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RECRUITING Phase 3

LUNAR-2: TTFields With Pembrolizumab + Platinum-based Chemotherapy for Metastatic NSCLC

NCT06216301 · View on ClinicalTrials.gov ↗

Study Summary

This study, known as LUNAR-2, aims to investigate the effectiveness and safety of using TTFields, delivered by the NovoTTF-200T device, concomitantly administered with pembrolizumab and platinum-based chemotherapy for patients with advanced non-small cell lung cancer that has spread to other parts of the body. The primary goals of the study are to assess overall survival and progression-free survival. Secondary objectives include analyzing outcomes based on the specific histology (subtype) of the lung cancer.

Interventions

  • DRUG Pembrolizumab
  • DEVICE NovoTTF-200T
  • DRUG Platinum based chemotherapy

Study Locations (20)

Illinois

  • Northwest Oncology & Hematology — Barrington
  • Elmhurst Hospital Nancy Knowles Cancer Center — Elmhurst
  • Edward Cancer Center — Naperville
  • Cancer Treatment Centers of America (CTCA) — Zion

Missouri

  • Luminis Health Radiation Oncology - Anne Arundel Health System — Annapolis
  • University of Kansas Cancer Center - North — Kansas City
  • University of Kansas Cancer Center - Lee's Summit — Lee's Summit
  • University of Kansas Cancer Center - Overland Park — Overland

California

  • St. Jude Herritage Medical Group — Fullerton
  • Hoag Family Cancer Institute - Hoag Memorial Hospital — Newport Beach
  • Sutter Institute for Medical Research — Sacramento

New York

  • New York Cancer & Blood Specialists (NYCBS) — New Hyde Park
  • New York Cancer & Blood Specialists (NYCBS) — New York
  • University of Rochester Medical Center — Rochester

Florida

  • Florida Cancer Affiliates - Ocala Oncology — Ocala
  • Moffitt Cancer Center — Tampa

Alabama

  • Central Alabama Research — Birmingham

Arizona

  • Western Regional Medical Center, LLC — Goodyear

Indiana

  • Franciscan Health Indianapolis — Indianapolis

Trial Details

FieldValue
Enrollment Target 734 participants
Start Date 2024-07-31
Est. Completion 2028-10
Phase Phase 3

Sponsor

NovoCure

32 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT06216301

The ClinicalTrials.gov registry entry for NCT06216301 describes a study currently listed as recruiting. It is categorized as Phase 3, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 734 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is NovoCure, which has 32 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Metastatic Non-small Cell Lung Cancer appearing as the primary indexed condition, and to 3 interventions — of which Pembrolizumab is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT06216301 reports 20 study locations spanning 9 distinct geographic areas — top geographies include Illinois, Missouri, California. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT06216301 about?

NCT06216301 is a clinical study titled "LUNAR-2: TTFields With Pembrolizumab + Platinum-based Chemotherapy for Metastatic NSCLC". This study, known as LUNAR-2, aims to investigate the effectiveness and safety of using TTFields, delivered by the NovoTTF-200T device, concomitantly administered with pembrolizumab and platinum-based chemotherapy for patients with advanced non-small cell lung cancer that has spread to other parts o...

What is the current status of trial NCT06216301?

This trial is currently recruiting. It is a Phase 3 study. The enrollment target is 734 participants. The study started on 2024-07-31. Estimated completion is 2028-10.

What conditions does trial NCT06216301 study?

This clinical trial studies the following conditions: Metastatic Non-small Cell Lung Cancer. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT06216301?

The interventions under investigation include: Pembrolizumab (DRUG), NovoTTF-200T (DEVICE), Platinum based chemotherapy (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT06216301?

This trial is sponsored by NovoCure, which has 32 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT06216301 being conducted?

This trial has 20 study locations across Alabama, Arizona, California, Florida, Illinois. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial