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ClinicalTrials.gov 15 recruiting now official registry

Metastatic Non Small Cell Lung Cancer clinical trials

15 of 31 indexed Metastatic Non Small Cell Lung Cancer trials are currently recruiting.

31 US clinical trials · 15 currently recruiting

Metastatic Non Small Cell Lung Cancer is the subject of 31 registered US clinical trials on ClinicalTrials.gov, 15 of them currently open to new participants. 11 are in Phase 3-4 (later-stage) and 18 in Phase 1-2 (earlier-stage). The most active sponsor is ArriVent BioPharma, running 3 of these trials.

The research picture

Metastatic Non Small Cell Lung Cancer has 31 registered US clinical trials, 15 of them open to new participants right now, about 48% of the total.

15
recruiting participants now
48%
of trials open to enrollment
11
in Phase 3–4 (later-stage)
3
top sponsor: ArriVent BioPharma
Phase 110Phase 28Phase 311

Active & Recent Trials

31 total, page 1 of 1

RECRUITING Phase 3 1,410 participants

A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Chemotherapy in Adult Participants With Locally Advanced or Metastatic Non-Small Cell Lung Cancer

Pfizer

NCT07222566

RECRUITING Phase 2 806 participants

Phase 2 Trial of Adagrasib Monotherapy and in Combination With Pembrolizumab and a Phase 3 Trial of Adagrasib in Combination in Patients With a KRAS G12C Mutation KRYSTAL-7

Mirati Therapeutics

NCT04613596

RECRUITING Phase 3 744 participants

A Study to Investigate the Efficacy and Safety of Dato-DXd With or Without Osimertinib Compared With Platinum Based Doublet Chemotherapy in Participants With EGFR-Mutated Locally Advanced or Metastatic Non-Small Cell Lung Cancer

AstraZeneca

NCT06417814

RECRUITING Phase 3 740 participants

Study of Dato-DXd Plus Pembrolizumab vs Pembrolizumab Alone in the First-line Treatment of Subjects With Advanced or Metastatic NSCLC Without Actionable Genomic Alterations

Daiichi Sankyo

NCT05215340

RECRUITING Phase 3 734 participants

LUNAR-2: TTFields With Pembrolizumab + Platinum-based Chemotherapy for Metastatic NSCLC

NovoCure

NCT06216301

RECRUITING Phase 2 571 participants

Osimertinib Alone or With Chemotherapy for EGFR-Mutant Lung Cancers

Memorial Sloan Kettering Cancer Center

NCT04410796

RECRUITING Phase 3 480 participants

Study to Evaluate Efficacy and Safety of Firmonertinib Compared With Investigator's Choice of EGFR Inhibitor as First-Line Treatment in Participants Who Have Locally Advanced or Metastatic NSCLC With EGFR P-Loop and Alpha C-Helix Compressing (PACC) Uncommon Mutations

ArriVent BioPharma

NCT07185997

RECRUITING Phase 1 250 participants

Open-label Study of BBO-8520 in Adult Subjects With KRASG12C Non-small Cell Lung Cancer

TheRas, Inc., d/b/a BBOT (BridgeBio Oncology Therapeutics)

NCT06343402

RECRUITING Phase 1 188 participants

STC-15 as a Part of Combination Therapy With Toripalimab in Selected Advanced Cancers

STORM Therapeutics

NCT06975293

RECRUITING Phase 2 170 participants

Autologous LN-145 in Patients With Metastatic Non-Small-Cell Lung Cancer

Iovance Biotherapeutics

NCT04614103

RECRUITING Phase 1 52 participants

Safety and Efficacy of OBX-115 in Advanced Solid Tumors

Obsidian Therapeutics

NCT06060613

RECRUITING Phase 2 40 participants

Reduced CT + Anti-PD-1 as First Line Tx in Vulnerable Older Adults w/Adv <50% PD-L1 Non-Small Cell Lung Cancer (NSCLC)

Virginia Commonwealth University

NCT06731413

RECRUITING Phase 1 30 participants

A Study of Therapeutic Drug Monitoring-Based Atezolizumab Dosing

National Cancer Institute (NCI)

NCT06066138

RECRUITING Phase 1 10 participants

MOv19-BBz CAR T Cells in FRa+ Cancers

University of Pennsylvania

NCT07116057

RECRUITING Phase 1 5 participants

A Study of CD8+ T Cell Imaging During Treatment in People With Non-Small Cell Lung Cancer

Memorial Sloan Kettering Cancer Center

NCT06863233

ACTIVE NOT RECRUITING Phase 3 1,200 participants

A Global Study of Volrustomig (MEDI5752) Plus Chemotherapy Versus Pembrolizumab Plus Chemotherapy for Participants With Metastatic Non-small Cell Lung Cancer.

