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NCT06216301 · ClinicalTrials.gov registry record · Phase 3
LUNAR-2: TTFields With Pembrolizumab + Platinum-based Chemotherapy for Metastatic NSCLC
A Phase 3 study of Metastatic Non Small Cell Lung Cancer, sponsored by NovoCure.
- Recruiting
- Registry status
- Phase 3
- Development phase
- 734
- Enrollment target
- 20
- Study locations
NCT06216301: Recruiting Phase 3 study of Metastatic Non Small Cell Lung Cancer, sponsored by NovoCure.
NCT06216301 is a Phase 3 study of Metastatic Non Small Cell Lung Cancer that is actively recruiting participants, run by NovoCure. The registered enrollment target is 734 participants, above the 359-participant average among 31 other Metastatic Non Small Cell Lung Cancer trials with a reported enrollment target (104% higher). The trial reports 20 study locations across 9 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06216301, a Phase 3 study of Metastatic Non Small Cell Lung Cancer, is actively recruiting participants, sponsored by NovoCure.
- RECRUITING
- Registry status
- Phase 3
- Development phase
- 734 participants
- Enrollment target
- 20
- Study locations
Study Summary
This study, known as LUNAR-2, aims to investigate the effectiveness and safety of using TTFields, delivered by the NovoTTF-200T device, concomitantly administered with pembrolizumab and platinum-based chemotherapy for patients with advanced non-small cell lung cancer that has spread to other parts of the body. The primary goals of the study are to assess overall survival and progression-free survival. