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Parkinson's Disease clinical trials
40 of 159 indexed Parkinson's Disease trials are currently recruiting.
159 US clinical trials · 40 currently recruiting
Parkinson's Disease is the subject of 159 registered US clinical trials on ClinicalTrials.gov, 40 of them currently open to new participants. 21 are in Phase 3-4 (later-stage) and 55 in Phase 1-2 (earlier-stage). The most active sponsor is VA Office of Research and Development, running 16 of these trials.
The research picture
Parkinson's Disease has 159 registered US clinical trials, 40 of them open to new participants right now, about 25% of the total.
- 40
- recruiting participants now
- 25%
- of trials open to enrollment
- 21
- in Phase 3–4 (later-stage)
- 16
- top sponsor: VA Office of Research and Development
Active & Recent Trials
159 total, page 3 of 4
Evaluation of Safety and Tolerability of ENT-01 for the Treatment of Parkinson's Disease Related Constipation
Enterin
NCT03047629
Aripiprazole in Patients With Psychosis Associated With Parkinson's Disease
Otsuka Pharmaceutical Development & Commercialization
NCT00095810
Effects of Monoamine Reuptake Inhibitor NS2330 in Parkinson's Disease
National Institute of Neurological Disorders and Stroke (NINDS)
NCT00006077
The Effect of Rasagiline on Cognition in Parkinson's Disease
Brown University
NCT01382342
Selegiline to Zelapar Switch Study in Parkinson Disease Patients
Baylor College of Medicine
NCT00640159
Non-invasive Neurostimulation in Parkinson's Disease
Spaulding Rehabilitation Hospital
NCT01615718
GPR109A and Parkinson's Disease: Role of Niacin in Outcome Measures
VA Office of Research and Development
NCT03462680
The Effects of Dual Task Training in Individuals With Parkinson's Disease
The Cleveland Clinic
NCT02538029
Masked Faces in Parkinson Disease: Mechanism and Treatment
University of Florida
NCT00350402
Telephone-linked Home-based Exercise Training in PD
VA Office of Research and Development
NCT02898740
Psychiatric and Cognitive Manifestations of Parkinson's Disease
NYU Langone Health
NCT00360633
A Study of the Safety and Tolerability of a Single Dose Administration of CVT-301 (Levodopa Inhalation Powder)
Acorda Therapeutics
NCT02807675
A Double Blind Placebo Controlled Trial Evaluating Rasagiline Effects on Cognition in Parkinson's Disease Patients With Mild Cognitive Impairment Receiving Dopaminergic Therapy
Georgetown University
NCT01497652
Reducing Dyskinesia in Parkinson's Disease With Omega-3 Fatty Acids
VA Office of Research and Development
NCT01563913
Relative Bioavailability and Food Effect Study of CVN424
Cerevance Beta
NCT05635461
A Trial of Neurocognitive and Supportive Therapy Interventions for Individuals With Parkinson's Disease
Virginia Commonwealth University
NCT01646333
Poised for Parkinson's - an Intervention to Increase Embodied Agency in People With Parkinson's Disease and Their Carers
University of Idaho
NCT04726709
Non-contact Boxing Training and Traditional Therapeutic Exercise for Persons With Parkinson's Disease
University of Indianapolis
NCT01014663
Florbetapir F 18 PET Imaging of Beta-amyloid in Parkinson's Disease Patients
Avid Radiopharmaceuticals
NCT00857532
Dance Exercise as Novel Complementary Therapy for Parkinson's Disease
Beth Israel Deaconess Medical Center
NCT01163344
Rasagiline for the Symptomatic Treatment of Fatigue in Parkinson's Disease
University of Florida
NCT01168596
A Trial of 18F-AV-133 and 18F-AV-45 Positron Emission Tomography (PET)
Avid Radiopharmaceuticals
NCT01503944
SAM-e for the Treatment of Depression in Patients With Parkinson's Disease
NYU Langone Health
NCT00070941
A Study to Compare Pharmacokinetics and Pharmacodynamics of IPX066 to Standard Carbidopa-Levodopa
Impax Laboratories
NCT00869791
Trichloroethylene (TCE) Exposure in an Industrial Population
University of Kentucky
NCT00839514
High-intensity Exercise and Fall Prevention Boot Camp for Parkinson's Disease
University of Nevada, Las Vegas
NCT02230267
Preliminary Study of Piclozotan in Patients With Motor Complications Associated With Parkinson's Disease
Daiichi Sankyo
NCT00623363
Motor Skill Learning in People With Parkinson's Disease
National Institute of Neurological Disorders and Stroke (NINDS)
NCT00396942
Methylphenidate for the Treatment of Gait Impairment in Parkinson's Disease
University of Cincinnati
NCT00526630
Efficacy and Safety of AFQ056 When Combined With Increased Doses of L-dopa in Parkinson's Disease Patients With Moderate-severe L-dopa Induced Dyskinesia
Novartis
NCT01092065
POETRY: Study of Estrogen Replacement Therapy in Postmenopausal Women With Parkinson's Disease
The Parkinson Study Group
NCT00234676
A Randomized Trial to Evaluate Ampyra for Gait Impairment in Parkinson's Disease
University of Miami
NCT01491022
Automated Telehealth Diagnostics for Remote Parkinson Monitoring
Great Lakes NeuroTechnologies
NCT02152319
The Motor Network in Essential Tremor: Mechanisms of Therapy
University of Florida
NCT02712515
Memantine for Treatment of Cognitive Impairment in Patients With Parkinson's Disease and Dementia
Johns Hopkins University
NCT00294554
Deep Brain Stimulation in Patients With Parkinson's Disease
Mayo Clinic
NCT00586079
Study on the Effect of External Magnetic Stimulation on Patients With Parkinson's Disease
Parkinson's Disease Research, Education, and Clinical Center, Philadelphia
NCT00841464
Neuropsychiatric Effects of Deep Brain Stimulation in Patients With Parkinson's Disease
University of California, San Diego
NCT01306539
The Effect of Low Frequency STN DBS on Sleep and Vigilance in Parkinson's Disease (PD) Patients
University of Alabama at Birmingham
NCT01769690
Retrospective, Non-significant Risk, Deep Brain Stimulation (DBS) Care Management Software Feasibility Study
MedtronicNeuro
NCT01750242
Genetic Influences on Response to Gait Rehabilitation in Parkinson's Disease
VA Office of Research and Development
NCT03607695
Motion Immune Magnetic Resonance Imaging (MRI)
Duke University
NCT02302521
Using Parkinson's Disease to Study the Role of the Substantia Nigra Pars Reticulata
University of Colorado, Denver
NCT02216435
Feasibility and Acceptability of a Physical Activity Behavior Change Intervention for Parkinson's Disease
Teachers College, Columbia University
NCT03696589
Effects of a Dopamine Agonist on Pharmacodynamics of Levodopa in Parkinson's Disease
Oregon Health and Science University
NCT00666653
Video Based Mindfulness Based Stress Reduction
Oregon Health and Science University
NCT02705586
Study of Magnetic Fields for Treatment of Parkinson's Disease
pico-tesla Magnetic Therapies
NCT00779155
Comparison of IPX054 and Immediate-Release Carbidopa-Levodopa in Patients With Parkinson's Disease
Impax Laboratories
NCT00253084
Study of KW-6002 (Istradefylline) in Parkinson's Disease in Patients With Motor Response Complications on Levodopa
University of Chicago
NCT00203957
Prospective Evaluation of Forceplate Measured Levodopa-Induced Dyskinesia
Oregon Health and Science University
NCT00912977
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 24 |
| Phase 2 | 31 |
| Phase 3 | 11 |
| Phase 4 | 10 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Parkinson's Disease Trial Landscape
159 indexed Parkinson's Disease studies · 40 recruiting (25%).
Phase mix: 21 late (III/IV) vs 55 early (I/II).
Top sponsor: VA Office of Research and Development (16 trials), 9 others listed. 50 shown below, recruiting first.
How to read this condition's trial landscape
That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Parkinson's Disease?
PlainTrial tracks 159 US clinical trials for Parkinson's Disease, of which 40 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Parkinson's Disease?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.