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COMPLETED Phase 3

A Study to Investigate Interchangeability of ABP 654 for the Treatment of Participants With Moderate to Severe Plaque Psoriasis

NCT04761627 · View on ClinicalTrials.gov ↗

Study Summary

The purpose of the study is to evaluate pharmacokinetic similarity, efficacy, safety and immunogenicity of multiple switches between ustekinumab and ABP 654 compared with continued use of ustekinumab in participants with moderate to severe plaque psoriasis.

Conditions Studied

Interventions

  • DRUG Ustekinumab
  • DRUG ABP 654

Study Locations (20)

Florida

  • Encore Research Group-Jacksonville Center for Clinical Resea — Jacksonville
  • Altus Research, Inc. — Lake Worth
  • International Dermatology Research, Inc. — Miami
  • Leavitt Medical Associates of Florida d/b/a Ameriderm Research — Ormond Beach
  • Riverchase Dermatology and Cosmetic Surgery — Pembroke Pines
  • Olympian Clinical Research — Tampa

California

  • Zenith Research Inc. — Beverly Hills
  • Center for Dermatology Clinical Research, Inc. — Fremont
  • Quest Dermatology Research — Northridge
  • Southern California Dermatology, Inc — Santa Ana

Georgia

  • Hamilton Research, LLC — Alpharetta
  • Advanced Medical Research PC — Sandy Springs

Arkansas

  • Burke Pharmaceutical Research — Hot Springs

Illinois

  • Dundee Dermatology — West Dundee

Indiana

  • DS Research — Clarksville

Iowa

  • Integrated Clinical Trial Services Inc. — West Des Moines

Kansas

  • Kansas Medical Clinic, PA — Topeka

Trial Details

FieldValue
Enrollment Target 494 participants
Start Date 2021-03-24
Est. Completion 2023-02-28
Phase Phase 3

Sponsor

Amgen

266 total trials

Interested in This Trial?

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT04761627

The ClinicalTrials.gov registry entry for NCT04761627 describes a study currently listed as completed. It is categorized as Phase 3, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 494 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Amgen, which has 266 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Psoriasis appearing as the primary indexed condition, and to 2 interventions — of which Ustekinumab is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT04761627 reports 20 study locations spanning 11 distinct geographic areas — top geographies include Florida, California, Georgia. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT04761627 about?

NCT04761627 is a clinical study titled "A Study to Investigate Interchangeability of ABP 654 for the Treatment of Participants With Moderate to Severe Plaque Psoriasis". The purpose of the study is to evaluate pharmacokinetic similarity, efficacy, safety and immunogenicity of multiple switches between ustekinumab and ABP 654 compared with continued use of ustekinumab in participants with moderate to severe plaque psoriasis.

What is the current status of trial NCT04761627?

This trial is currently completed. It is a Phase 3 study. The enrollment target is 494 participants. The study started on 2021-03-24. Estimated completion is 2023-02-28.

What conditions does trial NCT04761627 study?

This clinical trial studies the following conditions: Psoriasis. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT04761627?

The interventions under investigation include: Ustekinumab (DRUG), ABP 654 (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT04761627?

This trial is sponsored by Amgen, which has 266 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT04761627 being conducted?

This trial has 20 study locations across Arkansas, California, Florida, Georgia, Illinois. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial