Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
Study of Furmonertinib in Patients With Advanced or Metastatic Non-Small Cell Lung Cancer (NSCLC) With Activating, Including Uncommon, Epidermal Growth Factor Receptor (EGFR) or Human Epidermal Growth Factor Receptor 2 (HER2) Mutations
NCT05364073 · View on ClinicalTrials.gov ↗
Study Summary
This is a Phase 1b, open-label, multi-center, dose-escalation and dose expansion study designed to evaluate the safety, pharmacokinetics (PK), and preliminary antitumor activity of furmonertinib in patients with advanced or metastatic non-small cell lung cancer (NSCLC) with activating, including uncommon, Epidermal Growth Factor Receptor (EGFR) or Human Epidermal Growth Factor Receptor 2 (HER2) mutations. Patients will be enrolled into one of 2 stages: Stage 1 (Dose Escalation and Backfill Cohorts) and Stage 2 (Dose Expansion).
Conditions Studied
Interventions
- DRUG Furmonertinib
Study Locations (20)
California
- ArriVent Investigative Site — Sacramento
- ArriVent Investigative Site — Whittier
New South Wales
- ArriVent Investigative Site — Blacktown
- ArriVent Investigative Site — St Leonards
Other
- Arrivent Investigative Site — Edmonton
- Arrivent Investigative Site — Toronto
Beijing Municipality
- Allist Investigative Site — Beijing
- Allist Investigative Site — Chaoyang
Henan
- Allist Investigative Site — Zhengzhou
- Allist Investigative Site — Zhengzhou
Arizona
- ArriVent Investigative Site — Prescott
Florida
- ArriVent Investigative Site — Celebration
Michigan
- ArriVent Investigative Site — Detroit
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 160 participants |
| Start Date | 2022-06-30 |
| Est. Completion | 2026-12-31 |
| Phase | Phase 1 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT05364073
The ClinicalTrials.gov registry entry for NCT05364073 describes a study currently listed as active not recruiting. It is categorized as Phase 1, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 160 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is ArriVent BioPharma, which has 35 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 6 conditions, with Non-Small Cell Lung Cancer (NSCLC) appearing as the primary indexed condition, and to 1 intervention — of which Furmonertinib is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT05364073 reports 20 study locations spanning 15 distinct geographic areas — top geographies include California, New South Wales, Other. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT05364073 about?
NCT05364073 is a clinical study titled "Study of Furmonertinib in Patients With Advanced or Metastatic Non-Small Cell Lung Cancer (NSCLC) With Activating, Including Uncommon, Epidermal Growth Factor Receptor (EGFR) or Human Epidermal Growth Factor Receptor 2 (HER2) Mutations". This is a Phase 1b, open-label, multi-center, dose-escalation and dose expansion study designed to evaluate the safety, pharmacokinetics (PK), and preliminary antitumor activity of furmonertinib in patients with advanced or metastatic non-small cell lung cancer (NSCLC) with activating, including unc...
What is the current status of trial NCT05364073?
This trial is currently active not recruiting. It is a Phase 1 study. The enrollment target is 160 participants. The study started on 2022-06-30. Estimated completion is 2026-12-31.
What conditions does trial NCT05364073 study?
This clinical trial studies the following conditions: Non-Small Cell Lung Cancer (NSCLC), Advanced Non-Small Cell Lung Cancer, Metastatic Non-Small Cell Lung Cancer, EGFR Exon 20 Mutations, HER2 Exon 20 Mutations. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT05364073?
The interventions under investigation include: Furmonertinib (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT05364073?
This trial is sponsored by ArriVent BioPharma, which has 35 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT05364073 being conducted?
This trial has 20 study locations across Arizona, California, Florida, Michigan, Texas. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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