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NCT04982965 · ClinicalTrials.gov registry record · Early Phase 1
Brain Mechanisms Supporting Cannabis-induced Pain Relief
A Early Phase 1 study of Pain, Acute, sponsored by University of California, San Diego.
- Recruiting
- Registry status
- Early Phase 1
- Development phase
- 100
- Enrollment target
- 2
- Study locations
NCT04982965: Recruiting Early Phase 1 study of Pain, Acute, sponsored by University of California, San Diego.
NCT04982965 is a Early Phase 1 study of Pain, Acute that is actively recruiting participants, run by University of California, San Diego. The registered enrollment target is 100 participants, roughly in line with the 98-participant average among 31 other Pain, Acute trials with a reported enrollment target. The trial reports 2 study locations across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04982965, a Early Phase 1 study of Pain, Acute, is actively recruiting participants, sponsored by University of California, San Diego.
- RECRUITING
- Registry status
- Early Phase 1
- Development phase
- 100 participants
- Enrollment target
- 2
- Study locations
Study Summary
The American Academy of Pain Medicine has labeled pain as a "silent epidemic" due to its staggering costs to society (over $500 billion/year) and widespread prevalence (affects over 100 million Americans). Thus, it is imperative to test and validate cost-effective pain therapies. To this extent, cannabis is characterized as one of the most promising therapies to treat a wide spectrum of pain conditions. However, the clinical applicability of cannabis-based pain therapies has been limited due to lacking mechanistic characterization in human-focused studies. Of critical importance, the neural mechanisms supporting cannabis induced pain relief remain unknown. The primary objective of the proposed pilot study is to identify the brain mechanisms supporting the direct alleviation of acutely evoked pain through vaporized cannabis.
Primary Outcome
Changes in brain blood flow and oxygen levels will be measured using non-invasive MRI-based brain imaging methods. These scans will assess how much blood is reaching brain tissue and how oxygen levels in the brain change over time.
Conditions Studied
Interventions
- DRUG Active Cannabis
- DRUG Placebo Cannabis
Study Locations (2)
California
- Altman Clinical and Translational Research Institute - La Jolla
- University of California, San Diego - San Diego
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 100 participants |
| Start Date | 2021-05-07 |
| Est. Completion | 2027-03-15 |
| Phase | Early Phase 1 |
What NCT04982965 shows while recruiting
NCT04982965 is an interventional study that assigns participants to a tested intervention. The registered 100 participants enrollment target is mid-sized for trials with a published cap, roughly in line with the 98-participant average among 31 other Pain, Acute trials with a reported enrollment target.
The record links to 1 condition, with Pain, Acute appearing as the primary indexed condition, and to 2 interventions - of which Active Cannabis is the first listed.
NCT04982965 reports a single indexed study location in California.
Frequently Asked Questions
What is clinical trial NCT04982965 about?
NCT04982965 is a clinical study titled "Brain Mechanisms Supporting Cannabis-induced Pain Relief". The American Academy of Pain Medicine has labeled pain as a "silent epidemic" due to its staggering costs to society (over $500 billion/year) and widespread prevalence (affects over 100 million Americans). Thus, it is imperative to test and validate cost-effective pain therapies. To this extent, ca...
What is the current status of trial NCT04982965?
This trial is currently recruiting. It is a Early Phase 1 study. The enrollment target is 100 participants. The study started on 2021-05-07. Estimated completion is 2027-03-15.
What conditions does trial NCT04982965 study?
This clinical trial studies the following conditions: Pain, Acute.
What interventions are being tested in trial NCT04982965?
The interventions under investigation include: Active Cannabis (DRUG), Placebo Cannabis (DRUG).
Who is sponsoring clinical trial NCT04982965?
This trial is sponsored by University of California, San Diego, which has 775 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT04982965 being conducted?
This trial has 2 study locations across California. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT04982965's enrollment target sits among peer trials
100 14th of 31 higher than 16 of 31 other Pain, Acute trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Pain, Acute trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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