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Schizophrenia clinical trials
76 of 318 indexed Schizophrenia trials are currently recruiting.
318 US clinical trials · 76 currently recruiting
Schizophrenia is the subject of 318 registered US clinical trials on ClinicalTrials.gov, 76 of them currently open to new participants. 90 are in Phase 3-4 (later-stage) and 87 in Phase 1-2 (earlier-stage). The most active sponsor is University of Maryland, Baltimore, running 14 of these trials.
The research picture
Schizophrenia has 318 registered US clinical trials, 76 of them open to new participants right now, about 24% of the total.
- 76
- recruiting participants now
- 24%
- of trials open to enrollment
- 90
- in Phase 3–4 (later-stage)
- 14
- top sponsor: University of Maryland, Baltimore
Active & Recent Trials
318 total, page 5 of 7
Development of a Mobile Heath Augmented Brief Suicide Prevention Intervention for People With SMI
University of California, San Diego
NCT03198364
Social Cognitive Training for Psychosis: Treatment Development
Yale University
NCT01579422
Ziprasidone for Improving Insulin Sensitivity in People With Schizophrenia Who Are at Risk for Diabetes
Veterans Medical Research Foundation
NCT00338949
Cognitive - Behavioral Therapy
US Department of Veterans Affairs
NCT00018629
Relationship Between Neurotransmitter Receptor Polymorphisms, Plasma Concentrations and Clinical Response to Clozapine
Delwyn D. Miller
NCT00581932
Treatment of Mania Symptoms With Drug Therapy
Palo Alto Veterans Institute for Research
NCT00183443
Metabolic Signatures and Biomarkers in Schizophrenia
Duke University
NCT00466310
Cognitive Training for Patients With Schizophrenia
University of California, San Diego
NCT01521026
Safety, Tolerability, Pharmacokinetics and Efficacy of 180 mg Subcutaneous Risperidone From 6 mg Oral Risperidone
Indivior
NCT03978832
A Study of the Effects of Sarcosine on Symptoms and Brain Glycine Levels in People With Schizophrenia
Massachusetts General Hospital
NCT00538070
Improving Accessibility and Personalization of CR for Schizophrenia
New York State Psychiatric Institute
NCT03576976
Study in Stabilized Schizophrenic Patients to Evaluate the Pharmacokinetics of Risperidone and 9-Hydroxy (OH)-Risperidone When Risperidone is Administered From a Polyurethane Implant
Braeburn Pharmaceuticals
NCT02658357
Double-Blind Trial of a Probiotic Supplement to Reduce the Symptoms of Schizophrenia
Sheppard Pratt Health System
NCT01242371
Determining the Effects of Risperdal Consta in Patients With Psychotic Disorders and Incomplete Adherence
Duke University
NCT00215579
Memantine Augmentation of Targeted Cognitive Training in Schizophrenia
University of California, San Diego
NCT04857983
A System for Preference Assessment in Mental Health
University of California, Los Angeles
NCT02183844
Web-Based Weight Management for Individuals With Mental Illness
University of California, Los Angeles
NCT01324973
The Effect of N-Acetyl Cysteine on Cortical Erosion in Early Stage Schizophrenia
Indiana University
NCT01339858
High Dose of Quetiapine in Treating Subjects With Treatment Refractory Schizophrenia or Schizoaffective Disorder
Manhattan Psychiatric Center
NCT00297947
A Clinical Study to Learn if SEP-363856 Has Physical Dependence in Adults With Schizophrenia
Otsuka Pharmaceutical Development & Commercialization
NCT05848700
Effects of Pravastatin on Cholesterol, Inflammation and Cognition in Schizophrenia
Massachusetts General Hospital
NCT01082588
Aripiprazole Oral Acceptability Trial
Otsuka Pharmaceutical Development & Commercialization
NCT00101569
The Effects AZD8529 on Cognition and Negative Symptoms in Schizophrenics
AstraZeneca
NCT00986531
In-person vs. Remote Wellness Support
The University of Texas Health Science Center at San Antonio
NCT04526067
Life Goals Behavioral Change to Improve Outcomes for Veterans With Serious Mental Illness
VA Office of Research and Development
NCT01244854
Benefits of Physical Exercise in Schizophrenia
VA Office of Research and Development
NCT02716584
A Study to Evaluate the Overall Effects of Treatment With Abbreviated CT-156 in People With Schizophrenia
Click Therapeutics
NCT06136936
Study to Demonstrate Cognitive Enhancing Effects of BF2.649
University of Texas Southwestern Medical Center
NCT00690274
Treatment of Cognitive and Negative Symptoms in Schizophrenia With N-acetylcysteine
University of California, Los Angeles
NCT02505477
Development of a Mobile System for Self-management of Schizophrenia (SOS)
Dartmouth-Hitchcock Medical Center
NCT01969500
Controlled Trial of Brexpiprazole For The Treatment of Co-occurring Schizophrenia and Substance Use Disorder
University of Massachusetts, Worcester
NCT03526354
Do Self-Report and Physician Impressions of Adherence to Oral Antipsychotic Medication Agree With Objective Data?
