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2026 data Public-data reference. official source

Emphysema

Open-data reference.

27 US clinical trials · 8 currently recruiting

Active & Recent Trials

RECRUITING 75,000 participants

COPD Patient-Powered Research Network

COPD Foundation

NCT02803242

RECRUITING 3,000 participants

Emphysema Research Registry and Biosample Repository

University of Pittsburgh

NCT00307281

RECRUITING NA 250 participants

Bronchoscopic RElease of Air Trapped in Hyperinflated Emphysematous Lung - Study 3

Apreo Health

NCT06891755

RECRUITING Phase 2 185 participants

Long-term, Open-label Study of SAR447537 (INBRX-101) in Adults With Alpha-1 Antitrypsin Deficiency Emphysema

Sanofi

NCT05897424

RECRUITING 150 participants

STRIVE Post-Market Registry Study

Olympus Corporation of the Americas

NCT04302272

RECRUITING NA 80 participants

Implementation of a Sarcopenia Clinic to Diagnose and Treat Skeletal Muscle Loss Due to COPD

The Cleveland Clinic

NCT07059637

RECRUITING 60 participants

Site and Mechanism(s) of Expiratory Airflow Limitation in COPD, Emphysema and Asthma-COPD Overlap

Gelb, Arthur F., M.D.

NCT03263130

RECRUITING Phase 2 30 participants

Biological Effects of Quercetin in COPD Phase II

Temple University

NCT06003270

ACTIVE NOT RECRUITING 10,718 participants

Examining the Genetic Factors That May Cause Chronic Obstructive Pulmonary Disease (COPD)

Brigham and Women's Hospital

NCT00608764

ACTIVE NOT RECRUITING 2,981 participants

Study of COPD Subgroups and Biomarkers

University of North Carolina, Chapel Hill

NCT01969344

ACTIVE NOT RECRUITING 150 participants

Zephyr Valve Registry (ZEVR)

Pulmonx Corporation

NCT04186546

ACTIVE NOT RECRUITING Phase 2 133 participants

Doxycycline for Emphysema in People Living With HIV (The DEPTH Trial)

Weill Medical College of Cornell University

NCT05382208

ACTIVE NOT RECRUITING Phase 4 17 participants

Functional CT Assessment of Pulmonary Arterial Dysfunction in Smoking Associated Emphysema

Eric A. Hoffman

NCT02682147

COMPLETED Phase 3 741 participants

Determine the Safety and Efficacy of (R,R)-Formoterol in the Treatment of Subjects With COPD

Sumitomo Pharma America

NCT00064402

COMPLETED Phase 3 443 participants

Safety and Efficacy of Arformoterol Tartrate Inhalation Solution in Subjects With Chronic Obstructive Pulmonary Disease

Sumitomo Pharma America

NCT00250679

COMPLETED NA 277 participants

Clinical Trial to Evaluate the Safety and Effectiveness of the IBV® Valve System for the Treatment of Severe Emphysema

Olympus Corporation of the Americas

NCT00475007

COMPLETED 255 participants

Evaluating Genetic Factors That May Contribute to Elastin Function and the Development of Chronic Obstructive Pulmonary Disease

Washington University School of Medicine

NCT00725309

COMPLETED Phase 4 220 participants

Losartan Effects on Emphysema Progression

JHSPH Center for Clinical Trials

NCT02696564

COMPLETED Phase 2 118 participants

Prostaglandin Inhibition for Emphysema

University of Nebraska

NCT02006576

COMPLETED 117 participants

Alpha-1 Carrier Genomics Study

Medical University of South Carolina

NCT02810327

COMPLETED Phase 4 50 participants

Airway Clearance for Prevention of Chronic Obstructive Pulmonary Disease (COPD) Exacerbation

Johns Hopkins University

NCT00181207

COMPLETED Phase 1 44 participants

Evaluation of Regional Ventilation Using 19F MRI of Inert Perfluorinated Gases Mixed With Oxygen

Hal C Charles

NCT01710449

COMPLETED NA 24 participants

Ex-vivo Perfusion and Ventilation of Lungs Recovered From Non-Heart-Beating Donors to Assess Transplant Suitability

University of North Carolina, Chapel Hill

NCT01615484

COMPLETED Phase 1 17 participants

Real-Time Support for Exercise Persistence in COPD

University of Washington

NCT00373932

COMPLETED Phase 2 17 participants

Belimumab Treatment of Emphysema Patients With Anti-GRP78 Autoantibodies

University of Alabama at Birmingham

NCT03244059

COMPLETED NA 6 participants

A Home-based Intervention to Promote Mindful Breathing Awareness Through Pursed-lip Breathing Training for COPD Patients

Mayo Clinic

NCT03814980

COMPLETED NA

Lung Volume Reductions Surgery (LVRS) Study

US Department of Veterans Affairs

NCT00018525

Phase Distribution

PhaseTrial count
Early Phase 1 2
Phase 2 5
Phase 3 2
Phase 4 3

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Emphysema Trial Landscape

ClinicalTrials.gov lists 27 US studies indexed under Emphysema, and 8 of those are currently open to recruitment — roughly 30% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

The phase distribution for Emphysema shows 5 late-stage studies (Phase 3 and Phase 4 combined) alongside 7 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

Top sponsor activity for Emphysema is led by Olympus Corporation of the Americas with 2 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 27 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Emphysema?

PlainTrial tracks 27 US clinical trials for Emphysema, of which 8 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Emphysema?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2024 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

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