Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT04691986 · ClinicalTrials.gov registry record · NA
Impacts of Nicotinamide Riboside on Functional Capacity and Muscle Physiology in Older Veterans
A NA study of Sarcopenia and Nicotinamide Adenine Dinucleotide Concentration, sponsored by VA Office of Research and Development.
- Recruiting
- Registry status
- NA
- Development phase
- 144
- Enrollment target
- 1
- Study location
NCT04691986: Recruiting NA study of Sarcopenia and Nicotinamide Adenine Dinucleotide Concentration, sponsored by VA Office of Research and Development.
NCT04691986 is a NA study of Sarcopenia and Nicotinamide Adenine Dinucleotide Concentration that is actively recruiting participants, run by VA Office of Research and Development. The registered enrollment target is 144 participants, above the 77-participant average among 41 other Sarcopenia trials with a reported enrollment target (87% higher). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04691986, a NA study of Sarcopenia and Nicotinamide Adenine Dinucleotide Concentration, is actively recruiting participants, sponsored by VA Office of Research and Development.
- RECRUITING
- Registry status
- NA
- Development phase
- 144 participants
- Enrollment target
- 1
- Study location
Study Summary
Frailty is an age-associated clinical condition of poor physiological reserve that increases risks for falls, hospitalization and mortality. Nicotinamide adenine dinucleotide (NAD) is a critical co-factor needed for many cellular processes. The natural levels of NAD decline aging and this has been linked to physical performance decline in animals. Human trials have demonstrated that nicotinamide riboside (NR), a form of vitamin B3, is safe and effectively increases NAD+ levels. In animal studies, NR improves treadmill performance and muscle quality. Here the investigators propose a double-blind randomized control trial to assess the benefits of NR supplementation on human muscle function and physiology. The investigators anticipate the research findings will support the use of this nutritional supplement to improve the health of Veterans during aging.
Primary Outcome
Participants are asked to exercise on an recumbent exercise bike as the resistance increases over time. During the exercise, participants are asked to breath through a mask that is connected to a oxygen and carbon dioxide measuring device. Participant will be asked to continue until they report exhaustion, reach 85% of heart rate maximum, or if there are medical concerns. The assessment last for approximately 15 minutes and provides data the pertain to an individuals lung capacity, breathing rat
Conditions Studied
Interventions
- OTHER Placebo
- DIETARY_SUPPLEMENT Nicotinamide Riboside
Study Locations (1)
Missouri
- Kansas City VA Medical Center, Kansas City, MO - Kansas City
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 144 participants |
| Start Date | 2023-09-01 |
| Est. Completion | 2026-06-30 |
| Phase | NA |
What NCT04691986 shows while recruiting
NCT04691986 is an interventional study that assigns participants to a tested intervention. The registered 144 participants enrollment target is mid-sized for trials with a published cap, above the 77-participant average among 41 other Sarcopenia trials with a reported enrollment target (87% higher).
The record links to 3 conditions, with Sarcopenia appearing as the primary indexed condition, and to 2 interventions - of which Placebo is the first listed.
NCT04691986 reports a single indexed study location in Missouri.
Frequently Asked Questions
What is clinical trial NCT04691986 about?
NCT04691986 is a clinical study titled "Impacts of Nicotinamide Riboside on Functional Capacity and Muscle Physiology in Older Veterans". Frailty is an age-associated clinical condition of poor physiological reserve that increases risks for falls, hospitalization and mortality. Nicotinamide adenine dinucleotide (NAD) is a critical co-factor needed for many cellular processes. The natural levels of NAD decline aging and this has been l...
What is the current status of trial NCT04691986?
This trial is currently recruiting. It is a NA study. The enrollment target is 144 participants. The study started on 2023-09-01. Estimated completion is 2026-06-30.
What conditions does trial NCT04691986 study?
This clinical trial studies the following conditions: Sarcopenia, Nicotinamide Adenine Dinucleotide Concentration, Muscle Quality and NAD+ Content.
What interventions are being tested in trial NCT04691986?
The interventions under investigation include: Placebo (OTHER), Nicotinamide Riboside (DIETARY_SUPPLEMENT).
Who is sponsoring clinical trial NCT04691986?
This trial is sponsored by VA Office of Research and Development, which has 1,668 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT04691986 being conducted?
This trial has 1 study location across Missouri. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Sarcopenia
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT04691986's enrollment target sits among peer trials
144 7th of 41 higher than 35 of 41 other Sarcopenia trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Sarcopenia trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
-
Exercise and Nutritional Prehabilitation for Head and Neck Cancer Patients
RECRUITING · NA
-
Effects of Whole-body Electrical Muscle Stimulation Exercise on Spinal Motoneuronal Activation in Older Adults
RECRUITING · NA
-
Strength Training and Resveratrol
RECRUITING · NA
-
Project Gnosis: the Neurophysical and Psychosocial Health Outcomes of Tai Chi for Older Adults with Cognitive Concerns or Mild Cognitive Impairment
RECRUITING · NA
-
Multidimensional Predictive Modeling to Understand Mechanisms of Exercise Response Heterogeneity in Older Adults (M3AX)
RECRUITING · NA
-
C-Protein in Fatigue and Aging
RECRUITING · NA
Nationwide trials with similar profiles
Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.
Similar enrollment target
- NCT01861106 · 144 participants · Phase 2
Allogeneic Hematopoietic Stem Cell Transplant for GATA2 Mutations
- NCT03482245 · 144 participants · NA
The Role of Circadian Clock Proteins in Innate and Adaptive Immunity
- NCT03504683 · 144 participants · NA
MEAL TIMING Study: Effect of Time-Restricted Feeding on 24-hour Glycemic Control, Blood Pressure, and Cardiovascular Disease Risk Factors in Adults With Prediabetes
- NCT03905603 · 144 participants · Early Phase 1
Relative Contributions of Predictors of Hyperandrogenism in Older vs. Young Women With PCOS
Similar registry start date
- NCT05962346 · started 2026-12 · NA
Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia
- NCT07125183 · started 2026-12 · Phase 2
Study on Efficacy and Tolerability of Weekly Doxorubicin in Elderly Patients With Advanced or Metastatic Leiomyosarcoma
- NCT07292298 · started 2026-11 · Phase 2
Phase 2 Single-Arm Rectal Cancer Brachytherapy for Patients With Low-Lying Residual Adenocarcinoma After Total Neoadjuvant Therapy to Improve Organ Preservation Rates
- NCT04263285 · started 2026-10 · NA
Treatment of Depression Post-SCI