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NCT05266040 · ClinicalTrials.gov registry record · Phase 2
Valacyclovir in Pain Management of Acute Apical Abscesses
A Phase 2 study of Pain, Acute and Acute Apical Abscess, sponsored by University of California, San Francisco.
- Recruiting
- Registry status
- Phase 2
- Development phase
- 60
- Enrollment target
- 1
- Study location
NCT05266040: Recruiting Phase 2 study of Pain, Acute and Acute Apical Abscess, sponsored by University of California, San Francisco.
NCT05266040 is a Phase 2 study of Pain, Acute and Acute Apical Abscess that is actively recruiting participants, run by University of California, San Francisco. The registered enrollment target is 60 participants, below the 100-participant average among 31 other Pain, Acute trials with a reported enrollment target (40% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05266040, a Phase 2 study of Pain, Acute and Acute Apical Abscess, is actively recruiting participants, sponsored by University of California, San Francisco.
- RECRUITING
- Registry status
- Phase 2
- Development phase
- 60 participants
- Enrollment target
- 1
- Study location
Study Summary
The Virus in Endodontics (VE) phase I pilot study for preoperative pain will be analyzed and adjusted for the Phase II clinical trial. The Phase II clinical trial on preoperative pain, postoperative pain, and clinical healing will involve 250 patients. Patients will be recruited from the same pool of participants as the Phase II clinical trial. Preoperative cone beam computed tomography (CBCT) scans will be taken as well as three and six month postoperative CBCT scans. The secondary outcomes form the Phase II randomized clinical trial will be clinical success and visible radiographic healing determined by CBCT images.
Primary Outcome
Patients with an acute apical abscess circled the endodontic pain level from 0 to 10 .A predoctoral research assistant blinded to the study protocol phoned the study patients daily at a prearranged time to assess (1) pain level (Numerical Rating Scale \[NRS\]), and (2) analgesic use. NRS is a 1-dimensional scale that is quick and easily understood by patients. The NRS method assesses pain severity extremes, ranging from 0 to 10, and allows for both verbal (by telephone) and written administrati
Conditions Studied
Interventions
- DRUG Placebo
- DRUG Valacyclovir 500 MG
Study Locations (1)
California
- UCSF Dental - San Francisco
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 60 participants |
| Start Date | 2023-10-25 |
| Est. Completion | 2025-12-31 |
| Phase | Phase 2 |
What NCT05266040 shows while recruiting
NCT05266040 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 60 participants, a relatively small participant target, below the 100-participant average among 31 other Pain, Acute trials with a reported enrollment target (40% lower).
The record links to 2 conditions, with Pain, Acute appearing as the primary indexed condition, and to 2 interventions - of which Placebo is the first listed.
NCT05266040 reports a single indexed study location in California.
Frequently Asked Questions
What is clinical trial NCT05266040 about?
NCT05266040 is a clinical study titled "Valacyclovir in Pain Management of Acute Apical Abscesses". The Virus in Endodontics (VE) phase I pilot study for preoperative pain will be analyzed and adjusted for the Phase II clinical trial. The Phase II clinical trial on preoperative pain, postoperative pain, and clinical healing will involve 250 patients. Patients will be recruited from the same pool o...
What is the current status of trial NCT05266040?
This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 60 participants. The study started on 2023-10-25. Estimated completion is 2025-12-31.
What conditions does trial NCT05266040 study?
This clinical trial studies the following conditions: Pain, Acute, Acute Apical Abscess.
What interventions are being tested in trial NCT05266040?
The interventions under investigation include: Placebo (DRUG), Valacyclovir 500 MG (DRUG).
Who is sponsoring clinical trial NCT05266040?
This trial is sponsored by University of California, San Francisco, which has 1,713 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05266040 being conducted?
This trial has 1 study location across California. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT05266040's enrollment target sits among peer trials
60 22nd of 31 higher than 9 of 31 other Pain, Acute trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Pain, Acute trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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