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ACTIVE NOT RECRUITING Phase 3

Ixekizumab Concomitantly Administered With Tirzepatide in Adults With Moderate-to-Severe Plaque Psoriasis and Obesity or Overweight

NCT06588283 · View on ClinicalTrials.gov ↗

Study Summary

The main purpose of this study is to demonstrate that when participants with moderate to severe plaque psoriasis and obesity or overweight in the presence of at least 1 weight-related comorbid condition receive ixekizumab and tirzepatide concomitantly administered, participants see improvement in their psoriasis and achieve weight reduction compared to when receiving ixekizumab. Participation in this study includes up to 12 visits and could last up to 61 weeks including screening, open label treatment period, and post-treatment follow-up period.

Conditions Studied

Interventions

  • DRUG Tirzepatide
  • DRUG Ixekizumab

Study Locations (20)

California

  • California Dermatology & Clinical Research Institute — Encinitas
  • First OC Dermatology Research Inc — Fountain Valley
  • Avance Clinical Trials — Laguna Niguel
  • Metropolis Dermatology — Los Angeles
  • Dermatology Research Associates — Los Angeles
  • Northridge Clinical Trials — Northridge
  • Cura Clinical Research - Oxnard — Oxnard
  • Integrative Skin Science and Research - Location 2 — Sacramento
  • Therapeutics Clinical Research — San Diego

Florida

  • Life Clinical Trials — Coral Springs
  • Alliance for Multispecialty Research, LLC — Fort Myers
  • NeoClinical Research — Hialeah
  • Skin Care Research — Hollywood
  • Encore Medical Research — Hollywood
  • Solutions Through Advanced Research — Jacksonville

Arizona

  • Medical Dermatology Specialists — Phoenix
  • Scottsdale Clinical Trials — Scottsdale
  • Yuma Clinical Trials — Yuma

Alabama

  • Total Skin & Beauty Dermatology Center, PC DBA Total Dermatology — Birmingham

Arkansas

  • Johnson Dermatology — Fort Smith

Trial Details

FieldValue
Enrollment Target 250 participants
Start Date 2024-09-30
Est. Completion 2026-05
Phase Phase 3

Sponsor

Eli Lilly and Company

704 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT06588283

The ClinicalTrials.gov registry entry for NCT06588283 describes a study currently listed as active not recruiting. It is categorized as Phase 3, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 250 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Eli Lilly and Company, which has 704 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 2 conditions, with Obesity appearing as the primary indexed condition, and to 2 interventions — of which Tirzepatide is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT06588283 reports 20 study locations spanning 5 distinct geographic areas — top geographies include California, Florida, Arizona. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT06588283 about?

NCT06588283 is a clinical study titled "Ixekizumab Concomitantly Administered With Tirzepatide in Adults With Moderate-to-Severe Plaque Psoriasis and Obesity or Overweight". The main purpose of this study is to demonstrate that when participants with moderate to severe plaque psoriasis and obesity or overweight in the presence of at least 1 weight-related comorbid condition receive ixekizumab and tirzepatide concomitantly administered, participants see improvement in th...

What is the current status of trial NCT06588283?

This trial is currently active not recruiting. It is a Phase 3 study. The enrollment target is 250 participants. The study started on 2024-09-30. Estimated completion is 2026-05.

What conditions does trial NCT06588283 study?

This clinical trial studies the following conditions: Obesity, Psoriasis. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT06588283?

The interventions under investigation include: Tirzepatide (DRUG), Ixekizumab (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT06588283?

This trial is sponsored by Eli Lilly and Company, which has 704 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT06588283 being conducted?

This trial has 20 study locations across Alabama, Arizona, Arkansas, California, Florida. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial