Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.

ClinicalTrials.gov 76 recruiting now official registry

Schizophrenia clinical trials

76 of 318 indexed Schizophrenia trials are currently recruiting.

318 US clinical trials · 76 currently recruiting

Schizophrenia is the subject of 318 registered US clinical trials on ClinicalTrials.gov, 76 of them currently open to new participants. 90 are in Phase 3-4 (later-stage) and 87 in Phase 1-2 (earlier-stage). The most active sponsor is University of Maryland, Baltimore, running 14 of these trials.

The research picture

Schizophrenia has 318 registered US clinical trials, 76 of them open to new participants right now, about 24% of the total.

76
recruiting participants now
24%
of trials open to enrollment
90
in Phase 3–4 (later-stage)
14
top sponsor: University of Maryland, Baltimore
Phase 147Phase 240Phase 350Phase 440

Active & Recent Trials

318 total, page 5 of 7

COMPLETED NA 78 participants

Development of a Mobile Heath Augmented Brief Suicide Prevention Intervention for People With SMI

University of California, San Diego

NCT03198364

COMPLETED Phase 1 77 participants

Social Cognitive Training for Psychosis: Treatment Development

Yale University

NCT01579422

COMPLETED Phase 4 77 participants

Ziprasidone for Improving Insulin Sensitivity in People With Schizophrenia Who Are at Risk for Diabetes

Veterans Medical Research Foundation

NCT00338949

COMPLETED Phase 2 76 participants

Cognitive - Behavioral Therapy

US Department of Veterans Affairs

NCT00018629

COMPLETED 76 participants

Relationship Between Neurotransmitter Receptor Polymorphisms, Plasma Concentrations and Clinical Response to Clozapine

Delwyn D. Miller

NCT00581932

COMPLETED Phase 3 75 participants

Treatment of Mania Symptoms With Drug Therapy

Palo Alto Veterans Institute for Research

NCT00183443

COMPLETED Phase 1 71 participants

Metabolic Signatures and Biomarkers in Schizophrenia

Duke University

NCT00466310

COMPLETED NA 69 participants

Cognitive Training for Patients With Schizophrenia

University of California, San Diego

NCT01521026

COMPLETED Phase 4 69 participants

Safety, Tolerability, Pharmacokinetics and Efficacy of 180 mg Subcutaneous Risperidone From 6 mg Oral Risperidone

Indivior

NCT03978832

COMPLETED NA 68 participants

A Study of the Effects of Sarcosine on Symptoms and Brain Glycine Levels in People With Schizophrenia

Massachusetts General Hospital

NCT00538070

COMPLETED NA 67 participants

Improving Accessibility and Personalization of CR for Schizophrenia

New York State Psychiatric Institute

NCT03576976

COMPLETED Phase 2 66 participants

Study in Stabilized Schizophrenic Patients to Evaluate the Pharmacokinetics of Risperidone and 9-Hydroxy (OH)-Risperidone When Risperidone is Administered From a Polyurethane Implant

Braeburn Pharmaceuticals

NCT02658357

COMPLETED NA 65 participants

Double-Blind Trial of a Probiotic Supplement to Reduce the Symptoms of Schizophrenia

Sheppard Pratt Health System

NCT01242371

COMPLETED Phase 4 64 participants

Determining the Effects of Risperdal Consta in Patients With Psychotic Disorders and Incomplete Adherence

Duke University

NCT00215579

COMPLETED Phase 2 62 participants

Memantine Augmentation of Targeted Cognitive Training in Schizophrenia

University of California, San Diego

NCT04857983

COMPLETED NA 61 participants

A System for Preference Assessment in Mental Health

University of California, Los Angeles

NCT02183844

COMPLETED NA 60 participants

Web-Based Weight Management for Individuals With Mental Illness

University of California, Los Angeles

NCT01324973

COMPLETED Phase 4 60 participants

The Effect of N-Acetyl Cysteine on Cortical Erosion in Early Stage Schizophrenia

Indiana University

NCT01339858

COMPLETED Phase 2 60 participants

High Dose of Quetiapine in Treating Subjects With Treatment Refractory Schizophrenia or Schizoaffective Disorder

Manhattan Psychiatric Center

NCT00297947

COMPLETED Phase 1 60 participants

A Clinical Study to Learn if SEP-363856 Has Physical Dependence in Adults With Schizophrenia

Otsuka Pharmaceutical Development & Commercialization

NCT05848700

COMPLETED Phase 4 60 participants

Effects of Pravastatin on Cholesterol, Inflammation and Cognition in Schizophrenia

Massachusetts General Hospital

NCT01082588

COMPLETED Phase 3 59 participants

Aripiprazole Oral Acceptability Trial

Otsuka Pharmaceutical Development & Commercialization

NCT00101569

COMPLETED Phase 1 59 participants

The Effects AZD8529 on Cognition and Negative Symptoms in Schizophrenics

AstraZeneca

NCT00986531

COMPLETED NA 56 participants

In-person vs. Remote Wellness Support

The University of Texas Health Science Center at San Antonio

NCT04526067

COMPLETED NA 55 participants

Life Goals Behavioral Change to Improve Outcomes for Veterans With Serious Mental Illness

