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ClinicalTrials.gov 40 recruiting now official registry

Parkinson's Disease clinical trials

40 of 159 indexed Parkinson's Disease trials are currently recruiting.

159 US clinical trials · 40 currently recruiting

Parkinson's Disease is the subject of 159 registered US clinical trials on ClinicalTrials.gov, 40 of them currently open to new participants. 21 are in Phase 3-4 (later-stage) and 55 in Phase 1-2 (earlier-stage). The most active sponsor is VA Office of Research and Development, running 16 of these trials.

The research picture

Parkinson's Disease has 159 registered US clinical trials, 40 of them open to new participants right now, about 25% of the total.

40
recruiting participants now
25%
of trials open to enrollment
21
in Phase 3–4 (later-stage)
16
top sponsor: VA Office of Research and Development
Phase 124Phase 231Phase 311Phase 410

Active & Recent Trials

159 total, page 3 of 4

COMPLETED Phase 1 50 participants

Evaluation of Safety and Tolerability of ENT-01 for the Treatment of Parkinson's Disease Related Constipation

Enterin

NCT03047629

COMPLETED Phase 4 50 participants

Aripiprazole in Patients With Psychosis Associated With Parkinson's Disease

Otsuka Pharmaceutical Development & Commercialization

NCT00095810

COMPLETED Phase 2 50 participants

Effects of Monoamine Reuptake Inhibitor NS2330 in Parkinson's Disease

National Institute of Neurological Disorders and Stroke (NINDS)

NCT00006077

COMPLETED Phase 4 50 participants

The Effect of Rasagiline on Cognition in Parkinson's Disease

Brown University

NCT01382342

COMPLETED Phase 4 48 participants

Selegiline to Zelapar Switch Study in Parkinson Disease Patients

Baylor College of Medicine

NCT00640159

COMPLETED NA 48 participants

Non-invasive Neurostimulation in Parkinson's Disease

Spaulding Rehabilitation Hospital

NCT01615718

COMPLETED NA 47 participants

GPR109A and Parkinson's Disease: Role of Niacin in Outcome Measures

VA Office of Research and Development

NCT03462680

COMPLETED NA 45 participants

The Effects of Dual Task Training in Individuals With Parkinson's Disease

The Cleveland Clinic

NCT02538029

COMPLETED Phase 2 44 participants

Masked Faces in Parkinson Disease: Mechanism and Treatment

University of Florida

NCT00350402

COMPLETED NA 40 participants

Telephone-linked Home-based Exercise Training in PD

VA Office of Research and Development

NCT02898740

COMPLETED 36 participants

Psychiatric and Cognitive Manifestations of Parkinson's Disease

NYU Langone Health

NCT00360633

COMPLETED Phase 1 36 participants

A Study of the Safety and Tolerability of a Single Dose Administration of CVT-301 (Levodopa Inhalation Powder)

Acorda Therapeutics

NCT02807675

COMPLETED Phase 4 34 participants

A Double Blind Placebo Controlled Trial Evaluating Rasagiline Effects on Cognition in Parkinson's Disease Patients With Mild Cognitive Impairment Receiving Dopaminergic Therapy

Georgetown University

NCT01497652

COMPLETED Phase 1 33 participants

Reducing Dyskinesia in Parkinson's Disease With Omega-3 Fatty Acids

VA Office of Research and Development

NCT01563913

COMPLETED Phase 1 32 participants

Relative Bioavailability and Food Effect Study of CVN424

Cerevance Beta

NCT05635461

COMPLETED NA 32 participants

A Trial of Neurocognitive and Supportive Therapy Interventions for Individuals With Parkinson's Disease

Virginia Commonwealth University

NCT01646333

COMPLETED NA 32 participants

Poised for Parkinson's - an Intervention to Increase Embodied Agency in People With Parkinson's Disease and Their Carers

University of Idaho

NCT04726709

COMPLETED NA 31 participants

Non-contact Boxing Training and Traditional Therapeutic Exercise for Persons With Parkinson's Disease

University of Indianapolis

NCT01014663

COMPLETED Phase 2 31 participants

Florbetapir F 18 PET Imaging of Beta-amyloid in Parkinson's Disease Patients

Avid Radiopharmaceuticals

NCT00857532

COMPLETED 31 participants

Dance Exercise as Novel Complementary Therapy for Parkinson's Disease

Beth Israel Deaconess Medical Center

NCT01163344

COMPLETED Phase 4 30 participants

Rasagiline for the Symptomatic Treatment of Fatigue in Parkinson's Disease

University of Florida

NCT01168596

COMPLETED Phase 1 30 participants

A Trial of 18F-AV-133 and 18F-AV-45 Positron Emission Tomography (PET)

Avid Radiopharmaceuticals

NCT01503944

COMPLETED Phase 2 29 participants

SAM-e for the Treatment of Depression in Patients With Parkinson's Disease

NYU Langone Health

NCT00070941

COMPLETED Phase 2 27 participants

A Study to Compare Pharmacokinetics and Pharmacodynamics of IPX066 to Standard Carbidopa-Levodopa

