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NCT05490446 · ClinicalTrials.gov registry record · Phase 2
A Study of Tebapivat (AG-946) in Participants With Anemia Due to Lower-Risk Myelodysplastic Syndromes (LR-MDS)
A Phase 2 study of Myelodysplastic Syndromes, sponsored by Agios Pharmaceuticals.
- Active
- Registry status
- Phase 2
- Development phase
- 87
- Enrollment target
- 20
- Study locations
NCT05490446: Active Phase 2 study of Myelodysplastic Syndromes, sponsored by Agios Pharmaceuticals.
NCT05490446 is a Phase 2 study of Myelodysplastic Syndromes that is active but no longer recruiting, run by Agios Pharmaceuticals. The registered enrollment target is 87 participants, below the 285-participant average among 173 other Myelodysplastic Syndromes trials with a reported enrollment target (69% lower). The trial reports 20 study locations across 15 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05490446, a Phase 2 study of Myelodysplastic Syndromes, is active but no longer recruiting, sponsored by Agios Pharmaceuticals.
- ACTIVE NOT RECRUITING
- Registry status
- Phase 2
- Development phase
- 87 participants
- Enrollment target
- 20
- Study locations
Study Summary
This purpose of this study is to establish proof of concept of tebapivat in participants with LR-MDS in Phase 2a and to evaluate the effect of tebapivat on transfusion independence (TI) in participants with LR-MDS in phase 2b.
Primary Outcome
Hb response is defined as a ≥1.5-grams per deciliter (g/dL) increase from baseline in the average Hb concentration from Week 8 through Week 16.
Conditions Studied
Interventions
- DRUG Tebapivat
Study Locations (20)
Other
- Fakultni nemocnice Ostrava - Ostrava
- CHRU Lille - Lille
- Hôpital Saint Louis - Paris
- University Hospital of Alexandroupolis - Alexandroupoli
California
- Innovative Clinical Research Institute Whittier - Lakewood
- David Geffen School of Medicine at UCLA - Los Angeles
- Emad Ibrahim, MD, Inc. - Redlands
Connecticut
- Smilow Cancer Hospital at Yale New Haven - New Haven
Florida
- Mayo Clinic Jacksonville - PPDS - Jacksonville
Illinois
- Edward H. Kaplan MD & Associates - Skokie
Missouri
- Washington University School of Medicine - St Louis
New York
- Memorial Sloan Kettering Cancer Center - Long Island City
North Carolina
- Duke Adult Blood and Marrow Clinic - Durham
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 87 participants |
| Start Date | 2022-11-07 |
| Est. Completion | 2029-03 |
| Phase | Phase 2 |
What the registry record for NCT05490446 still lists
NCT05490446 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 87 participants, a relatively small participant target, below the 285-participant average among 173 other Myelodysplastic Syndromes trials with a reported enrollment target (69% lower).
The record links to 1 condition, with Myelodysplastic Syndromes appearing as the primary indexed condition, and to 1 intervention - of which Tebapivat is the first listed.
NCT05490446 names 20 study sites across 15 states, led by Other, California, Connecticut.
Frequently Asked Questions
What is clinical trial NCT05490446 about?
NCT05490446 is a clinical study titled "A Study of Tebapivat (AG-946) in Participants With Anemia Due to Lower-Risk Myelodysplastic Syndromes (LR-MDS)". This purpose of this study is to establish proof of concept of tebapivat in participants with LR-MDS in Phase 2a and to evaluate the effect of tebapivat on transfusion independence (TI) in participants with LR-MDS in phase 2b.
What is the current status of trial NCT05490446?
This trial is currently active not recruiting. It is a Phase 2 study. The enrollment target is 87 participants. The study started on 2022-11-07. Estimated completion is 2029-03.
What conditions does trial NCT05490446 study?
This clinical trial studies the following conditions: Myelodysplastic Syndromes.
What interventions are being tested in trial NCT05490446?
The interventions under investigation include: Tebapivat (DRUG).
Who is sponsoring clinical trial NCT05490446?
This trial is sponsored by Agios Pharmaceuticals, which has 44 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05490446 being conducted?
This trial has 20 study locations across California, Connecticut, Florida, Illinois, Missouri. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Myelodysplastic Syndromes
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT05490446's enrollment target sits among peer trials
87 64th of 173 higher than 110 of 173 other Myelodysplastic Syndromes trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Myelodysplastic Syndromes trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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