VA Office of Research and Development

NCT01244854

COMPLETED NA 53 participants

Benefits of Physical Exercise in Schizophrenia

VA Office of Research and Development

NCT02716584

COMPLETED NA 53 participants

A Study to Evaluate the Overall Effects of Treatment With Abbreviated CT-156 in People With Schizophrenia

Click Therapeutics

NCT06136936

COMPLETED Phase 2 52 participants

Study to Demonstrate Cognitive Enhancing Effects of BF2.649

University of Texas Southwestern Medical Center

NCT00690274

COMPLETED Phase 4 51 participants

Treatment of Cognitive and Negative Symptoms in Schizophrenia With N-acetylcysteine

University of California, Los Angeles

NCT02505477

COMPLETED NA 51 participants

Development of a Mobile System for Self-management of Schizophrenia (SOS)

Dartmouth-Hitchcock Medical Center

NCT01969500

COMPLETED Phase 4 50 participants

Controlled Trial of Brexpiprazole For The Treatment of Co-occurring Schizophrenia and Substance Use Disorder

University of Massachusetts, Worcester

NCT03526354

COMPLETED 50 participants

Do Self-Report and Physician Impressions of Adherence to Oral Antipsychotic Medication Agree With Objective Data?

The University of Texas Health Science Center at San Antonio

NCT00223522

COMPLETED NA 50 participants

Transcranial Magnetic Stimulation (TMS) Treatment for Patients With Persistent Auditory Hallucinations

Yale University

NCT00042159

COMPLETED NA 50 participants

Omega-3 Dietary Supplements in Schizophrenia

Delbert Robinson

NCT01786239

COMPLETED NA 49 participants

Effectiveness of a Mobile Texting Intervention for People With Serious Mental Illness

University of Washington

NCT03062267

COMPLETED NA 48 participants

Exploratory Study of a Digital Therapeutics in People With Schizophrenia

Click Therapeutics

NCT05438160

COMPLETED NA 48 participants

Enhancing Cognitive Training Through Exercise After a First Schizophrenia Episode

University of California, Los Angeles

NCT02267070

COMPLETED Phase 1 48 participants

A Study to Determine Pharmacokinetic Characteristics of LY03010 Versus INVEGA SUSTENNA® in Schizophrenia Patients

Luye Pharma Group

NCT03751488

COMPLETED Phase 2 48 participants

Levetiracetam in Early Psychosis

NYU Langone Health

NCT03129360

COMPLETED Phase 1 47 participants

Safety and Tolerability Study of Lu AF11167 After Repeated Dosing in Patients With Schizophrenia

H. Lundbeck A/S

NCT02202213

COMPLETED NA 47 participants

Using Transcranial Magnetic Stimulation (TMS) to Understand 'Negative' Symptoms of Schizophrenia

Beth Israel Deaconess Medical Center

NCT03648268

COMPLETED Phase 1 47 participants

A Study of Aripiprazole Lauroxil in Subjects With Schizophrenia or Schizoaffective Disorder

Alkermes

NCT02636842

COMPLETED Phase 4 46 participants

Folate Supplementation in Schizophrenia

Massachusetts General Hospital

NCT00249288

COMPLETED Phase 4 46 participants

Comparative Effects of Chronic Treatment With Olanzapine and Risperidone on Glucose and Lipid Metabolism

Nathan Kline Institute for Psychiatric Research

NCT00287820

COMPLETED Phase 1 45 participants

D-serine Augmentation of Neuroplasticity

New York State Psychiatric Institute

NCT03711500

COMPLETED Phase 1 45 participants

Single Ascending Dose Study of RBP-7000

Indivior

NCT02768649

COMPLETED 44 participants

Antipsychotics and Blood Vessel Function

Jess G. Fiedorowicz

NCT00585273

COMPLETED NA 44 participants

Effects of Smoking Cues on Tobacco Craving Responses and the Reinforcing Efficacy of Cigarettes in Smokers With and Without Schizophrenia

University of Maryland, Baltimore

NCT00770237

COMPLETED Phase 1 44 participants

PK, Safety, and Tolerability Study of RBP-7000 of Different Molecular Weight Polymer in Subjects With Schizophrenia

Indivior

NCT02687984

COMPLETED Phase 4 40 participants

Atomoxetine for Treatment of Weight Gain in Olanzapine or Clozapine Patients

University of Maryland, Baltimore

NCT00176436

← Previous Page 5 of 7 Next →

Phase Distribution

PhaseTrial count
Phase 1 47
Phase 2 40
Phase 3 50
Phase 4 40

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Schizophrenia Trial Landscape

318 indexed Schizophrenia studies · 76 recruiting (24%).

Phase mix: 90 late (III/IV) vs 87 early (I/II).

Top sponsor: University of Maryland, Baltimore (14 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Schizophrenia?

PlainTrial tracks 318 US clinical trials for Schizophrenia, of which 76 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Schizophrenia?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.