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Study to Compare Furmonertinib to Platinum-Based Chemotherapy for Patients With Locally Advanced or Metastatic Non-Small Cell Lung Cancer (NSCLC) With Epidermal Growth Factor Receptor (EGFR) Exon 20 Insertion Mutations (FURVENT)
NCT05607550 · View on ClinicalTrials.gov ↗
Study Summary
Global, Phase 3, randomized, multicenter, open-label study evaluating the efficacy and safety of furmonertinib (firmonertinib) at 2 dose levels (160 mg once daily \[QD\] and 240 mg QD) compared to platinum-based chemotherapy in previously untreated patients with locally advanced or metastatic non-squamous Non-Small Cell Lung Cancer (NSCLC) with Epidermal Growth Factor Receptor (EGFR) exon 20 insertion mutations. A target of approximately 375 patients will be randomized in a 1:1:1 ratio to treatment with furmonertinib 240 mg QD, furmonertinib 160 mg QD, or platinum-based chemotherapy.
Conditions Studied
Interventions
- DRUG furmonertinib 240 mg oral, daily
- DRUG furmonertinib 160 mg oral, daily
- DRUG platinum-based chemotherapy
Study Locations (20)
California
- Arrivent Investigative Site — Beverly Hills
- Arrivent Investigative Site — Fullerton
- Arrivent Investigative Site — Long Beach
- Arrivent Investigative Site — Los Alamitos
- Arrivent Investigative Site — Napa
- Arrivent Investigative Site — Orange
- Arrivent Investigative Site — Orange
- Arrivent Investigative site — Sacramento
- Arrivent Investigative Site — San Diego
- Arrivent Investigative Site — Santa Barbara
- Arrivent Investigative Site — Santa Monica
- Arrivent Investigative Site — Santa Rosa
- Arrivent Investigative Site — Whittier
Connecticut
- Arrivent Investigative Site — Hartford
- Arrivent Investigative Site — Norwich
Florida
- Arrivent Investigative Site — Fort Myers
- Arrivent Investigative Site — St. Petersburg
Alabama
- Arrivent Investigative Site — Daphne
Arizona
- Arrivent Investigative Site — Yuma
Arkansas
- Arrivent Investigative Site — Fayetteville
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 398 participants |
| Start Date | 2023-06-01 |
| Est. Completion | 2028-02-15 |
| Phase | Phase 3 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT05607550
The ClinicalTrials.gov registry entry for NCT05607550 describes a study currently listed as active not recruiting. It is categorized as Phase 3, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 398 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is ArriVent BioPharma, which has 35 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 3 conditions, with Advanced Non-Small Cell Lung Cancer appearing as the primary indexed condition, and to 3 interventions — of which furmonertinib 240 mg oral, daily is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT05607550 reports 20 study locations spanning 6 distinct geographic areas — top geographies include California, Connecticut, Florida. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT05607550 about?
NCT05607550 is a clinical study titled "Study to Compare Furmonertinib to Platinum-Based Chemotherapy for Patients With Locally Advanced or Metastatic Non-Small Cell Lung Cancer (NSCLC) With Epidermal Growth Factor Receptor (EGFR) Exon 20 Insertion Mutations (FURVENT)". Global, Phase 3, randomized, multicenter, open-label study evaluating the efficacy and safety of furmonertinib (firmonertinib) at 2 dose levels (160 mg once daily \[QD\] and 240 mg QD) compared to platinum-based chemotherapy in previously untreated patients with locally advanced or metastatic non-sq...
What is the current status of trial NCT05607550?
This trial is currently active not recruiting. It is a Phase 3 study. The enrollment target is 398 participants. The study started on 2023-06-01. Estimated completion is 2028-02-15.
What conditions does trial NCT05607550 study?
This clinical trial studies the following conditions: Advanced Non-Small Cell Lung Cancer, Metastatic Non-Small Cell Lung Cancer, EGFR Exon 20 Mutations. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT05607550?
The interventions under investigation include: furmonertinib 240 mg oral, daily (DRUG), furmonertinib 160 mg oral, daily (DRUG), platinum-based chemotherapy (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT05607550?
This trial is sponsored by ArriVent BioPharma, which has 35 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT05607550 being conducted?
This trial has 20 study locations across Alabama, Arizona, Arkansas, California, Connecticut. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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