Impax Laboratories

NCT00869791

COMPLETED 27 participants

Trichloroethylene (TCE) Exposure in an Industrial Population

University of Kentucky

NCT00839514

COMPLETED Phase 2 27 participants

High-intensity Exercise and Fall Prevention Boot Camp for Parkinson's Disease

University of Nevada, Las Vegas

NCT02230267

COMPLETED Phase 2 27 participants

Preliminary Study of Piclozotan in Patients With Motor Complications Associated With Parkinson's Disease

Daiichi Sankyo

NCT00623363

COMPLETED 24 participants

Motor Skill Learning in People With Parkinson's Disease

National Institute of Neurological Disorders and Stroke (NINDS)

NCT00396942

COMPLETED Phase 4 23 participants

Methylphenidate for the Treatment of Gait Impairment in Parkinson's Disease

University of Cincinnati

NCT00526630

COMPLETED Phase 2 23 participants

Efficacy and Safety of AFQ056 When Combined With Increased Doses of L-dopa in Parkinson's Disease Patients With Moderate-severe L-dopa Induced Dyskinesia

Novartis

NCT01092065

COMPLETED Phase 2 23 participants

POETRY: Study of Estrogen Replacement Therapy in Postmenopausal Women With Parkinson's Disease

The Parkinson Study Group

NCT00234676

COMPLETED Phase 1 22 participants

A Randomized Trial to Evaluate Ampyra for Gait Impairment in Parkinson's Disease

University of Miami

NCT01491022

COMPLETED NA 21 participants

Automated Telehealth Diagnostics for Remote Parkinson Monitoring

Great Lakes NeuroTechnologies

NCT02152319

COMPLETED 21 participants

The Motor Network in Essential Tremor: Mechanisms of Therapy

University of Florida

NCT02712515

COMPLETED NA 20 participants

Memantine for Treatment of Cognitive Impairment in Patients With Parkinson's Disease and Dementia

Johns Hopkins University

NCT00294554

COMPLETED NA 20 participants

Deep Brain Stimulation in Patients With Parkinson's Disease

Mayo Clinic

NCT00586079

COMPLETED 20 participants

Study on the Effect of External Magnetic Stimulation on Patients With Parkinson's Disease

Parkinson's Disease Research, Education, and Clinical Center, Philadelphia

NCT00841464

COMPLETED NA 20 participants

Neuropsychiatric Effects of Deep Brain Stimulation in Patients With Parkinson's Disease

University of California, San Diego

NCT01306539

COMPLETED NA 20 participants

The Effect of Low Frequency STN DBS on Sleep and Vigilance in Parkinson's Disease (PD) Patients

University of Alabama at Birmingham

NCT01769690

COMPLETED 20 participants

Retrospective, Non-significant Risk, Deep Brain Stimulation (DBS) Care Management Software Feasibility Study

MedtronicNeuro

NCT01750242

COMPLETED NA 19 participants

Genetic Influences on Response to Gait Rehabilitation in Parkinson's Disease

VA Office of Research and Development

NCT03607695

COMPLETED 16 participants

Motion Immune Magnetic Resonance Imaging (MRI)

Duke University

NCT02302521

COMPLETED 14 participants

Using Parkinson's Disease to Study the Role of the Substantia Nigra Pars Reticulata

University of Colorado, Denver

NCT02216435

COMPLETED Phase 1 13 participants

Feasibility and Acceptability of a Physical Activity Behavior Change Intervention for Parkinson's Disease

Teachers College, Columbia University

NCT03696589

COMPLETED Phase 1 13 participants

Effects of a Dopamine Agonist on Pharmacodynamics of Levodopa in Parkinson's Disease

Oregon Health and Science University

NCT00666653

COMPLETED NA 13 participants

Video Based Mindfulness Based Stress Reduction

Oregon Health and Science University

NCT02705586

COMPLETED Phase 2 12 participants

Study of Magnetic Fields for Treatment of Parkinson's Disease

pico-tesla Magnetic Therapies

NCT00779155

COMPLETED Phase 2 12 participants

Comparison of IPX054 and Immediate-Release Carbidopa-Levodopa in Patients With Parkinson's Disease

Impax Laboratories

NCT00253084

COMPLETED Phase 3 10 participants

Study of KW-6002 (Istradefylline) in Parkinson's Disease in Patients With Motor Response Complications on Levodopa

University of Chicago

NCT00203957

COMPLETED 10 participants

Prospective Evaluation of Forceplate Measured Levodopa-Induced Dyskinesia

Oregon Health and Science University

NCT00912977

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Phase Distribution

PhaseTrial count
Phase 1 24
Phase 2 31
Phase 3 11
Phase 4 10

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Parkinson's Disease Trial Landscape

159 indexed Parkinson's Disease studies · 40 recruiting (25%).

Phase mix: 21 late (III/IV) vs 55 early (I/II).

Top sponsor: VA Office of Research and Development (16 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Parkinson's Disease?

PlainTrial tracks 159 US clinical trials for Parkinson's Disease, of which 40 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Parkinson's Disease?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.