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NCT02628795 · ClinicalTrials.gov registry record · NA

Overcoming TWEAK Signaling to Restore Muscle and Mobility After Joint Replacement

A NA study of Osteoarthritis, sponsored by University of Alabama at Birmingham.

Completed
Registry status
NA
Development phase
80
Enrollment target
1
Study location

NCT02628795: Completed NA study of Osteoarthritis, sponsored by University of Alabama at Birmingham.

NCT02628795 is a NA study of Osteoarthritis that has completed, run by University of Alabama at Birmingham. The registered enrollment target is 80 participants, below the 817-participant average among 135 other Osteoarthritis trials with a reported enrollment target (90% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.

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The verdict

NCT02628795, a NA study of Osteoarthritis, has completed, sponsored by University of Alabama at Birmingham.

COMPLETED
Registry status
NA
Development phase
80 participants
Enrollment target
1
Study location

Study Summary

This single-blind, randomized, controlled trial is designed to test the effect of an intensive, 16 week exercise rehabilitation program (progressive resistance training + functional mobility training) vs. usual care on restoration of muscle mass and mobility after total hip (THA) or knee (TKA) arthroplasty in men and women with end-stage osteoarthritis. The molecular basis underlying the trial is the presence of significant muscle inflammation susceptibility in many of these individuals, and the expectation that the more intensive intervention will overcome this inflammatory burden to facilitate recovery.

Primary Outcome

Primary muscle mass outcome of Aim 1

Conditions Studied

Osteoarthritis

Interventions

  • OTHER Usual Care
  • BEHAVIORAL PRT + FM

Study Locations (1)

Alabama

  • UAB Center for Exercise Medicine - Birmingham

Trial Details

FieldValue
Enrollment Target 80 participants
Start Date 2015-10
Est. Completion 2021-02-28
Phase NA
University of Alabama at Birmingham

1,160 total trials

What the finished NCT02628795 record still lists

NCT02628795 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 80 participants, a relatively small participant target, below the 817-participant average among 135 other Osteoarthritis trials with a reported enrollment target (90% lower).

The record links to 1 condition, with Osteoarthritis appearing as the primary indexed condition, and to 2 interventions - of which Usual Care is the first listed.

NCT02628795 reports a single indexed study location in Alabama.

Frequently Asked Questions

What is clinical trial NCT02628795 about?

NCT02628795 is a clinical study titled "Overcoming TWEAK Signaling to Restore Muscle and Mobility After Joint Replacement". This single-blind, randomized, controlled trial is designed to test the effect of an intensive, 16 week exercise rehabilitation program (progressive resistance training + functional mobility training) vs. usual care on restoration of muscle mass and mobility after total hip (THA) or knee (TKA) arthr...

What is the current status of trial NCT02628795?

This trial is currently completed. It is a NA study. The enrollment target is 80 participants. The study started on 2015-10. Estimated completion is 2021-02-28.

What conditions does trial NCT02628795 study?

This clinical trial studies the following conditions: Osteoarthritis.

What interventions are being tested in trial NCT02628795?

The interventions under investigation include: Usual Care (OTHER), PRT + FM (BEHAVIORAL).

Who is sponsoring clinical trial NCT02628795?

This trial is sponsored by University of Alabama at Birmingham, which has 1,160 total clinical trials registered on ClinicalTrials.gov.

Where is trial NCT02628795 being conducted?

This trial has 1 study location across Alabama. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Learn More About Clinical Trials

Similar trials for Osteoarthritis

Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.

Where NCT02628795's enrollment target sits among peer trials

80 99th of 135 higher than 35 of 135 other Osteoarthritis trials

participants (enrollment target), bucketed by value

Each bar is a band; taller bars hold more other Osteoarthritis trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.

Source ClinicalTrials.gov registry export · 2026-08-08

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Related registry views

Source: ClinicalTrials.gov NCT02628795, the US trial registry maintained by the National Library of Medicine. NCT02628795 (small enrollment · single site footprint · completed) retrieved and formatted by PlainTrial, see methodology.