Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.

RECRUITING Phase 4

A Study to Investigate the Effectiveness of Tirzepatide (LY3298176) Following Initiation of Ixekizumab (LY2439821) in Participants With Moderate-to-Severe Plaque PsO and Obesity or Overweight in Clinical Practice (TOGETHER AMPLIFY-PsO)

NCT06857942 · View on ClinicalTrials.gov ↗

Study Summary

The main purpose of this study is to assess the effectiveness of adding tirzepatide to ixekizumab therapy in standard clinical practice in participants with moderate-to-severe plaque PsO and obesity or overweight with at least 1 weight-related comorbidity. The study will last up to 12 months.

Interventions

  • DRUG Tirzepatide

Study Locations (20)

Florida

  • Alliance for Multispecialty Research, LLC — Fort Myers
  • NeoClinical Research — Hialeah
  • Skin Care Research — Hollywood
  • Encore Medical Research — Hollywood
  • Palm Harbor Dermatology PA d/b/a TrueBlue Clinical Research — Tampa
  • TruDerm & TruSpa — Wellington

California

  • First OC Dermatology Research Inc — Fountain Valley
  • Center For Dermatology Clinical Research, Inc. — Fremont
  • Metropolis Dermatology — Los Angeles
  • Northridge Clinical Trials — Northridge

Michigan

  • David Fivenson, MD, PLC — Ann Arbor
  • Great Lakes Research Group, Inc. — Bay City
  • The Derm Institute of West Michigan — Caledonia

Indiana

  • Dawes Fretzin Clinical Research Group, LLC — Indianapolis
  • The Indiana Clinical Trials Center, PC — Plainfield

Arizona

  • Medical Dermatology Specialists — Phoenix

Georgia

  • Southeast Research Specialists — Douglasville

Kentucky

  • Equity Medical - Bowling Green — Bowling Green

Maryland

  • Dermatology and Skin Cancer Specialists, LLC — Rockville

Trial Details

FieldValue
Enrollment Target 200 participants
Start Date 2025-03-19
Est. Completion 2028-05
Phase Phase 4

Sponsor

Eli Lilly and Company

704 total trials

Interested in This Trial?

Always speak with your doctor before enrolling in a clinical trial.

Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT06857942

The ClinicalTrials.gov registry entry for NCT06857942 describes a study currently listed as recruiting. It is categorized as Phase 4, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 200 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Eli Lilly and Company, which has 704 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 2 conditions, with Psoriasis appearing as the primary indexed condition, and to 1 intervention — of which Tirzepatide is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT06857942 reports 20 study locations spanning 9 distinct geographic areas — top geographies include Florida, California, Michigan. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT06857942 about?

NCT06857942 is a clinical study titled "A Study to Investigate the Effectiveness of Tirzepatide (LY3298176) Following Initiation of Ixekizumab (LY2439821) in Participants With Moderate-to-Severe Plaque PsO and Obesity or Overweight in Clinical Practice (TOGETHER AMPLIFY-PsO)". The main purpose of this study is to assess the effectiveness of adding tirzepatide to ixekizumab therapy in standard clinical practice in participants with moderate-to-severe plaque PsO and obesity or overweight with at least 1 weight-related comorbidity. The study will last up to 12 months.

What is the current status of trial NCT06857942?

This trial is currently recruiting. It is a Phase 4 study. The enrollment target is 200 participants. The study started on 2025-03-19. Estimated completion is 2028-05.

What conditions does trial NCT06857942 study?

This clinical trial studies the following conditions: Psoriasis, Overweight or Obesity. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT06857942?

The interventions under investigation include: Tirzepatide (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT06857942?

This trial is sponsored by Eli Lilly and Company, which has 704 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT06857942 being conducted?

This trial has 20 study locations across Arizona, California, Florida, Georgia, Indiana. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial