Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.
Pain: full-pipeline trial registry
106 of 377 indexed Pain trials are currently recruiting.
Corpus placement: #16 of 28,707 conditions by registered trial count.
377 US clinical trials · 106 currently recruiting · #16 of 28,707 conditions by registered trial count
Pain: 377 US clinical trials tracked, 106 recruiting.
Pain is the subject of 377 registered US clinical trials on ClinicalTrials.gov, 106 of them currently open to new participants. 73 are in Phase 3-4 (later-stage) and 79 in Phase 1-2 (earlier-stage). The most active sponsor is University of Florida, running 9 of these trials.
Enrollment posture brief
Registry condition pain
OPEN 106 | RECR 28% | LATE 73 | EARLY 79 | RANK #16 | SPON 9
Volume-matched condition peers
Nearest open-share peer: Astigmatism (28% recruiting · 32 trials)
Pain lists 106 open slots (28% of 377 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Pain on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Pain is recruiting below its size-band peers.
106 of 377 indexed trials (28.1%) are open to enrollment, against a 37.1% average across 139 conditions with 100+ trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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Sponsorship of Pain trials is spread across many organizations.
University of Florida accounts for 9 of 377 trials (2.4%). 214 distinct sponsors appear on at least one study for this condition label.
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Typical Pain enrolment sits around 84 participants.
Median target enrolment is 84 among the 375 trials that report a genuine target (sentinel values excluded). 201 of those (53.6%) plan for fewer than 100 participants.
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Pain research is mostly interventional.
319 interventional and 58 observational studies make up this index (84.6% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
377 total, page 8 of 8
Virtual Reality Pain Neuroscience Education for Middle School Students
University of South Dakota
NCT04470375
Liposomal Bupivacaine (Exparel) for Postoperative Pain Control for Open and Laparoscopic Abdominal Hernia Repair
University of Kansas Medical Center
NCT02128646
Neuraxial and Neurolytic Analgesia for Intractable Pain
University of Wisconsin, Madison
NCT00167726
Investigating Botulinum Toxin A to Treat Acute Neck/Upper Shoulder Pain Following a New Spinal Cord Injury.
Craig Hospital
NCT00320281
Bioequivalency Study of Morphine Sulfate Injection, Solution and Tablet Under Fasted Conditions
Roxane Laboratories
NCT00994942
Pharmacokinetics and Safety of Bupivacaine HCl Spinal Block and EXPAREL Local Infiltration in Total Knee Arthroplasty
Pacira Pharmaceuticals
NCT02284386
Analgesic Efficacy of Smoked Cannabis
Center for Medicinal Cannabis Research
NCT00241579
VR for Pain Management During Adult Burn Dressing Change
Nationwide Children's Hospital
NCT04545229
A Pharmacokinetic Study to Compare Sustained Release and Standard Paracetamol Formulations.
GlaxoSmithKline
NCT01551797
INFUSE Morphine Study
Halozyme Therapeutics
NCT00593281
A Pilot Study of Switching From One Pain Medication to Another (Opioid Rotation)
Icahn School of Medicine at Mount Sinai
NCT00580294
Manual Therapy for the Treatment of Shoulder Pain for Overuse Syndrome Wheelchair Dependent Persons
Craig Hospital
NCT04991415
Veteran Ear Acupuncture Pilot Project
Chillicothe VA Medical Center
NCT04208659
Lidocaine Analgesia For Removal Of Wound Vac Dressings
University of Utah
NCT01126359
Usefulness of Acupuncture in Cancer Pain and Quality of Life
Southern California University of Health Sciences
NCT00401063
Bupivacaine Versus Lidocaine on Inflammatory Regulation
University of Maryland
NCT01060774
Low-Dose Opiate Therapy for Discomfort in Dementia (L-DOT)
VA Office of Research and Development
NCT00385684
Intranasal (NAS) Ketamine for Cancer Pain
Emory University
NCT03146806
Mindful Movement and Breathing to Improve Outcomes of Gynecologic Surgery
Wake Forest University Health Sciences
NCT01593657
Curcumin and Piperine in Reducing Inflammation for Ureteral Stent-Induced Symptoms in Patients With Cancer
Mayo Clinic
NCT02598726
Virtual Reality at End-of-life
State University of New York at Buffalo
NCT06149429
The Effects of Pain Neuroscience Education in a Spanish-Speaking Population
Shenandoah University
NCT03785353
Acupuncture for Vulvodynia: A Pre-pilot Study
University of Illinois at Chicago
NCT02704234
Helping Older Persons Emerge Stronger
Ohio State University
NCT02863081
Enriched Autologous Fat Grafting for Treating Pain at Amputation Sites
University of Pittsburgh
NCT01645722
Efficacy and Safety of Sublingual Fentanyl Tablets in Treatment of Breakthrough Pain in Cancer Patients.
Kyowa Kirin Co.
NCT00262678
Music Therapy to Ease Pain and Emotional Distress in Patients With Hematologic Cancer Who Are Undergoing High-Dose Therapy and Stem Cell Transplantation
Memorial Sloan Kettering Cancer Center
NCT00014482
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 40 |
| Phase 2 | 39 |
| Phase 3 | 36 |
| Phase 4 | 37 |
Top Sponsors
Named interventions
Most-linked intervention names on Pain records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Pain trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Pain page
377 registered trials, 106 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 106 Pain trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- University of Florida sponsors the most Pain trials on record, review their full trial history before evaluating a specific study. See University of Florida's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Pain condition card totals 377 registered trials; most-linked intervention Placebo; top US site state California. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.