Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT01574807 · ClinicalTrials.gov registry record · Phase 4
The Anesthetic Efficacy of 3% Mepivacaine Plus 2% Lidocaine With 1:100,000 Epinephrine for Lower Jaw Dental Injections
A Phase 4 study of Pain, sponsored by Ohio State University.
- Completed
- Registry status
- Phase 4
- Development phase
- 100
- Enrollment target
- 1
- Study location
NCT01574807: Completed Phase 4 study of Pain, sponsored by Ohio State University.
NCT01574807 is a Phase 4 study of Pain that has completed, run by Ohio State University. The registered enrollment target is 100 participants, below the 304-participant average among 374 other Pain trials with a reported enrollment target (67% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT01574807, a Phase 4 study of Pain, has completed, sponsored by Ohio State University.
- COMPLETED
- Registry status
- Phase 4
- Development phase
- 100 participants
- Enrollment target
- 1
- Study location
Study Summary
The inferior alveolar nerve block (shot) is the most frequently used injection technique for achieving local anesthesia (numbness) for the teeth in the lower jaw. However, this injection does not always result in successful pulpal (tooth) anesthesia (patient felt pain). No study has combined mepivacaine and lidocaine anesthetics (numbing solutions) for this type of injection (shot). The investigators propose to compare an injection of mepivacaine followed by lidocaine to an injection of lidocaine followed by lidocaine to determine if there is a difference in effectiveness.
Primary Outcome
An electric pulp tester will be used to test the lower jaw teeth (molars, premolars, and incisors) for anesthesia (numbness) in 4-minute time cycles for 60 minutes. Measurements of less than 80 on the EPT is considered not numb (anesthesia failure). Readings of 80 equate to anesthetic success.
Conditions Studied
Interventions
- DRUG mepivacaine + lidocaine followed by lidocaine +lidocaine
- DRUG lidocaine + lidocaine followed by mepivacaine + lidocaine
Study Locations (1)
Ohio
- The Ohio State University College of Dentistry, Postle Hall - Columbus
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 100 participants |
| Start Date | 2012-05 |
| Est. Completion | 2013-05 |
| Phase | Phase 4 |
What the finished NCT01574807 record still lists
NCT01574807 is an interventional study that assigns participants to a tested intervention. The registered 100 participants enrollment target is mid-sized for trials with a published cap, below the 304-participant average among 374 other Pain trials with a reported enrollment target (67% lower).
The record links to 1 condition, with Pain appearing as the primary indexed condition, and to 2 interventions - of which mepivacaine + lidocaine followed by lidocaine +lidocaine is the first listed.
NCT01574807 reports a single indexed study location in Ohio.
Frequently Asked Questions
What is clinical trial NCT01574807 about?
NCT01574807 is a clinical study titled "The Anesthetic Efficacy of 3% Mepivacaine Plus 2% Lidocaine With 1:100,000 Epinephrine for Lower Jaw Dental Injections". The inferior alveolar nerve block (shot) is the most frequently used injection technique for achieving local anesthesia (numbness) for the teeth in the lower jaw. However, this injection does not always result in successful pulpal (tooth) anesthesia (patient felt pain). No study has combined mepivac...
What is the current status of trial NCT01574807?
This trial is currently completed. It is a Phase 4 study. The enrollment target is 100 participants. The study started on 2012-05. Estimated completion is 2013-05.
What conditions does trial NCT01574807 study?
This clinical trial studies the following conditions: Pain.
What interventions are being tested in trial NCT01574807?
The interventions under investigation include: mepivacaine + lidocaine followed by lidocaine +lidocaine (DRUG), lidocaine + lidocaine followed by mepivacaine + lidocaine (DRUG).
Who is sponsoring clinical trial NCT01574807?
This trial is sponsored by Ohio State University, which has 552 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT01574807 being conducted?
This trial has 1 study location across Ohio. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Pain
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT01574807's enrollment target sits among peer trials
100 164th of 374 higher than 201 of 374 other Pain trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Pain trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
-
Effect of Magnesium on Neuromonitoring
RECRUITING · Phase 4
-
Low-Dose Ketamine Infusion During Burn Wound Care
RECRUITING · Phase 4
-
Optimizing Perioperative Analgesia to Lower Pain Following Cleft Palate Surgery
RECRUITING · Phase 4
-
Optimizing Pain Control in Transurethral Resection of the Prostate
RECRUITING · Phase 4
-
Low-dose Buccal Buprenorphine: Relative Abuse Potential and Analgesia
RECRUITING · Phase 4
-
Regional Blocks for Lateral Condyle Fractures
RECRUITING · Phase 4
Nationwide trials with similar profiles
Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.
Similar enrollment target
- NCT01048281 · 100 participants
Clinical & Pathological Studies of Upper Gastrointestinal Carcinoma
- NCT01161199 · 100 participants
The Use of Leukapheresis to Support HIV Pathogenesis Studies
- NCT01327690 · 100 participants · Early Phase 1
Mental Health in Veterans and Families After Group Therapies
- NCT01730781 · 100 participants
Imaging Cannabinoid Receptors Using Positron Emission Tomography (PET) Scanning
Similar registry start date
- NCT05988463 · started 2027-01-01 · Phase 1
Dose-Escalation Study of Artesunate Patients With IPF
- NCT07219706 · started 2026-12-10 · NA
Dietary Fiber and Time Restricted Eating
- NCT02831335 · started 2026-12-01
Technical Development of Multi-Parametric Renocerebral MRI
- NCT05962346 · started 2026-12 · NA
Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia