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Emphysema clinical trials
8 of 27 indexed Emphysema trials are currently recruiting.
27 US clinical trials · 8 currently recruiting
Emphysema is the subject of 27 registered US clinical trials on ClinicalTrials.gov, 8 of them currently open to new participants. 5 are in Phase 3-4 (later-stage) and 7 in Phase 1-2 (earlier-stage). The most active sponsor is Olympus Corporation of the Americas, running 2 of these trials.
The research picture
Emphysema has 27 registered US clinical trials, 8 of them open to new participants right now, about 30% of the total.
- 8
- recruiting participants now
- 30%
- of trials open to enrollment
- 5
- in Phase 3–4 (later-stage)
- 2
- top sponsor: Olympus Corporation of the Americas
Active & Recent Trials
27 total, page 1 of 1
COPD Patient-Powered Research Network
COPD Foundation
NCT02803242
Emphysema Research Registry and Biosample Repository
University of Pittsburgh
NCT00307281
Bronchoscopic RElease of Air Trapped in Hyperinflated Emphysematous Lung - Study 3
Apreo Health
NCT06891755
Long-term, Open-label Study of SAR447537 (INBRX-101) in Adults With Alpha-1 Antitrypsin Deficiency Emphysema
Sanofi
NCT05897424
STRIVE Post-Market Registry Study
Olympus Corporation of the Americas
NCT04302272
Implementation of a Sarcopenia Clinic to Diagnose and Treat Skeletal Muscle Loss Due to COPD
The Cleveland Clinic
NCT07059637
Site and Mechanism(s) of Expiratory Airflow Limitation in COPD, Emphysema and Asthma-COPD Overlap
Gelb, Arthur F., M.D.
NCT03263130
Biological Effects of Quercetin in COPD Phase II
Temple University
NCT06003270
Examining the Genetic Factors That May Cause Chronic Obstructive Pulmonary Disease (COPD)
Brigham and Women's Hospital
NCT00608764
Study of COPD Subgroups and Biomarkers
University of North Carolina, Chapel Hill
NCT01969344
Zephyr Valve Registry (ZEVR)
Pulmonx Corporation
NCT04186546
Doxycycline for Emphysema in People Living With HIV (The DEPTH Trial)
Weill Medical College of Cornell University
NCT05382208
Functional CT Assessment of Pulmonary Arterial Dysfunction in Smoking Associated Emphysema
Eric A. Hoffman
NCT02682147
Determine the Safety and Efficacy of (R,R)-Formoterol in the Treatment of Subjects With COPD
Sumitomo Pharma America
NCT00064402
Safety and Efficacy of Arformoterol Tartrate Inhalation Solution in Subjects With Chronic Obstructive Pulmonary Disease
Sumitomo Pharma America
NCT00250679
Clinical Trial to Evaluate the Safety and Effectiveness of the IBV® Valve System for the Treatment of Severe Emphysema
Olympus Corporation of the Americas
NCT00475007
Evaluating Genetic Factors That May Contribute to Elastin Function and the Development of Chronic Obstructive Pulmonary Disease
Washington University School of Medicine
NCT00725309
Losartan Effects on Emphysema Progression
JHSPH Center for Clinical Trials
NCT02696564
Prostaglandin Inhibition for Emphysema
University of Nebraska
NCT02006576
Alpha-1 Carrier Genomics Study
Medical University of South Carolina
NCT02810327
Airway Clearance for Prevention of Chronic Obstructive Pulmonary Disease (COPD) Exacerbation
Johns Hopkins University
NCT00181207
Evaluation of Regional Ventilation Using 19F MRI of Inert Perfluorinated Gases Mixed With Oxygen
Hal C Charles
NCT01710449
Ex-vivo Perfusion and Ventilation of Lungs Recovered From Non-Heart-Beating Donors to Assess Transplant Suitability
University of North Carolina, Chapel Hill
NCT01615484
Real-Time Support for Exercise Persistence in COPD
University of Washington
NCT00373932
Belimumab Treatment of Emphysema Patients With Anti-GRP78 Autoantibodies
University of Alabama at Birmingham
NCT03244059
A Home-based Intervention to Promote Mindful Breathing Awareness Through Pursed-lip Breathing Training for COPD Patients
Mayo Clinic
NCT03814980
Lung Volume Reductions Surgery (LVRS) Study
US Department of Veterans Affairs
NCT00018525
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 2 |
| Phase 2 | 5 |
| Phase 3 | 2 |
| Phase 4 | 3 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Emphysema Trial Landscape
27 indexed Emphysema studies · 8 recruiting (30%).
Phase mix: 5 late (III/IV) vs 7 early (I/II).
Top sponsor: Olympus Corporation of the Americas (2 trials), 9 others listed. 27 shown below, recruiting first.
How to read this condition's trial landscape
That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Emphysema?
PlainTrial tracks 27 US clinical trials for Emphysema, of which 8 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Emphysema?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.