Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.
Pain, Acute: early-phase trial registry
13 of 32 indexed Pain, Acute trials are currently recruiting, with more weight in Phase 1-2.
Corpus placement: #477 of 28,707 conditions by registered trial count.
32 US clinical trials · 13 currently recruiting · #477 of 28,707 conditions by registered trial count
Pain, Acute: 32 US clinical trials tracked, 13 recruiting.
Pain, Acute is the subject of 32 registered US clinical trials on ClinicalTrials.gov, 13 of them currently open to new participants. 4 are in Phase 3-4 (later-stage) and 9 in Phase 1-2 (earlier-stage). The most active sponsor is Antonios Likourezos, running 2 of these trials.
Enrollment posture brief
Registry condition pain-acute
OPEN 13 | RECR 41% | LATE 4 | EARLY 9 | RANK #477 | SPON 2
Volume-matched condition peers
Nearest open-share peer: Pain Management (41% recruiting · 32 trials)
Pain, Acute lists 13 open slots (41% of 32 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Pain, Acute on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Pain, Acute recruits in line with its size-band peers.
13 of 32 indexed trials (40.6%) are open to enrollment, against a 39.7% average across 762 conditions with 20-99 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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Sponsorship of Pain, Acute trials is spread across many organizations.
Antonios Likourezos accounts for 2 of 32 trials (6.3%). 30 distinct sponsors appear on at least one study for this condition label.
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Typical Pain, Acute enrolment sits around 100 participants.
Median target enrolment is 100 among the 32 trials that report a genuine target (sentinel values excluded). 16 of those (50%) plan for fewer than 100 participants.
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Pain, Acute research is mostly interventional.
27 interventional and 5 observational studies make up this index (84.4% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
32 total, page 1 of 1
Empathy Through Pain Control: Lidocaine Paracervical Block for IUD Placements
University of California, San Diego
NCT06960317
Variability in Analgesic Response to Ibuprofen
University of Pennsylvania
NCT06539741
RCT of Pain Perception With Fast and Slow Tenaculum Application
Women and Infants Hospital of Rhode Island
NCT05458037
Nebulized Ketamine to Nebulized Fentanyl for Treating Acute Painful Conditions in the ED
Antonios Likourezos
NCT06364540
Latinx Children and Surgery
University of California, Irvine
NCT06020677
Brain Mechanisms Supporting Cannabis-induced Pain Relief
University of California, San Diego
NCT04982965
TENS Analgesia During Outpatient Urethral Bulking for Stress Urinary Incontinence.
University of Rochester
NCT06369922
Phase 1 Study of SBS-147 in Healthy Adults
Sparian Biosciences
NCT07335913
Blue Light as an Anti-inflammatory and Analgesic Strategy in Thoracic Trauma
Rebecca E Kotcher, MD
NCT06626334
Valacyclovir in Pain Management of Acute Apical Abscesses
University of California, San Francisco
NCT05266040
fMRI and IVCM Cornea Microscopy of CXL in Keratoconus
Boston Children's Hospital
NCT04439552
TENS Unit for Analgesia During IUD Insertion
Tufts Medical Center
NCT06240260
Intranasal and Intravenous Oxytocin for Analgesia to Noxious Heat Pain
Wake Forest University Health Sciences
NCT07053774
EHR Precision Drug Treatment in Neonates
Children's Hospital Medical Center, Cincinnati
NCT04850079
Pectoral Nerve Blocks (PECs) for Cardiovascular Implantable Electronic Device Placement
Beth Israel Deaconess Medical Center
NCT05283980
Adult Oral Ibuprofen Study for ED Pain Patients
Antonios Likourezos
NCT03441269
Transverse Thoracic Plane Block in the Pediatric Cardiac Patient
Ochsner Health System
NCT04138745
Comparison of Three Different Pain Blocks for Subjects Undergoing VATS (Video Assisted Thoracoscopic Surgery) Procedure.
Indiana University
NCT03151434
Real-World Experience of Patients Treated for Musculoskeletal Injuries With SAM in Routine Care
ZetrOZ
NCT05254470
Preoperative Psychosocial Support for Postoperative Recovery and Health: Mechanistic Substudy
University of Utah
NCT04520958
Dose-Response Study of MR-107A-01 in The Treatment of Post-Surgical Dental Pain
Mylan
NCT04571515
Virtual Reality for Pain Management Study
University of Texas at Austin
NCT02997085
Vibration Analgesia in Propofol Infusion During Anesthesia Induction
Montefiore Medical Center
NCT03509857
Music to Reduce Patient Reported Pain During Intrauterine Device (IUD) Placement in the Office
Rutgers, The State University of New Jersey
NCT05068245
Virtual Reality Analgesia for Pediatric Burn Survivors
The University of Texas Medical Branch, Galveston
NCT03491657
The Effect of Touch on Pain and Anxiety During the Bone Marrow Biopsy Procedure
Dartmouth-Hitchcock Medical Center
NCT04935775
Ultrasound Guided Serratus Anterior Plane Block in ED Patients With Rib Fractures
Rhode Island Hospital
NCT06299137
Online Mindfulness-based Intervention to Prevent Chronic Pain
Florida State University
NCT04848428
OTC Naproxen and Acetaminophen Anti-Inflammatory Action in Dental Implant Patients
Hersh, Elliot V., DMD, MS, PhD
NCT04694300
Pharmacokinetics and Pharmacodynamics of TRV130, Morphine, and Placebo in Healthy Subjects
Trevena
NCT02083315
Magic Bowl Virtual Reality Analgesia
University of Washington
NCT07192822
RTMS for Treatment of Pain and Craving
Medical University of South Carolina
NCT03310138
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 4 |
| Phase 2 | 5 |
| Phase 3 | 1 |
| Phase 4 | 3 |
Top Sponsors
Named interventions
Most-linked intervention names on Pain, Acute records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Pain, Acute trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Pain, Acute page
32 registered trials, 13 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 13 Pain, Acute trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- Antonios Likourezos sponsors the most Pain, Acute trials on record, review their full trial history before evaluating a specific study. See Antonios Likourezos's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Pain, Acute condition card totals 32 registered trials; most-linked intervention Placebo; top US site state California. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.