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ClinicalTrials.gov 31 recruiting now full pipeline #125 of 28,707 conditions

Schizoaffective Disorder: full-pipeline trial registry

31 of 105 indexed Schizoaffective Disorder trials are currently recruiting.

Corpus placement: #125 of 28,707 conditions by registered trial count.

105 US clinical trials · 31 currently recruiting · #125 of 28,707 conditions by registered trial count

Schizoaffective Disorder: 105 US clinical trials tracked, 31 recruiting.

Schizoaffective Disorder is the subject of 105 registered US clinical trials on ClinicalTrials.gov, 31 of them currently open to new participants. 20 are in Phase 3-4 (later-stage) and 21 in Phase 1-2 (earlier-stage). The most active sponsor is University of Maryland, Baltimore, running 8 of these trials.

Enrollment posture brief

Registry condition schizoaffective-disorder

OPEN 31 | RECR 30% | LATE 20 | EARLY 21 | RANK #125 | SPON 8

Nearest open-share peer: Emphysema (30% recruiting · 27 trials)

Autism46.7%Cognitive Impairment43.4%Migraine38.1%Hematopoietic and Lymphoid C33.3%Schizoaffective Disorder (th…30%
Open-enrollment share among volume-matched conditions near Schizoaffective Disorder

Schizoaffective Disorder lists 31 open slots (30% of 105 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →

Key findings

What ClinicalTrials.gov does not surface for Schizoaffective Disorder on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.

  1. Schizoaffective Disorder is recruiting below its size-band peers.

    31 of 105 indexed trials (29.5%) are open to enrollment, against a 37.1% average across 139 conditions with 100+ trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.

  2. Sponsorship of Schizoaffective Disorder trials is spread across many organizations.

    University of Maryland, Baltimore accounts for 8 of 105 trials (7.6%). 56 distinct sponsors appear on at least one study for this condition label.

  3. Most Schizoaffective Disorder trials plan to enrol fewer than 100 people.

    Median target enrolment is 67 among the 104 trials that report a genuine target (sentinel values excluded). 66 of those (63.5%) plan for fewer than 100 participants.

  4. Schizoaffective Disorder research is mostly interventional.

    99 interventional and 6 observational studies make up this index (94.3% interventional). Study type is sponsor-reported on ClinicalTrials.gov.

Phase 110Phase 211Phase 34Phase 416

Open and recent trials

105 total, page 2 of 3

COMPLETED NA 168 participants

Virtual Reality Job Interview Training in Severe Mental Illness

University of Michigan

NCT03049813

COMPLETED Phase 2 150 participants

Work Activity Augmented by Cognitive Rehabilitation for Schizophrenia

VA Office of Research and Development

NCT00430560

COMPLETED NA 149 participants

A New Paradigm for Illness Monitoring and Relapse Prevention in Schizophrenia

Dartmouth-Hitchcock Medical Center

NCT01952041

COMPLETED NA 122 participants

Personalized and Scalable Cognitive Remediation Approaches

New York State Psychiatric Institute

NCT01945333

COMPLETED NA 122 participants

Cognitive-Behavioral Therapy in Veterans With Schizophrenia

VA Office of Research and Development

NCT00688259

COMPLETED NA 120 participants

Evaluation of A Statewide Program to Prevent Early Mortality and to Promote Fitness in Persons With SMI

Dartmouth-Hitchcock Medical Center

NCT02334280

COMPLETED Phase 1 119 participants

Study Investigating the Effect of Lu AF35700 on Cardiac Repolarization in Men and Women With Schizophrenia and Schizoaffective Disorder

