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ACTIVE NOT RECRUITING Phase 3

A Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of Subcutaneously Administered Guselkumab for the Treatment of Chronic Plaque Psoriasis in Pediatric Participants

NCT03451851 · View on ClinicalTrials.gov ↗

Study Summary

The purpose of this study is to evaluate the efficacy and safety of guselkumab in pediatric participants aged greater than or equal to 6 through less than 18 years with chronic plaque psoriasis.

Conditions Studied

Interventions

  • DRUG Guselkumab
  • DRUG Etanercept
  • DRUG Placebo for guselkumab

Study Locations (20)

Other

  • Eastern Health Research — Box Hill
  • Royal North Shore Hospital — St Leonards
  • Veracity Clinical Research — Woolloongabba
  • Cliniques Universitaires Saint Luc — Brussels
  • Universitair Ziekenhuis Gent — Ghent
  • Centre Hospitalier Universitaire de Liege Domaine Universitaire du Sart Tilman — Liège
  • Universitatsklinikum Bonn — Bonn

California

  • Stanford University — Palo Alto
  • University of California, San Diego — San Diego

Illinois

  • Northwestern University Feinberg School of Medicine Ann & Robert H Lurie Children's Hospital — Chicago
  • Arlington Dermatology — Rolling Meadows

Texas

  • Arlington Center for Dermatology — Arlington
  • Dell Children's Medical Center of Central Texas — Austin

Alberta

  • Kirk Barber Reseach Inc. — Calgary
  • Dermatology Research Institute Inc — Calgary

Georgia

  • Dermatologic Surgery Specialists — Macon

New Jersey

  • Windsor Dermatology — East Windsor

New York

  • Mt. Sinai School of Medicine — New York

Trial Details

FieldValue
Enrollment Target 120 participants
Start Date 2018-07-11
Est. Completion 2026-12-18
Phase Phase 3

Sponsor

Janssen Research & Development

442 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT03451851

The ClinicalTrials.gov registry entry for NCT03451851 describes a study currently listed as active not recruiting. It is categorized as Phase 3, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 120 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Janssen Research & Development, which has 442 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Psoriasis appearing as the primary indexed condition, and to 3 interventions — of which Guselkumab is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT03451851 reports 20 study locations spanning 10 distinct geographic areas — top geographies include Other, California, Illinois. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT03451851 about?

NCT03451851 is a clinical study titled "A Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of Subcutaneously Administered Guselkumab for the Treatment of Chronic Plaque Psoriasis in Pediatric Participants". The purpose of this study is to evaluate the efficacy and safety of guselkumab in pediatric participants aged greater than or equal to 6 through less than 18 years with chronic plaque psoriasis.

What is the current status of trial NCT03451851?

This trial is currently active not recruiting. It is a Phase 3 study. The enrollment target is 120 participants. The study started on 2018-07-11. Estimated completion is 2026-12-18.

What conditions does trial NCT03451851 study?

This clinical trial studies the following conditions: Psoriasis. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT03451851?

The interventions under investigation include: Guselkumab (DRUG), Etanercept (DRUG), Placebo for guselkumab (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT03451851?

This trial is sponsored by Janssen Research & Development, which has 442 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT03451851 being conducted?

This trial has 20 study locations across California, Georgia, Illinois, New Jersey, New York. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial