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NCT01644279 · ClinicalTrials.gov registry record
Skeletal Muscle Apoptosis and Physical Performance; Oxidative RNA/DNA Damage and Repair in Aged Human Muscle
A clinical trial of Sarcopenia, sponsored by University of Florida.
- Completed
- Registry status
- 63
- Enrollment target
- 1
- Study location
NCT01644279: Completed study of Sarcopenia, sponsored by University of Florida.
NCT01644279 is a study of Sarcopenia that has completed, run by University of Florida. The registered enrollment target is 63 participants, below the 79-participant average among 41 other Sarcopenia trials with a reported enrollment target (20% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT01644279, a study of Sarcopenia, has completed, sponsored by University of Florida.
- COMPLETED
- Registry status
- 63 participants
- Enrollment target
- 1
- Study location
Study Summary
The age-related loss of muscle mass and strength, also termed sarcopenia, is a commonly recognized consequence of aging and has been associated with frailty, functional loss, hospitalization, and increased mortality among older people. Sarcopenia and its consequences have a considerable economic impact, since it has been estimated that the healthcare cost attributable to sarcopenia in the US in 2000 was $ 18.5 billions. Preclinical animal models strongly suggest that apoptosis, a programmed cell death, might play a prominent role in the age-related muscle wasting. In specific aim one, the investigators will assess the extent of muscle apoptosis in muscle biopsies obtained from the vastus lateralis muscle of young control subjects (ages 20-35) and high-performance and low-performance older subjects (age range 70-99 years). In specific aim 2, the investigators will investigate the role of Poly (ADP-ribose) polymerase 1 (PARP-1) and apoptosis-inducing factor (AIF) in the induction of skeletal muscle apoptosis. In specific aim 3, the investigators propose to investigate the contribution of the muscle energy deficit, due to the age-related mitochondrial dysfunction, in the development of muscle wasting. Finally, in specific aim 4, the investigators propose to reassess after four years physical performance, muscle mass and the extent of muscle apoptosis, in the high-performing participants, in order to correlate eventual decline in physical function, muscle mass and functional status, with changes in muscle apoptosis and in biochemical parameters in this very old population. Physical performance will be established according to the summary performance score obtained in the Short Form Physical Performance Battery (SPPB). In addition to the SPPB the investigators will also employ hand grip strength and knee extensor strength tests and the investigators will quantify muscle contractile area using 3D magnetic resonance imaging. Disability will be assessed using a self-report
Primary Outcome
The SPPB is composed by three subtasks: usual gait speed, standing balance and chair stand tests.
Conditions Studied
Study Locations (1)
Florida
- University of Florida - Gainesville
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 63 participants |
| Start Date | 2006-03 |
| Est. Completion | 2016-07 |
What the finished NCT01644279 record still lists
NCT01644279 is an observational study that tracks outcomes without assigning an intervention. The registry caps enrollment at 63 participants, a relatively small participant target, below the 79-participant average among 41 other Sarcopenia trials with a reported enrollment target (20% lower).
The record links to 1 condition, with Sarcopenia appearing as the primary indexed condition, and to 0 interventions.
NCT01644279 reports a single indexed study location in Florida.
Frequently Asked Questions
What is clinical trial NCT01644279 about?
NCT01644279 is a clinical study titled "Skeletal Muscle Apoptosis and Physical Performance; Oxidative RNA/DNA Damage and Repair in Aged Human Muscle". The age-related loss of muscle mass and strength, also termed sarcopenia, is a commonly recognized consequence of aging and has been associated with frailty, functional loss, hospitalization, and increased mortality among older people. Sarcopenia and its consequences have a considerable economic imp...
What is the current status of trial NCT01644279?
This trial is currently completed. The enrollment target is 63 participants. The study started on 2006-03. Estimated completion is 2016-07.
What conditions does trial NCT01644279 study?
This clinical trial studies the following conditions: Sarcopenia.
Who is sponsoring clinical trial NCT01644279?
This trial is sponsored by University of Florida, which has 1,106 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT01644279 being conducted?
This trial has 1 study location across Florida. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Where NCT01644279's enrollment target sits among peer trials
63 20th of 41 higher than 22 of 41 other Sarcopenia trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Sarcopenia trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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