H. Lundbeck A/S

NCT02901587

COMPLETED NA 106 participants

A Study of Strategies to Improve Schizophrenia Treatment

US Department of Veterans Affairs

NCT00156637

COMPLETED Phase 3 104 participants

D-Serine Treatment of Negative Symptoms and Cognitive Deficits in Schizophrenia

Yale University

NCT00237809

COMPLETED Phase 2 97 participants

Nicotinic Receptors and Schizophrenia

University of Colorado, Denver

NCT01400477

COMPLETED NA 87 participants

Mobile Self-Tracking of Mental Health

VA Office of Research and Development

NCT05023252

COMPLETED NA 85 participants

Luteolin for the Treatment of People With Schizophrenia

University of Maryland, Baltimore

NCT05204407

COMPLETED NA 83 participants

Oxytocin and CBSST for People With Schizophrenia

University of Maryland, Baltimore

NCT01752712

COMPLETED Phase 2 76 participants

Cognitive - Behavioral Therapy

US Department of Veterans Affairs

NCT00018629

COMPLETED NA 69 participants

Cognitive Training for Patients With Schizophrenia

University of California, San Diego

NCT01521026

COMPLETED NA 67 participants

Improving Accessibility and Personalization of CR for Schizophrenia

New York State Psychiatric Institute

NCT03576976

COMPLETED Phase 2 66 participants

Study in Stabilized Schizophrenic Patients to Evaluate the Pharmacokinetics of Risperidone and 9-Hydroxy (OH)-Risperidone When Risperidone is Administered From a Polyurethane Implant

Braeburn Pharmaceuticals

NCT02658357

COMPLETED NA 65 participants

Double-Blind Trial of a Probiotic Supplement to Reduce the Symptoms of Schizophrenia

Sheppard Pratt Health System

NCT01242371

COMPLETED Phase 4 64 participants

Determining the Effects of Risperdal Consta in Patients With Psychotic Disorders and Incomplete Adherence

Duke University

NCT00215579

COMPLETED Phase 2 62 participants

Memantine Augmentation of Targeted Cognitive Training in Schizophrenia

University of California, San Diego

NCT04857983

COMPLETED Phase 4 60 participants

The Effect of N-Acetyl Cysteine on Cortical Erosion in Early Stage Schizophrenia

Indiana University

NCT01339858

COMPLETED Phase 2 60 participants

High Dose of Quetiapine in Treating Subjects With Treatment Refractory Schizophrenia or Schizoaffective Disorder

Manhattan Psychiatric Center

NCT00297947

COMPLETED NA 56 participants

In-person vs. Remote Wellness Support

The University of Texas Health Science Center at San Antonio

NCT04526067

COMPLETED NA 51 participants

Development of a Mobile System for Self-management of Schizophrenia (SOS)

Dartmouth-Hitchcock Medical Center

NCT01969500

COMPLETED Phase 4 50 participants

Controlled Trial of Brexpiprazole For The Treatment of Co-occurring Schizophrenia and Substance Use Disorder

University of Massachusetts, Worcester

NCT03526354

COMPLETED NA 50 participants

Omega-3 Dietary Supplements in Schizophrenia

Delbert Robinson

NCT01786239

COMPLETED NA 49 participants

Effectiveness of a Mobile Texting Intervention for People With Serious Mental Illness

University of Washington

NCT03062267

COMPLETED NA 48 participants

Enhancing Cognitive Training Through Exercise After a First Schizophrenia Episode

University of California, Los Angeles

NCT02267070

COMPLETED Phase 1 48 participants

A Study to Determine Pharmacokinetic Characteristics of LY03010 Versus INVEGA SUSTENNA® in Schizophrenia Patients

Luye Pharma Group

NCT03751488

COMPLETED Phase 2 48 participants

Levetiracetam in Early Psychosis

NYU Langone Health

NCT03129360

COMPLETED Phase 1 47 participants

A Study of Aripiprazole Lauroxil in Subjects With Schizophrenia or Schizoaffective Disorder

Alkermes

NCT02636842

COMPLETED NA 47 participants

Using Transcranial Magnetic Stimulation (TMS) to Understand 'Negative' Symptoms of Schizophrenia

