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Pain, Acute clinical trials
13 of 32 indexed Pain, Acute trials are currently recruiting.
32 US clinical trials · 13 currently recruiting
Pain, Acute is the subject of 32 registered US clinical trials on ClinicalTrials.gov, 13 of them currently open to new participants. 4 are in Phase 3-4 (later-stage) and 9 in Phase 1-2 (earlier-stage). The most active sponsor is Antonios Likourezos, running 2 of these trials.
The research picture
Pain, Acute has 32 registered US clinical trials, 13 of them open to new participants right now, about 41% of the total.
- 13
- recruiting participants now
- 41%
- of trials open to enrollment
- 4
- in Phase 3–4 (later-stage)
- 2
- top sponsor: Antonios Likourezos
Active & Recent Trials
32 total, page 1 of 1
Empathy Through Pain Control: Lidocaine Paracervical Block for IUD Placements
University of California, San Diego
NCT06960317
Variability in Analgesic Response to Ibuprofen
University of Pennsylvania
NCT06539741
RCT of Pain Perception With Fast and Slow Tenaculum Application
Women and Infants Hospital of Rhode Island
NCT05458037
Nebulized Ketamine to Nebulized Fentanyl for Treating Acute Painful Conditions in the ED
Antonios Likourezos
NCT06364540
Latinx Children and Surgery
University of California, Irvine
NCT06020677
Brain Mechanisms Supporting Cannabis-induced Pain Relief
University of California, San Diego
NCT04982965
TENS Analgesia During Outpatient Urethral Bulking for Stress Urinary Incontinence.
University of Rochester
NCT06369922
Phase 1 Study of SBS-147 in Healthy Adults
Sparian Biosciences
NCT07335913
Blue Light as an Anti-inflammatory and Analgesic Strategy in Thoracic Trauma
Rebecca E Kotcher, MD
NCT06626334
Valacyclovir in Pain Management of Acute Apical Abscesses
University of California, San Francisco
NCT05266040
fMRI and IVCM Cornea Microscopy of CXL in Keratoconus
Boston Children's Hospital
NCT04439552
TENS Unit for Analgesia During IUD Insertion
Tufts Medical Center
NCT06240260
Intranasal and Intravenous Oxytocin for Analgesia to Noxious Heat Pain
Wake Forest University Health Sciences
NCT07053774
EHR Precision Drug Treatment in Neonates
Children's Hospital Medical Center, Cincinnati
NCT04850079
Pectoral Nerve Blocks (PECs) for Cardiovascular Implantable Electronic Device Placement
Beth Israel Deaconess Medical Center
NCT05283980
Adult Oral Ibuprofen Study for ED Pain Patients
Antonios Likourezos
NCT03441269
Transverse Thoracic Plane Block in the Pediatric Cardiac Patient
Ochsner Health System
NCT04138745
Comparison of Three Different Pain Blocks for Subjects Undergoing VATS (Video Assisted Thoracoscopic Surgery) Procedure.
Indiana University
NCT03151434
Real-World Experience of Patients Treated for Musculoskeletal Injuries With SAM in Routine Care
ZetrOZ
NCT05254470
Preoperative Psychosocial Support for Postoperative Recovery and Health: Mechanistic Substudy
University of Utah
NCT04520958
Dose-Response Study of MR-107A-01 in The Treatment of Post-Surgical Dental Pain
Mylan
NCT04571515
Virtual Reality for Pain Management Study
University of Texas at Austin
NCT02997085
Vibration Analgesia in Propofol Infusion During Anesthesia Induction
Montefiore Medical Center
NCT03509857
Music to Reduce Patient Reported Pain During Intrauterine Device (IUD) Placement in the Office
Rutgers, The State University of New Jersey
NCT05068245
Virtual Reality Analgesia for Pediatric Burn Survivors
The University of Texas Medical Branch, Galveston
NCT03491657
The Effect of Touch on Pain and Anxiety During the Bone Marrow Biopsy Procedure
Dartmouth-Hitchcock Medical Center
NCT04935775
Ultrasound Guided Serratus Anterior Plane Block in ED Patients With Rib Fractures
Rhode Island Hospital
NCT06299137
Online Mindfulness-based Intervention to Prevent Chronic Pain
Florida State University
NCT04848428
OTC Naproxen and Acetaminophen Anti-Inflammatory Action in Dental Implant Patients
Hersh, Elliot V., DMD, MS, PhD
NCT04694300
Pharmacokinetics and Pharmacodynamics of TRV130, Morphine, and Placebo in Healthy Subjects
Trevena
NCT02083315
Magic Bowl Virtual Reality Analgesia
University of Washington
NCT07192822
RTMS for Treatment of Pain and Craving
Medical University of South Carolina
NCT03310138
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 4 |
| Phase 2 | 5 |
| Phase 3 | 1 |
| Phase 4 | 3 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Pain, Acute Trial Landscape
32 indexed Pain, Acute studies · 13 recruiting (41%).
Phase mix: 4 late (III/IV) vs 9 early (I/II).
Top sponsor: Antonios Likourezos (2 trials), 9 others listed. 32 shown below, recruiting first.
How to read this condition's trial landscape
That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Pain, Acute?
PlainTrial tracks 32 US clinical trials for Pain, Acute, of which 13 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Pain, Acute?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.