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NCT07225868 · ClinicalTrials.gov registry record · NA
Prepare the Mind: Can Coaching in Goal-directed Behaviour Increase the Success of Cognitive Rehabilitation in People With MS?
A NA study of Multiple Sclerosis, sponsored by Universiteit Leiden.
- Recruiting
- Registry status
- NA
- Development phase
- 126
- Enrollment target
- 3
- Study locations
NCT07225868: Recruiting NA study of Multiple Sclerosis, sponsored by Universiteit Leiden.
NCT07225868 is a NA study of Multiple Sclerosis that is actively recruiting participants, run by Universiteit Leiden. The registered enrollment target is 126 participants, below the 585-participant average among 315 other Multiple Sclerosis trials with a reported enrollment target (78% lower). The trial reports 3 study locations across 2 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT07225868, a NA study of Multiple Sclerosis, is actively recruiting participants, sponsored by Universiteit Leiden.
- RECRUITING
- Registry status
- NA
- Development phase
- 126 participants
- Enrollment target
- 3
- Study locations
Study Summary
People with Multiple Sclerosis (MS) often experience cognitive difficulties such as memory problems, concentration issues, and reduced processing speed. These symptoms can have a negative impact on daily functioning and overall quality of life. Previous research on cognitive rehabilitation has shown that regular training focused on memory and concentration can have positive effects on cognitive functioning, including processing speed, memory, and executive functions that support daily activities. Moreover, fMRI studies (brain scans that measure brain activity) have revealed changes in brain activation following cognitive rehabilitation. Recently, the idea has emerged that a more personalized approach could improve treatment outcomes. Specifically, researchers have identified a link between personality traits and cognitive functioning. Since every individual is different, current cognitive rehabilitation programs often fail to take these personal differences into account. In this project, the investigators aim to enhance the effectiveness of cognitive rehabilitation by focusing more closely on individual characteristics through an app-based training program. Participants will complete a 12-week app training prior to a 6-week cognitive rehabilitation program. The first app focuses on mindset training, supported by a coach. Afterwards, all participants will use a second app designed to train processing speed and memory. In addition to cognitive functioning, the investigators will also examine psychological, (neuro)biological, and social changes using questionnaires and fMRI. This research may provide valuable insights into how cognitive functioning and quality of life in people with MS can be improved. This study is funded by the National MS Fund and is a collaboration between several institutions: the Department of Health, Medical and Neuropsychology at Leiden University (The Netherlands), the University at Buffalo (USA), and Reha Rheinfelden (Switzerland).
Primary Outcome
Objective cognitive changes between baseline and post intervention will be assessed using the Symbol Digit Modalities Test assessing information processing speed.
Conditions Studied
Interventions
- BEHAVIORAL Conscientiousness Coaching Before Cognitive Rehabilitation
- BEHAVIORAL Sham Intervention Before Cognitive Rehabilitation
Study Locations (3)
Other
- Health, Medical and Neuropsychology, Institute of Psychology, Faculty of Behvavioural and Social Siences, Leiden University - Leiden
- Research Department, Reha Rheinfelden - Rheinfelden
New York
- Jacobs School of Medicine and Biomedical Sciences, Neurology, University at Buffalo - Buffalo
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 126 participants |
| Start Date | 2025-11-01 |
| Est. Completion | 2028-12-31 |
| Phase | NA |
What NCT07225868 shows while recruiting
NCT07225868 is an interventional study that assigns participants to a tested intervention. The registered 126 participants enrollment target is mid-sized for trials with a published cap, below the 585-participant average among 315 other Multiple Sclerosis trials with a reported enrollment target (78% lower).
The record links to 1 condition, with Multiple Sclerosis appearing as the primary indexed condition, and to 2 interventions - of which Conscientiousness Coaching Before Cognitive Rehabilitation is the first listed.
NCT07225868 reports a single indexed study location in Other, New York.
Frequently Asked Questions
What is clinical trial NCT07225868 about?
NCT07225868 is a clinical study titled "Prepare the Mind: Can Coaching in Goal-directed Behaviour Increase the Success of Cognitive Rehabilitation in People With MS?". People with Multiple Sclerosis (MS) often experience cognitive difficulties such as memory problems, concentration issues, and reduced processing speed. These symptoms can have a negative impact on daily functioning and overall quality of life. Previous research on cognitive rehabilitation has shown...
What is the current status of trial NCT07225868?
This trial is currently recruiting. It is a NA study. The enrollment target is 126 participants. The study started on 2025-11-01. Estimated completion is 2028-12-31.
What conditions does trial NCT07225868 study?
This clinical trial studies the following conditions: Multiple Sclerosis.
What interventions are being tested in trial NCT07225868?
The interventions under investigation include: Conscientiousness Coaching Before Cognitive Rehabilitation (BEHAVIORAL), Sham Intervention Before Cognitive Rehabilitation (BEHAVIORAL).
Who is sponsoring clinical trial NCT07225868?
This trial is sponsored by Universiteit Leiden, which has 1 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT07225868 being conducted?
This trial has 3 study locations across New York. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Multiple Sclerosis
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT07225868's enrollment target sits among peer trials
126 105th of 315 higher than 210 of 315 other Multiple Sclerosis trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Multiple Sclerosis trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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