Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.
Pain: full-pipeline trial registry
106 of 377 indexed Pain trials are currently recruiting.
Corpus placement: #16 of 28,707 conditions by registered trial count.
377 US clinical trials · 106 currently recruiting · #16 of 28,707 conditions by registered trial count
Pain: 377 US clinical trials tracked, 106 recruiting.
Pain is the subject of 377 registered US clinical trials on ClinicalTrials.gov, 106 of them currently open to new participants. 73 are in Phase 3-4 (later-stage) and 79 in Phase 1-2 (earlier-stage). The most active sponsor is University of Florida, running 9 of these trials.
Enrollment posture brief
Registry condition pain
OPEN 106 | RECR 28% | LATE 73 | EARLY 79 | RANK #16 | SPON 9
Volume-matched condition peers
Nearest open-share peer: Astigmatism (28% recruiting · 32 trials)
Pain lists 106 open slots (28% of 377 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Pain on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Pain is recruiting below its size-band peers.
106 of 377 indexed trials (28.1%) are open to enrollment, against a 37.1% average across 139 conditions with 100+ trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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Sponsorship of Pain trials is spread across many organizations.
University of Florida accounts for 9 of 377 trials (2.4%). 214 distinct sponsors appear on at least one study for this condition label.
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Typical Pain enrolment sits around 84 participants.
Median target enrolment is 84 among the 375 trials that report a genuine target (sentinel values excluded). 201 of those (53.6%) plan for fewer than 100 participants.
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Pain research is mostly interventional.
319 interventional and 58 observational studies make up this index (84.6% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
377 total, page 4 of 8
A Prospective Clinical Outcomes Registry
Abbott Medical Devices
NCT01305525
Zoledronate in Treating Patients With Solid Tumors That Have Spread to the Bone
Novartis
NCT00003884
Study of MR-107A-02 for the Treatment of Acute Postoperative Pain Following Herniorrhaphy
Viatris Specialty
NCT06215859
To Evaluate the Safety and Efficacy of Acetaminophen 650 mg and 1000mg in Dental Pain After Surgery
McNeil Consumer Healthcare Division of McNEIL-PPC
NCT01115673
Assessment of Updated Educational Materials for Instanyl®
Takeda
NCT04938440
Psychosocial Pain Management During Addictions Treatment to Improve Outcomes
University of Michigan
NCT01372267
Self-Management Program for Persons With Limb Loss
Johns Hopkins Bloomberg School of Public Health
NCT00198692
A Randomized, Double-Blind Study of the Efficacy and Safety of Valdecoxib Compared to Placebo for Treatment of Post- Cholecystectomy Surgery Pain
Pfizer
NCT00661635
ACCESS (Access for Cancer Caregivers for Education and Support for Shared Decision Making)
Washington University School of Medicine
NCT02929108
Preventing Persistent Post-Surgical Pain and Dysfunction
Barbara A Rakel
NCT03965897
Radicle Relief 1: A Study of Health and Wellness Products on Pain and Other Health Outcomes
Radicle Science
NCT05589935
Safety and Efficacy of Dextromethorphan and Quinidine in the Treatment of the Pain of Diabetic Neuropathy
Avanir Pharmaceuticals
NCT00113620
Pragmatic Research of Acupuncture and Counseling eXtended to Inpatient Services
University of California, San Francisco
NCT03905720
REST: Reducing End-of-Life Symptoms With Touch
National Center for Complementary and Integrative Health (NCCIH)
NCT00065195
Evaluation of Loteprednol Etabonate Versus Vehicle for the Treatment of Inflammation and Pain Following Cataract Surgery
Bausch & Lomb Incorporated
NCT01060072
Sativex® for Relieving Persistent Pain in Patients With Advanced Cancer
Jazz Pharmaceuticals
NCT01361607
Trial Outcomes for Massage: Caregiver-Assisted vs. Therapist-Treated
VA Office of Research and Development
NCT03100539
Pain Quantification and Pain Management in Interventional Radiology (IR)
M.D. Anderson Cancer Center
NCT00500942
Protocolized vs Discretionary Use of Opioids in Acute Pain
Montefiore Medical Center
NCT00825370
Safety and Efficacy of Intravenous Hydromorphone in Elderly Emergency Department Patients With Acute Severe Pain