AstraZeneca

NCT05984277

ACTIVE NOT RECRUITING Phase 3 1,170 participants

Datopotamab Deruxtecan (Dato-DXd) and Pembrolizumab With or Without Platinum Chemotherapy in 1L Non-Small Cell Lung Cancer (TROPION-Lung07)

Daiichi Sankyo

NCT05555732

ACTIVE NOT RECRUITING Phase 3 545 participants

A Study of Ramucirumab (LY3009806) in Combination With Erlotinib in Previously Untreated Participants With EGFR Mutation-Positive Metastatic NSCLC (RELAY)

Eli Lilly and Company

NCT02411448

ACTIVE NOT RECRUITING Phase 2 468 participants

A Study of Relatlimab Plus Nivolumab in Combination With Chemotherapy vs. Nivolumab in Combination With Chemotherapy as First Line Treatment for Participants With Stage IV or Recurrent Non-small Cell Lung Cancer (NSCLC)

Bristol-Myers Squibb

NCT04623775

ACTIVE NOT RECRUITING Phase 3 453 participants

Phase 3 Study of MRTX849 (Adagrasib) vs Docetaxel in Patients With Advanced Non-Small Cell Lung Cancer With KRAS G12C Mutation

Mirati Therapeutics

NCT04685135

ACTIVE NOT RECRUITING Phase 2 400 participants

A Study of Tislelizumab in Combination With Investigational Agents in Participants With Non-Small Cell Lung Cancer

BeiGene

NCT05635708

ACTIVE NOT RECRUITING Phase 3 398 participants

Study to Compare Furmonertinib to Platinum-Based Chemotherapy for Patients With Locally Advanced or Metastatic Non-Small Cell Lung Cancer (NSCLC) With Epidermal Growth Factor Receptor (EGFR) Exon 20 Insertion Mutations (FURVENT)

ArriVent BioPharma

NCT05607550

ACTIVE NOT RECRUITING Phase 3 377 participants

A Study of Subcutaneous (SC) Pembrolizumab Coformulated With Berahyaluronidase Alfa (MK-3475A) vs Intravenous Pembrolizumab in Adult Participants With Metastatic Non-small Cell Lung Cancer (NSCLC) (MK-3475A-D77)

Merck Sharp & Dohme

NCT05722015

ACTIVE NOT RECRUITING Phase 1 160 participants

Study of Furmonertinib in Patients With Advanced or Metastatic Non-Small Cell Lung Cancer (NSCLC) With Activating, Including Uncommon, Epidermal Growth Factor Receptor (EGFR) or Human Epidermal Growth Factor Receptor 2 (HER2) Mutations

ArriVent BioPharma

NCT05364073

ACTIVE NOT RECRUITING 100 participants

Long-term Outcomes Among Patients With Programmed Death-ligand 1 <1% Metastatic Non-small Cell Lung Cancer Treated With First-line Nivolumab + Ipilimumab + 2 Cycles of Chemotherapy

Bristol-Myers Squibb

NCT07024862

ACTIVE NOT RECRUITING Phase 2 40 participants

Plasma-Adapted First-Line Pembro In NSCLC

Julia K. Rotow, MD

NCT04166487

ACTIVE NOT RECRUITING Phase 1 33 participants

Dupilumab_Metastatic NSCLC

Thomas Marron

NCT05013450

ACTIVE NOT RECRUITING Phase 1 27 participants

Safety and Efficacy of Combining APL-101 With Frontline Osimertinib in Patients With EGFR-mutated Metastatic Non-small Cell Lung Cancer (NSCLC)

Washington University School of Medicine

NCT04743505

COMPLETED Phase 2 121 participants

A Study of INCMGA00012 in Participants With Selected Solid Tumors (POD1UM-203)

Incyte Corporation

NCT03679767

COMPLETED 68 participants

Real-World Assessment of Clinical Outcomes in Metastatic NSCLC Patients With MET Exon 14 Skipping Mutation and Brain Metastases Treated With Capmatinib

Novartis Pharmaceuticals

NCT05675683

COMPLETED Phase 1 22 participants

Study of Dacomitinib and Osimertinib for Patients With Advanced EGFR Mutant Lung Cancer

Memorial Sloan Kettering Cancer Center

NCT03810807

Phase Distribution

PhaseTrial count
Phase 1 10
Phase 2 8
Phase 3 11

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Metastatic Non Small Cell Lung Cancer Trial Landscape

31 indexed Metastatic Non Small Cell Lung Cancer studies · 15 recruiting (48%).

Phase mix: 11 late (III/IV) vs 18 early (I/II).

Top sponsor: ArriVent BioPharma (3 trials), 9 others listed. 31 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Metastatic Non Small Cell Lung Cancer?

PlainTrial tracks 31 US clinical trials for Metastatic Non Small Cell Lung Cancer, of which 15 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Metastatic Non Small Cell Lung Cancer?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.