Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT04391842 · ClinicalTrials.gov registry record · Phase 1
Sustained Acoustic Medicine (SAM) Combined With a Diclofenac Ultrasound Coupling Patch for Knee Osteoarthritis
A Phase 1 study of Osteoarthritis, Knee and Arthritis, sponsored by ZetrOZ.
- Completed
- Registry status
- Phase 1
- Development phase
- 34
- Enrollment target
- 1
- Study location
NCT04391842: Completed Phase 1 study of Osteoarthritis, Knee and Arthritis, sponsored by ZetrOZ.
NCT04391842 is a Phase 1 study of Osteoarthritis, Knee and Arthritis that has completed, run by ZetrOZ. The registered enrollment target is 34 participants, below the 497-participant average among 112 other Osteoarthritis, Knee trials with a reported enrollment target (93% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04391842, a Phase 1 study of Osteoarthritis, Knee and Arthritis, has completed, sponsored by ZetrOZ.
- COMPLETED
- Registry status
- Phase 1
- Development phase
- 34 participants
- Enrollment target
- 1
- Study location
Study Summary
The purpose of this study is to measure the effectiveness of Sustained Acoustic Medicine (SAM) treatment combined with diclofenac ultrasound coupling gel in patients with stage II and stage III knee osteoarthritis. The ability of the device to reduce pain, increase mobility, increase function of the affected leg, and improve quality of life in patients with knee osteoarthritis will be evaluated.
Primary Outcome
Change in the self described pain units on a scale by patient at baseline and post-treatment on the range of 0 - 10, 0 being the least pain and 10 being the worst pain.
Conditions Studied
Interventions
- COMBINATION_PRODUCT Sustained Acoustic Device with 1% Diclofenac patch
Study Locations (1)
New York
- Cayuga Medical Center - - Dryden
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 34 participants |
| Start Date | 2019-09-01 |
| Est. Completion | 2019-12-31 |
| Phase | Phase 1 |
What the finished NCT04391842 record still lists
NCT04391842 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 34 participants, a relatively small participant target, below the 497-participant average among 112 other Osteoarthritis, Knee trials with a reported enrollment target (93% lower).
The record links to 2 conditions, with Osteoarthritis, Knee appearing as the primary indexed condition, and to 1 intervention - of which Sustained Acoustic Device with 1% Diclofenac patch is the first listed.
NCT04391842 reports a single indexed study location in New York.
Frequently Asked Questions
What is clinical trial NCT04391842 about?
NCT04391842 is a clinical study titled "Sustained Acoustic Medicine (SAM) Combined With a Diclofenac Ultrasound Coupling Patch for Knee Osteoarthritis". The purpose of this study is to measure the effectiveness of Sustained Acoustic Medicine (SAM) treatment combined with diclofenac ultrasound coupling gel in patients with stage II and stage III knee osteoarthritis. The ability of the device to reduce pain, increase mobility, increase function of the...
What is the current status of trial NCT04391842?
This trial is currently completed. It is a Phase 1 study. The enrollment target is 34 participants. The study started on 2019-09-01. Estimated completion is 2019-12-31.
What conditions does trial NCT04391842 study?
This clinical trial studies the following conditions: Osteoarthritis, Knee, Arthritis.
What interventions are being tested in trial NCT04391842?
The interventions under investigation include: Sustained Acoustic Device with 1% Diclofenac patch (COMBINATION_PRODUCT).
Who is sponsoring clinical trial NCT04391842?
This trial is sponsored by ZetrOZ, which has 17 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT04391842 being conducted?
This trial has 1 study location across New York. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Osteoarthritis, Knee
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT04391842's enrollment target sits among peer trials
34 98th of 112 higher than 15 of 112 other Osteoarthritis, Knee trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Osteoarthritis, Knee trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
-
A Hip Flexion Feedback System for Exercise Monitoring in Individuals With Osteoarthritis and Obesity
RECRUITING · Phase 1
-
CBD for Knee Osteoarthritis
RECRUITING · Phase 1
-
Oral Steroid Taper After Total Knee Arthroplasty
RECRUITING · Phase 1
-
The Role of Vitamin K on Knee Osteoarthritis Outcomes
RECRUITING · Phase 1
-
Safety and Pharmacodynamics of GNSC-001 Intra-articular Injection for Knee Osteoarthritis
ACTIVE NOT RECRUITING · Phase 1
-
Prospective Evaluation of PRP and BMC Treatment to Accelerate Healing After ACL Reconstruction
ACTIVE NOT RECRUITING · Phase 1
Nationwide trials with similar profiles
Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.
Similar enrollment target
- NCT02897063 · 34 participants · Phase 1
Effects of Midodrine and Droxidopa on Splanchnic Capacitance in Autonomic Failure
- NCT03906617 · 34 participants · Phase 4
Bupivacaine/Epinephrine +Dexamethasone vs. Liposomal Bupivacaine
- NCT03992378 · 34 participants · NA
Neuromodulation to Regulate Inflammation and Autonomic Imbalance in Sepsis
- NCT04047849 · 34 participants · Phase 4
Latency Antibiotics in Previable PPROM, 18 0/7- 22 6/7 WGA
Similar registry start date
- NCT05962346 · started 2026-12 · NA
Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia
- NCT07125183 · started 2026-12 · Phase 2
Study on Efficacy and Tolerability of Weekly Doxorubicin in Elderly Patients With Advanced or Metastatic Leiomyosarcoma
- NCT07292298 · started 2026-11 · Phase 2
Phase 2 Single-Arm Rectal Cancer Brachytherapy for Patients With Low-Lying Residual Adenocarcinoma After Total Neoadjuvant Therapy to Improve Organ Preservation Rates
- NCT04263285 · started 2026-10 · NA
Treatment of Depression Post-SCI