Beth Israel Deaconess Medical Center

NCT03648268

COMPLETED Phase 1 45 participants

D-serine Augmentation of Neuroplasticity

New York State Psychiatric Institute

NCT03711500

COMPLETED NA 40 participants

Texting for Relapse Prevention

Center for Innovative Public Health Research

NCT02819349

COMPLETED NA 40 participants

Confirmatory Efficacy Trial of a Gluten-Free Diet in a Subgroup of Persons With Schizophrenia Who Have High Levels of IgG Anti-Gliadin Antibodies (AGA IG)

University of Maryland, Baltimore

NCT03183609

COMPLETED NA 32 participants

A Comparison of Two Cognitive Batteries in People With Schizophrenia

North Suffolk Mental Health Association

NCT00499044

COMPLETED NA 31 participants

Motivation and Skills Support (MASS)

Boston University Charles River Campus

NCT03404219

COMPLETED NA 30 participants

A Concierge Model of CAE Plus LAI in Individuals With Schizophrenia at Risk for Treatment Non-adherence and Homelessness

University Hospitals Cleveland Medical Center

NCT02085447

COMPLETED Phase 4 26 participants

Prebiotic Treatment in People With Schizophrenia - Pilot Study

University of Maryland, Baltimore

NCT03617783

COMPLETED Phase 4 25 participants

Ramelteon as an Adjunct Therapy in Non-Diabetic Patients With Schizophrenia

Massachusetts General Hospital

NCT00595504

COMPLETED NA 25 participants

Financial Incentives to Improve Medication Adherence

Northwell Health

NCT04191876

COMPLETED NA 24 participants

Pilot Trial of Naltrexone for Obesity in Women With Schizophrenia

Yale University

NCT00793780

COMPLETED NA 21 participants

Neuroendocrine and Immune Response to Stress in Schizophrenia

University of Maryland, Baltimore

NCT01975584

COMPLETED NA 20 participants

NST-SPARK: Preliminary Study of an Augmented Reality (AR) App Delivering Recovery-Oriented Cognitive Therapy for Negative Symptoms in Schizophrenia

North Shore Therapeutics

NCT06653829

COMPLETED Phase 4 20 participants

Galantamine for Cognition in People With Schizophrenia

North Suffolk Mental Health Association

NCT00320736

COMPLETED Phase 2 19 participants

Effects of Pentazocine Versus Lorazepam on Manic Symptoms

Mclean Hospital

NCT00431184

COMPLETED NA 19 participants

Brain Stimulation and Cognitive Training - Efficacy

University of Michigan

NCT05111548

COMPLETED Phase 1 18 participants

M1 Schizophrenia PET Study

Yale University

NCT05105542

COMPLETED Phase 2 16 participants

Biomarkers in Schizophrenia

Nathan Kline Institute for Psychiatric Research

NCT00817336

COMPLETED Phase 1 16 participants

An Randomized Open-Label PK Study of LY03004 Compared to Risperdal® Consta® in Stable Patients With Schizophrenia or Schizoaffective Disorder

Luye Pharma Group

NCT02186769

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Phase Distribution

PhaseTrial count
Phase 1 10
Phase 2 11
Phase 3 4
Phase 4 16

Named interventions

Most-linked intervention names on Schizoaffective Disorder records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.

Placebo Drug
14 trials
D-serine Drug
2 trials
Cognitive Remediation Behavioral
2 trials
Cognitive training Behavioral
2 trials
Placebo Other
2 trials
CRT and Social Cognition Behavioral
1 trials
Computerized Cognitive Skill Training Behavioral
1 trials
Enhanced treatment as usual (e-TAU) Behavioral
1 trials

US sites by state

Facility locations filed on Schizoaffective Disorder trials. A trial with sites in several states counts in each.

California 29 trials
New York 19 trials
Maryland 16 trials
Massachusetts 16 trials
Texas 11 trials
Pennsylvania 10 trials
Georgia 10 trials
Illinois 9 trials

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

What to do with this Schizoaffective Disorder page

105 registered trials, 31 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.

Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Schizoaffective Disorder condition card totals 105 registered trials; most-linked intervention Placebo; top US site state California. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.