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A Study to Investigate the Safety, Tolerability, and Processing by the Body of Intravenous and Subcutaneous RO7121932 Administration in Participants With Multiple Sclerosis
NCT05704361 · View on ClinicalTrials.gov ↗
Study Summary
The primary purpose of the study is to evaluate the safety and tolerability of a single-ascending intravenous (IV) dose (Part 1), a single-ascending subcutaneous (SC) dose (Part 2), and multiple ascending SC doses (Part 3) of RO7121932 in participants with multiple sclerosis (MS).
Conditions Studied
Interventions
- DRUG RO7121932 IV
- DRUG RO7121932 SC
Study Locations (20)
Other
- Cliniques Universitaires St-Luc — Brussels
- UZ Gent — Ghent
- Universitätsklinikum "Carl Gustav Carus" — Dresden
- Universitätsmedizin Göttingen Georg-August-Universität — Göttingen
- Klinikum rechts der Isar der TU Muenchen — München
- Universitätsklinikum Münster Klinik u. Poliklinik f. Neurologie — Münster
- Universitätsklinikum Tübingen, Zentrum für Neurologie — Tübingen
- Universitätsklinikum Ulm — Ulm
- Hadassah University Hospital - Ein Kerem — Jerusalem
- Tel Aviv Sourasky Medical Center — Tel Aviv
- ARENSIA Exploratory Medicine Phase I, PMSI Republican Clinical Hospital — Chisinau
- Uniwersyteckie Centrum Kliniczne — Gda?sk
Lombardy
- IRCCS Ospedale San Raffaele — Milan
- Fond. Istituto Neurologico C.Besta — Milan
California
- Stanford University Medical Center — Stanford
Connecticut
- Yale University Multiple Sclerosis Center — New Haven
Florida
- University of South Florida — Tampa
Massachusetts
- University of Massachusetts Medical School — Worcester
Ohio
- UC Health, LLC. — Cincinnati
Quebec
- Montreal Neurological Institute and Hospital — Montreal
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 129 participants |
| Start Date | 2021-08-11 |
| Est. Completion | 2027-07-08 |
| Phase | Phase 1 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT05704361
The ClinicalTrials.gov registry entry for NCT05704361 describes a study currently listed as recruiting. It is categorized as Phase 1, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 129 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Hoffmann-La Roche, which has 758 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 1 condition, with Multiple Sclerosis appearing as the primary indexed condition, and to 2 interventions — of which RO7121932 IV is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT05704361 reports 20 study locations spanning 8 distinct geographic areas — top geographies include Other, Lombardy, California. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT05704361 about?
NCT05704361 is a clinical study titled "A Study to Investigate the Safety, Tolerability, and Processing by the Body of Intravenous and Subcutaneous RO7121932 Administration in Participants With Multiple Sclerosis". The primary purpose of the study is to evaluate the safety and tolerability of a single-ascending intravenous (IV) dose (Part 1), a single-ascending subcutaneous (SC) dose (Part 2), and multiple ascending SC doses (Part 3) of RO7121932 in participants with multiple sclerosis (MS).
What is the current status of trial NCT05704361?
This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 129 participants. The study started on 2021-08-11. Estimated completion is 2027-07-08.
What conditions does trial NCT05704361 study?
This clinical trial studies the following conditions: Multiple Sclerosis. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT05704361?
The interventions under investigation include: RO7121932 IV (DRUG), RO7121932 SC (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT05704361?
This trial is sponsored by Hoffmann-La Roche, which has 758 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT05704361 being conducted?
This trial has 20 study locations across California, Connecticut, Florida, Massachusetts, Ohio. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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