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A Study to Investigate Multiple Sclerosis Relapse Prevention With mRNA-1195 Compared With Placebo in Participants Aged 18 to ≤55 Years
NCT06735248 · View on ClinicalTrials.gov ↗
Study Summary
The primary objective of this trial is to evaluate the safety and reactogenicity of mRNA-1195 in participants with multiple sclerosis.
Conditions Studied
Interventions
- BIOLOGICAL Placebo
- BIOLOGICAL mRNA-1195
Study Locations (17)
Other
- North Bristol NHS Trust - Southmead Hospital — Bristol
- Cardiff and Vale University Health Board - University Hospital Wales — Cardiff
- Anne Rowling Regenerative Neurology Clinic, University of Edinburgh — Edinburgh
- NHS Greater Glasgow & Clyde - Institute of Neurological Sciences — Glasgow
- Cambridge Clinical Research Centre — London
- East Kent Hospitals University NHS Foundation Trust — London
- The Newcastle Upon Tyne Hospitals NHS Foundation Trust — Newcastle upon Tyne
- Sheffield Teaching Hospital NHS foundation Trust, Herries Road — Sheffield
Texas
- University of Texas Southwestern Medical Center — Dallas
- ANESC Research — El Paso
- Saturn Research Solutions — Plano
Missouri
- Sharlin Health & Neurology — Ozark
- Washington University School of Medicine Neurology Clinical Unit — St Louis
Massachusetts
- Boston Clinical Trials Inc - Internal Medicine — Boston
Michigan
- Quest Research Institute — Farmington Hills
Oklahoma
- Oklahoma Medical Research Foundation (OMRF) MS Center of Excellence — Oklahoma City
Queensland
- University of the Sunshine Coast Clinical Trials — Birtinya
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 180 participants |
| Start Date | 2025-04-16 |
| Est. Completion | 2029-01-08 |
| Phase | Phase 2 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT06735248
The ClinicalTrials.gov registry entry for NCT06735248 describes a study currently listed as recruiting. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 180 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is ModernaTX, which has 67 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 1 condition, with Multiple Sclerosis appearing as the primary indexed condition, and to 2 interventions — of which Placebo is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT06735248 reports 17 study locations spanning 7 distinct geographic areas — top geographies include Other, Texas, Missouri. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT06735248 about?
NCT06735248 is a clinical study titled "A Study to Investigate Multiple Sclerosis Relapse Prevention With mRNA-1195 Compared With Placebo in Participants Aged 18 to ≤55 Years". The primary objective of this trial is to evaluate the safety and reactogenicity of mRNA-1195 in participants with multiple sclerosis.
What is the current status of trial NCT06735248?
This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 180 participants. The study started on 2025-04-16. Estimated completion is 2029-01-08.
What conditions does trial NCT06735248 study?
This clinical trial studies the following conditions: Multiple Sclerosis. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT06735248?
The interventions under investigation include: Placebo (BIOLOGICAL), mRNA-1195 (BIOLOGICAL). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT06735248?
This trial is sponsored by ModernaTX, which has 67 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT06735248 being conducted?
This trial has 17 study locations across Massachusetts, Michigan, Missouri, Oklahoma, Texas. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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