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Autologous LN-145 in Patients With Metastatic Non-Small-Cell Lung Cancer
NCT04614103 · View on ClinicalTrials.gov ↗
Study Summary
This is a prospective, open-label, multi-cohort, non-randomized, multicenter phase 2 study evaluating LN-145 in patients with metastatic non-small-cell lung cancer
Conditions Studied
Interventions
- BIOLOGICAL LN-145
Study Locations (20)
Florida
- University of Florida Health Cancer Center — Gainesville
- Sylvester Comprehensive Cancer Center — Miami
- AdventHealth Cancer Institute — Orlando
- H Lee Moffitt Cancer Center and Research Institute — Tampa
California
- City of Hope — Duarte
- UC San Diego Moores Cancer Center — La Jolla
- University of Southern California — Los Angeles
Illinois
- Rush University Medical Center — Chicago
- University of Illinois Hospital & Health Sciences System — Chicago
- Advocate Aurora Health — Park Ridge
Kentucky
- University of Kentucky-Markey Cancer Center — Lexington
- University of Louisville — Louisville
Michigan
- Karmanos Cancer Institute — Detroit
- Henry Ford Health System — Detroit
Delaware
- Christiana Care Health System — Newark
Georgia
- Augusta University — Augusta
Maryland
- University of Maryland — Baltimore
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 170 participants |
| Start Date | 2021-05-07 |
| Est. Completion | 2031-12 |
| Phase | Phase 2 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT04614103
The ClinicalTrials.gov registry entry for NCT04614103 describes a study currently listed as recruiting. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 170 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Iovance Biotherapeutics, which has 128 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 1 condition, with Metastatic Non Small Cell Lung Cancer appearing as the primary indexed condition, and to 1 intervention — of which LN-145 is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT04614103 reports 20 study locations spanning 11 distinct geographic areas — top geographies include Florida, California, Illinois. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT04614103 about?
NCT04614103 is a clinical study titled "Autologous LN-145 in Patients With Metastatic Non-Small-Cell Lung Cancer". This is a prospective, open-label, multi-cohort, non-randomized, multicenter phase 2 study evaluating LN-145 in patients with metastatic non-small-cell lung cancer
What is the current status of trial NCT04614103?
This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 170 participants. The study started on 2021-05-07. Estimated completion is 2031-12.
What conditions does trial NCT04614103 study?
This clinical trial studies the following conditions: Metastatic Non Small Cell Lung Cancer. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT04614103?
The interventions under investigation include: LN-145 (BIOLOGICAL). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT04614103?
This trial is sponsored by Iovance Biotherapeutics, which has 128 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT04614103 being conducted?
This trial has 20 study locations across California, Delaware, Florida, Georgia, Illinois. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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