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NCT03441269 · ClinicalTrials.gov registry record · Phase 4
Adult Oral Ibuprofen Study for ED Pain Patients
A Phase 4 study of Pain, Acute, sponsored by Antonios Likourezos.
- Completed
- Registry status
- Phase 4
- Development phase
- 225
- Enrollment target
- 1
- Study location
NCT03441269: Completed Phase 4 study of Pain, Acute, sponsored by Antonios Likourezos.
NCT03441269 is a Phase 4 study of Pain, Acute that has completed, run by Antonios Likourezos. The registered enrollment target is 225 participants, above the 94-participant average among 31 other Pain, Acute trials with a reported enrollment target (139% higher). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT03441269, a Phase 4 study of Pain, Acute, has completed, sponsored by Antonios Likourezos.
- COMPLETED
- Registry status
- Phase 4
- Development phase
- 225 participants
- Enrollment target
- 1
- Study location
Study Summary
Ibuprofen is one of the most widely used non-steroidal anti-inflammatory drug (NSAID) for management of mild -to moderate pain in the ED (acute musculo-skeletal pain, headache, dental pain). Ibuprofen as a representative of NSAID's as a class follows the analgesic ceiling concept that postulates that there is a dose of a drug beyond which any further dosage increase results in no additional analgesic effect. Despite this fact, Ibuprofen may commonly be used at doses above its analgesic ceiling, although this may not offer an incremental analgesic advantage and potentially adds risk of harm. The analgesic ceiling dose for ibuprofen is only 200-400mg/dose, and about 1200 mg/day. Thus, we hypothesize that administration of Ibuprofen in a dose of 400 mg in the ED is as effective in treating mild-to-moderate acute pain in patients presenting to the ED as 600 mg and 800 mg
Primary Outcome
Difference in mean pain scores among all groups from at 60 minutes from baseline; negative difference infers decrease in pain score. A pain score of 10 indicates severe pain, 5 indicates moderate pain and 0 indicates no pain.
Conditions Studied
Interventions
- DRUG Oral Ibuprofen
Study Locations (1)
New York
- Maimonides Medical Center - Brooklyn
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 225 participants |
| Start Date | 2018-11-01 |
| Est. Completion | 2019-08-31 |
| Phase | Phase 4 |
What the finished NCT03441269 record still lists
NCT03441269 is an interventional study that assigns participants to a tested intervention. The registered 225 participants enrollment target is mid-sized for trials with a published cap, above the 94-participant average among 31 other Pain, Acute trials with a reported enrollment target (139% higher).
The record links to 1 condition, with Pain, Acute appearing as the primary indexed condition, and to 1 intervention - of which Oral Ibuprofen is the first listed.
NCT03441269 reports a single indexed study location in New York.
Frequently Asked Questions
What is clinical trial NCT03441269 about?
NCT03441269 is a clinical study titled "Adult Oral Ibuprofen Study for ED Pain Patients". Ibuprofen is one of the most widely used non-steroidal anti-inflammatory drug (NSAID) for management of mild -to moderate pain in the ED (acute musculo-skeletal pain, headache, dental pain). Ibuprofen as a representative of NSAID's as a class follows the analgesic ceiling concept that postulates tha...
What is the current status of trial NCT03441269?
This trial is currently completed. It is a Phase 4 study. The enrollment target is 225 participants. The study started on 2018-11-01. Estimated completion is 2019-08-31.
What conditions does trial NCT03441269 study?
This clinical trial studies the following conditions: Pain, Acute.
What interventions are being tested in trial NCT03441269?
The interventions under investigation include: Oral Ibuprofen (DRUG).
Who is sponsoring clinical trial NCT03441269?
This trial is sponsored by Antonios Likourezos, which has 33 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT03441269 being conducted?
This trial has 1 study location across New York. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Pain, Acute
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT03441269's enrollment target sits among peer trials
225 1st of 31 higher than 31 of 31 other Pain, Acute trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Pain, Acute trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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