The University of Texas Health Science Center at San Antonio
NCT00223522
Transcranial Magnetic Stimulation (TMS) Treatment for Patients With Persistent Auditory Hallucinations
Yale University
NCT00042159
Omega-3 Dietary Supplements in Schizophrenia
Delbert Robinson
NCT01786239
Effectiveness of a Mobile Texting Intervention for People With Serious Mental Illness
University of Washington
NCT03062267
Exploratory Study of a Digital Therapeutics in People With Schizophrenia
Click Therapeutics
NCT05438160
Enhancing Cognitive Training Through Exercise After a First Schizophrenia Episode
University of California, Los Angeles
NCT02267070
A Study to Determine Pharmacokinetic Characteristics of LY03010 Versus INVEGA SUSTENNA® in Schizophrenia Patients
Luye Pharma Group
NCT03751488
Levetiracetam in Early Psychosis
NYU Langone Health
NCT03129360
Safety and Tolerability Study of Lu AF11167 After Repeated Dosing in Patients With Schizophrenia
H. Lundbeck A/S
NCT02202213
Using Transcranial Magnetic Stimulation (TMS) to Understand 'Negative' Symptoms of Schizophrenia
Beth Israel Deaconess Medical Center
NCT03648268
A Study of Aripiprazole Lauroxil in Subjects With Schizophrenia or Schizoaffective Disorder
Alkermes
NCT02636842
Folate Supplementation in Schizophrenia
Massachusetts General Hospital
NCT00249288
Comparative Effects of Chronic Treatment With Olanzapine and Risperidone on Glucose and Lipid Metabolism
Nathan Kline Institute for Psychiatric Research
NCT00287820
D-serine Augmentation of Neuroplasticity
New York State Psychiatric Institute
NCT03711500
Single Ascending Dose Study of RBP-7000
Indivior
NCT02768649
Antipsychotics and Blood Vessel Function
Jess G. Fiedorowicz
NCT00585273
Effects of Smoking Cues on Tobacco Craving Responses and the Reinforcing Efficacy of Cigarettes in Smokers With and Without Schizophrenia
University of Maryland, Baltimore
NCT00770237
PK, Safety, and Tolerability Study of RBP-7000 of Different Molecular Weight Polymer in Subjects With Schizophrenia
Indivior
NCT02687984
Atomoxetine for Treatment of Weight Gain in Olanzapine or Clozapine Patients
University of Maryland, Baltimore
NCT00176436
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 47 |
| Phase 2 | 40 |
| Phase 3 | 50 |
| Phase 4 | 40 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Schizophrenia Trial Landscape
318 indexed Schizophrenia studies · 76 recruiting (24%).
Phase mix: 90 late (III/IV) vs 87 early (I/II).
Top sponsor: University of Maryland, Baltimore (14 trials), 9 others listed. 50 shown below, recruiting first.
How to read this condition's trial landscape
That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Schizophrenia?
PlainTrial tracks 318 US clinical trials for Schizophrenia, of which 76 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Schizophrenia?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.