Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
A Study of Tislelizumab in Combination With Investigational Agents in Participants With Non-Small Cell Lung Cancer
NCT05635708 · View on ClinicalTrials.gov ↗
Study Summary
The purpose of this study is to assess the antitumor activity, safety, and tolerability of tislelizumab plus investigational agent(s) with or without chemotherapy. This study is structured as a master protocol with separate sub- studies. Sub-study 1 includes participants with non-small cell lung cancer (NSCLC) with high programmed cell death protein ligand-1 (PD-L1) expression (≥ 50%), and Sub-study 2 includes participants with NSCLC with low or negative (PD-L1) expression (\< 50%).
Conditions Studied
Interventions
- DRUG Carboplatin
- DRUG Cisplatin
- DRUG Tislelizumab
- DRUG LBL-007
- DRUG BGB-A445
Study Locations (20)
Other
- Hospital de Amor Barretos — Barretos
- Hospital Do Cancer de Londrina — Londrina
- Centro Gaucho Integrado de Oncologia Hospital Mae de Deus — Porto Alegre
- Fundacao Faculdade Regional de Medicina de Sao Jose Do Rio Preto — São José do Rio Preto
- Icesp Instituto Do Cancer Do Estado de Sao Paulo Octavio Frias de Oliveira — São Paulo
New South Wales
- Blacktown Cancer and Haematology Centre — Blacktown
- Chris Obrien Lifehouse — Camperdown
- Northern Beaches Hospital — Frenchs Forest
- Port Macquarie Base Hospital — Port Macquarie
Western Australia
- One Clinical Research — Nedlands
- St John of God Health Care — Subiaco
California
- Valkyrie Clinical Trials — Los Angeles
Massachusetts
- Massachusetts General Hospital — Boston
New York
- Memorial Sloan Kettering Cancer Center Mskcc — New York
Oregon
- Providence Portland Medical Center — Portland
Texas
- The University of Texas Md Anderson Cancer Center — Houston
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 400 participants |
| Start Date | 2023-03-07 |
| Est. Completion | 2026-10 |
| Phase | Phase 2 |
Interested in This Trial?
Always speak with your doctor before enrolling in a clinical trial.
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT05635708
The ClinicalTrials.gov registry entry for NCT05635708 describes a study currently listed as active not recruiting. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 400 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is BeiGene, which has 91 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 2 conditions, with Non-small Cell Lung Cancer appearing as the primary indexed condition, and to 5 interventions — of which Carboplatin is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT05635708 reports 20 study locations spanning 12 distinct geographic areas — top geographies include Other, New South Wales, Western Australia. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT05635708 about?
NCT05635708 is a clinical study titled "A Study of Tislelizumab in Combination With Investigational Agents in Participants With Non-Small Cell Lung Cancer". The purpose of this study is to assess the antitumor activity, safety, and tolerability of tislelizumab plus investigational agent(s) with or without chemotherapy. This study is structured as a master protocol with separate sub- studies. Sub-study 1 includes participants with non-small cell lung can...
What is the current status of trial NCT05635708?
This trial is currently active not recruiting. It is a Phase 2 study. The enrollment target is 400 participants. The study started on 2023-03-07. Estimated completion is 2026-10.
What conditions does trial NCT05635708 study?
This clinical trial studies the following conditions: Non-small Cell Lung Cancer, Metastatic Non-small Cell Lung Cancer. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT05635708?
The interventions under investigation include: Carboplatin (DRUG), Cisplatin (DRUG), Tislelizumab (DRUG), LBL-007 (DRUG), BGB-A445 (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT05635708?
This trial is sponsored by BeiGene, which has 91 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT05635708 being conducted?
This trial has 20 study locations across California, Massachusetts, New York, Oregon, Texas. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
How Clinical Trials Work
Understand phases 1-4, trial design, randomization, and the informed consent process.
Patient Rights in Clinical Trials
Your rights as a participant: consent, withdrawal, privacy, and who to contact.
Finding the Right Clinical Trial
A practical guide to searching trials, understanding eligibility, and evaluating options.
All Guides
Browse our complete library of clinical trial educational resources.
Read our methodology — how this data is sourced, computed, and verified.