Montefiore Medical Center
NCT01429285
Biopsychosocial Factors' Influence on Shoulder Pain
University of Florida
NCT00187863
Efficacy and Safety of XG-102 in Reduction of Post-cataract Surgery Intraocular Inflammation
Xigen
NCT02235272
A Phase 2a, Proof-of-Concept Study of GIC-1001 in the Management of Visceral Pain During Sedation-Free, Full Colonoscopy
gicare Pharma
NCT01926444
Vapocoolant (Pain Ease Medium Stream) for Intravenous Lines in Emergency Department Patients
The Cleveland Clinic
NCT01670487
Primary Care Intervention to Reduce Prescription Opioid Overdoses
VA Office of Research and Development
NCT02464410
S1202: Duloxetine Hydrochloride for Muscle/Joint Pain in Early-Stage Breast Cancer Receiving Hormone Therapy
SWOG Cancer Research Network
NCT01598298
Safety of Pediatric COVID-19 Vaccination
Duke University
NCT05157191
Comprehensive vs. Assisted Management of Mood and Pain Symptoms
VA Office of Research and Development
NCT01757301
Ibuprofen Extended-Release Dental Pain Study
SCOLR Pharma
NCT00707057
Pain Control In First Trimester Medical Abortion: A Randomized Trial
Gynuity Health Projects
NCT01457521
Communication and Activation in Pain to Enhance Relationships and Treat Pain With Equity
VA Office of Research and Development
NCT03562793
A Study of Ketorolac for the Treatment of Inflammation and Pain Associated With Cataract Surgery
Allergan
NCT00524264
A Trial Assessing The Effectiveness and Safety of [S,S]-Reboxetine in Patients With Fibromyalgia
Pfizer
NCT00357825
Analgesic Efficacy & Safety of Intravenous (IV) Acetaminophen Versus Placebo for the Treatment of Postop Pain
Mallinckrodt
NCT00564486
Study of the Safety of BEMA™ Fentanyl Use for Breakthrough Pain in Cancer Subjects on Chronic Opioid Therapy
BioDelivery Sciences International
NCT00293020
Lidocaine Jelly for Pain Control During Mohs Surgery
Mayo Clinic
NCT03595449
Efficacy, Safety, and Pharmacokinetics of Femoral Nerve Block With EXPAREL in Total Knee Arthroplasty
Pacira Pharmaceuticals
NCT02713178
Duloxetine in Treating Peripheral Neuropathy Caused by Chemotherapy in Patients With Cancer
Alliance for Clinical Trials in Oncology
NCT00489411
Study Evaluating A Novel Ibuprofen Formulation In The Treatment Of Dental Pain
Pfizer
NCT01216163
Cognitive Testing for the Pain Quality Assessment Scale (PQAS)
University of Washington
NCT00715598
Fentanyl Transdermal Matrix Patch ZR-02-01 to Treat Chronic, Moderate to Severe Osteoarthritis (OA) Pain
ZARS Pharma
NCT00108771
Safety and Efficacy Study of Hydromorphone and Morphine
Montefiore Medical Center
NCT00195910
Symptom Management Efficacy Study to Reduce Distal Neuropathic Pain
New York University
NCT03855111
Insomnia Self-Management in Heart Failure
Yale University
NCT02660385
A Brief Patient-Controlled Intervention for a Symptom Cluster in Advanced Cancer
University of Wisconsin, Madison
NCT01954420
Quality IQ Patient Simulation Physician Practice Measurement and Engagement
Qure Healthcare
NCT03800901
Living With Sickle Cell Disease in the COVID-19 Pandemic
National Human Genome Research Institute (NHGRI)
NCT04417673
IV Acetaminophen for Postoperative Pain Analgesia After Laparoscopic Hysterectomy
University of Pittsburgh
NCT02400580
Video/Audio Distraction Analgesia for Simulated Oncology Procedure Pain
University of Washington
NCT00701571
Persistent Postoperative Pain and Joint Stiffness After Total Knee Arthroplasty Performed for Osteoarthritis
Hospital for Special Surgery, New York
NCT02626533
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 40 |
| Phase 2 | 39 |
| Phase 3 | 36 |
| Phase 4 | 37 |
Top Sponsors
Named interventions
Most-linked intervention names on Pain records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Pain trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Pain page
377 registered trials, 106 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 106 Pain trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- University of Florida sponsors the most Pain trials on record, review their full trial history before evaluating a specific study. See University of Florida's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Pain condition card totals 377 registered trials; most-linked intervention Placebo; top US site state California. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.