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NCT04261049 · ClinicalTrials.gov registry record · Phase 1
Effect of Zilretta Injection
A Phase 1 study of Osteoarthritis, Knee, sponsored by University of North Carolina, Chapel Hill.
- Completed
- Registry status
- Phase 1
- Development phase
- 35
- Enrollment target
- 1
- Study location
NCT04261049: Completed Phase 1 study of Osteoarthritis, Knee, sponsored by University of North Carolina, Chapel Hill.
NCT04261049 is a Phase 1 study of Osteoarthritis, Knee that has completed, run by University of North Carolina, Chapel Hill. The registered enrollment target is 35 participants, below the 497-participant average among 112 other Osteoarthritis, Knee trials with a reported enrollment target (93% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04261049, a Phase 1 study of Osteoarthritis, Knee, has completed, sponsored by University of North Carolina, Chapel Hill.
- COMPLETED
- Registry status
- Phase 1
- Development phase
- 35 participants
- Enrollment target
- 1
- Study location
Study Summary
The purpose of this study is to examine the pre-post effects of a single ZILRETTA knee injection on physiological measures of self-reported pain and disability, physical performance, and physical activity in individuals with knee osteoarthritis (OA). The investigators will recruit 35 symptomatic knee OA patients for this study. All data will be collected prior to injection (baseline), as well as at 4 (post 1) and 8-week follow-ups (post 2).
Primary Outcome
Quadriceps strength was measured in Newton Meters normalized to body weight of the individuals. Strength was assessed in 90 degrees of knee flexion.
Conditions Studied
Interventions
- DRUG Triamcinolone Acetonide Extended-Release Injectable Suspension
Study Locations (1)
North Carolina
- MOTION Science Institute - Chapel Hill
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 35 participants |
| Start Date | 2020-08-01 |
| Est. Completion | 2022-01-10 |
| Phase | Phase 1 |
What the finished NCT04261049 record still lists
NCT04261049 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 35 participants, a relatively small participant target, below the 497-participant average among 112 other Osteoarthritis, Knee trials with a reported enrollment target (93% lower).
The record links to 1 condition, with Osteoarthritis, Knee appearing as the primary indexed condition, and to 1 intervention - of which Triamcinolone Acetonide Extended-Release Injectable Suspension is the first listed.
NCT04261049 reports a single indexed study location in North Carolina.
Frequently Asked Questions
What is clinical trial NCT04261049 about?
NCT04261049 is a clinical study titled "Effect of Zilretta Injection". The purpose of this study is to examine the pre-post effects of a single ZILRETTA knee injection on physiological measures of self-reported pain and disability, physical performance, and physical activity in individuals with knee osteoarthritis (OA). The investigators will recruit 35 symptomatic kne...
What is the current status of trial NCT04261049?
This trial is currently completed. It is a Phase 1 study. The enrollment target is 35 participants. The study started on 2020-08-01. Estimated completion is 2022-01-10.
What conditions does trial NCT04261049 study?
This clinical trial studies the following conditions: Osteoarthritis, Knee.
What interventions are being tested in trial NCT04261049?
The interventions under investigation include: Triamcinolone Acetonide Extended-Release Injectable Suspension (DRUG).
Who is sponsoring clinical trial NCT04261049?
This trial is sponsored by University of North Carolina, Chapel Hill, which has 1,109 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT04261049 being conducted?
This trial has 1 study location across North Carolina. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Osteoarthritis, Knee
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT04261049's enrollment target sits among peer trials
35 97th of 112 higher than 16 of 112 other Osteoarthritis, Knee trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Osteoarthritis, Knee trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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