Treatment Non-adherence and Homelessness
University Hospitals Cleveland Medical Center
NCT02085447
Efficacy of Pimozide Augmentation for Clozapine Partial Response
Yale University
NCT00374244
Pilot Study of Pregnenolone Augmentation Targeting Cognitive Symptoms in Persistently Symptomatic Patients With Schizophrenia
Durham VA Medical Center
NCT00560937
Prebiotic Treatment in People With Schizophrenia - Pilot Study
University of Maryland, Baltimore
NCT03617783
Modafinil Augmentation Therapy for Excessive Daytime Sleepiness and Negative Symptoms in Patients With Schizophrenia
Veterans Medical Research Foundation
NCT00546403
Financial Incentives to Improve Medication Adherence
Northwell Health
NCT04191876
Effects of Eszopiclone on Sleep-dependent Learning in Schizophrenia
Massachusetts General Hospital
NCT00833547
Rt-fMRI Neurofeedback and AH in Schizophrenia
Harvard Medical School (HMS and HSDM)
NCT03504579
Ramelteon as an Adjunct Therapy in Non-Diabetic Patients With Schizophrenia
Massachusetts General Hospital
NCT00595504
Effects of Intranasal Oxytocin on Satiety Signaling in People With Schizophrenia
University of Maryland, Baltimore
NCT01614093
Ziprasidone for Clozapine- or Olanzapine-Associated Diabetes Mellitus
North Suffolk Mental Health Association
NCT00351000
Varenicline and Smoking Cessation in Schizophrenia
University of Minnesota
NCT01111149
Pilot Trial of Naltrexone for Obesity in Women With Schizophrenia
Yale University
NCT00793780
Impact of a Ketogenic Diet on Metabolic and Psychiatric Health in Patients With Bipolar or Schizophrenia Illness
Stanford University
NCT03935854
A Clinical Trial Study to Determine the Effect of an Investigational Drug (SEP-363856) Has on the Way That the Drug Metformin Travels Through the Body in People With Schizophrenia.
Otsuka Pharmaceutical Development & Commercialization
NCT04865835
Neuroendocrine and Immune Response to Stress in Schizophrenia
University of Maryland, Baltimore
NCT01975584
Comparison of Optimal Antipsychotic Treatments for Adults With Schizophrenia
National Institute of Mental Health (NIMH)
NCT00802100
NST-SPARK: Preliminary Study of an Augmented Reality (AR) App Delivering Recovery-Oriented Cognitive Therapy for Negative Symptoms in Schizophrenia
North Shore Therapeutics
NCT06653829
Pilot Study of Atomoxetine To Enhance COgnition In Patients With Schizophrenia
Research Foundation for Mental Hygiene
NCT00488163
Galantamine for Cognition in People With Schizophrenia
North Suffolk Mental Health Association
NCT00320736
Brain Stimulation and Cognitive Training - Efficacy
University of Michigan
NCT05111548
M1 Schizophrenia PET Study
Yale University
NCT05105542
A Positron Emission Tomography Study of SLV354 in Healthy Subjects and Subjects With Schizophrenia
Abbott
NCT01545310
In Vivo Imaging of Therapeutic Electric Current Flow
University of Florida
NCT02453763
Gamma-Amino Butyric Acid (GABA)-A Alpha2/3 Study
University of Pittsburgh
NCT00129441
Biomarkers in Schizophrenia
Nathan Kline Institute for Psychiatric Research
NCT00817336
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 47 |
| Phase 2 | 40 |
| Phase 3 | 50 |
| Phase 4 | 40 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Schizophrenia Trial Landscape
318 indexed Schizophrenia studies · 76 recruiting (24%).
Phase mix: 90 late (III/IV) vs 87 early (I/II).
Top sponsor: University of Maryland, Baltimore (14 trials), 9 others listed. 50 shown below, recruiting first.
How to read this condition's trial landscape
That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Schizophrenia?
PlainTrial tracks 318 US clinical trials for Schizophrenia, of which 76 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Schizophrenia?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.