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ClinicalTrials.gov 13 recruiting now official registry

Pain Management clinical trials

13 of 32 indexed Pain Management trials are currently recruiting.

32 US clinical trials · 13 currently recruiting

Pain Management is the subject of 32 registered US clinical trials on ClinicalTrials.gov, 13 of them currently open to new participants. 9 are in Phase 3-4 (later-stage) and 5 in Phase 1-2 (earlier-stage). The most active sponsor is Pacira Pharmaceuticals, running 3 of these trials.

The research picture

Pain Management has 32 registered US clinical trials, 13 of them open to new participants right now, about 41% of the total.

13
recruiting participants now
41%
of trials open to enrollment
9
in Phase 3–4 (later-stage)
3
top sponsor: Pacira Pharmaceuticals
Phase 12Phase 23Phase 36Phase 43

Active & Recent Trials

32 total, page 1 of 1

RECRUITING NA 400 participants

Does Patient Testimonial Improve the Pain Relief Derived From a Brief Intervention

Florida State University

NCT07335159

RECRUITING 220 participants

Assessment of Morbidity and Mortality Following Serratus Anterior Plane Block (SAPB) for Unilateral Rib Fractures

Albert Einstein College of Medicine

NCT07032766

RECRUITING Phase 3 210 participants

Suzetrigine in Total Hip Arthroplasty

Hospital for Special Surgery, New York

NCT07226700

RECRUITING Phase 3 170 participants

R.E.C.K vs Exparel in Robotic Nephrectomy

Wake Forest University Health Sciences

NCT07092566

RECRUITING Phase 4 130 participants

The Effect of Multimodal Pain Regimen on Use of Narcotics After Rotator Cuff Tear Repair

Montefiore Medical Center

NCT07076069

RECRUITING Phase 2 120 participants

Sub-dissociative Dose Ketamine in Treatment of Vaso-occlusive Pain Event in Children and Young Adults

Mohsen Saidinejad

NCT07369024

RECRUITING NA 100 participants

Post-Operative Analgesic Selection in Patients Planned for Third Molar Extraction After Undergoing Shared Decision Making Using 2- Versus 3-Option Decision-Aids

Rutgers, The State University of New Jersey

NCT07011472

RECRUITING Phase 4 90 participants

Efficacy of Methylprednisolone for Pain Control After ACL Repair

St. Louis University

NCT07158476

RECRUITING Phase 2 70 participants

Local Anesthesia for Facial Fractures

Washington University School of Medicine

NCT06429501

RECRUITING NA 60 participants

E-Tailored Pain Management Support for Dementia Family Caregivers: Feasibility of the PACE-app

University of Iowa

NCT07032350

RECRUITING NA 25 participants

mHealth Intervention for Pain Self Management

Virginia Commonwealth University

NCT07332377

RECRUITING Phase 2 15 participants

Psilocybin in Cancer Pain Study

Yvan Beaussant, MD, MSci

NCT06001749

RECRUITING NA 10 participants

Sensory Spinal Cord Stimulation

University of North Carolina, Chapel Hill

NCT07095036

ACTIVE NOT RECRUITING Phase 3 360 participants

Tramadol Versus Placebo and Morphine in the Management of Post-Operative Pain Abdominoplasty

Avenue Therapeutics

NCT03774836

ACTIVE NOT RECRUITING NA 360 participants

PEACE: Comparing Chronic Pain Treatment Options

Memorial Sloan Kettering Cancer Center

NCT02979574

ACTIVE NOT RECRUITING Phase 3 231 participants

Patient Controlled Epidural Analgesia Versus Intravenous Patient Controlled Analgesia for Post-Operative Pain Control in Patients Undergoing Elective Liver Resection

Memorial Sloan Kettering Cancer Center

NCT02523443

ACTIVE NOT RECRUITING NA 140 participants

COMmunity of Practice And Safety Support for Navigating Pain (COMPASS-NP)

Oregon Health and Science University

NCT05492903

ACTIVE NOT RECRUITING NA 15 participants

Wearable Focused Ultrasound Stimulation for Peripheral Nerve Pain Management

University of Texas at Austin

NCT07160049

COMPLETED NA 511 participants

Opioid-Free Orthopaedic Surgery

OrthoCarolina Research Institute

NCT04176783

COMPLETED NA 422 participants

The Alabama NSAIDs Patient Safety Survey, Phase II: Reducing Disparities in Risk Awareness and Communication

University of Alabama at Birmingham

NCT01352832

COMPLETED Phase 3 409 participants

Tramadol Versus Placebo in the Management of Postoperative Pain Following Bunionectomy

Avenue Therapeutics

NCT03290378

COMPLETED Phase 4 167 participants

Efficacy and Safety of EXPAREL Versus Standard of Care (SoC) in Subjects Undergoing Elective Cesarean Section

Pacira Pharmaceuticals

NCT03853694

COMPLETED Phase 3 167 participants

Phase 3 Adductor Canal Block With EXPAREL in Subjects Undergoing Primary Unilateral Total Knee Arthroplasty

Pacira Pharmaceuticals

NCT05139030

COMPLETED NA 105 participants

Post-partum Non-pharmacologic Pain Management

Wright State University

NCT03903172

COMPLETED NA 100 participants

Effectiveness of External Vibration for Pain Relief During Intravenous Access in Adult Patients

Kyle Stein

NCT03619135

COMPLETED NA 74 participants

Transcutaneous Electrical Nerve Stimulation (TENS) for Pain Control During Cervical Dilator Placement Prior to Dilation and Evacuation

Ashley Turner, MD

NCT03868787

COMPLETED NA 55 participants

Can Single-Injection Adductor Canal Blocks Improve PostOp Pain Relief in Patients Undergoing Total Knee Arthroplasty?

University of California, Irvine

NCT02276495

COMPLETED Phase 1 15 participants

PK Study of EXPAREL in Subjects Undergoing Open Spinal Fusion or Reconstructive Surgery

Pacira Pharmaceuticals

NCT02985762

COMPLETED Early Phase 1 15 participants

Erector Spinae Regional Anesthesia for Pain Control

The University of Texas Health Science Center at San Antonio

NCT05794828

COMPLETED NA 15 participants

A Non-invasive Intervention (BreEStim) for Management of Phantom Limb Pain (PLP) After Limb Amputation (Experiment 1)

The University of Texas Health Science Center, Houston

NCT04750525

COMPLETED NA 12 participants

Combined Peripheral (BreEStim) and Central Electrical Stimulation (tDCS) for Neuropathic Pain Management - Spinal Cord Injury

The University of Texas Health Science Center, Houston

NCT03302793

COMPLETED NA 6 participants

BreEStim and tDCS for Neuropathic Pain Management - Healthy Subjects

The University of Texas Health Science Center, Houston

NCT03302780

Phase Distribution

PhaseTrial count
Phase 1 2
Phase 2 3
Phase 3 6
Phase 4 3

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Pain Management Trial Landscape

32 indexed Pain Management studies · 13 recruiting (41%).

Phase mix: 9 late (III/IV) vs 5 early (I/II).

Top sponsor: Pacira Pharmaceuticals (3 trials), 9 others listed. 32 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Pain Management?

PlainTrial tracks 32 US clinical trials for Pain Management, of which 13 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Pain Management?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.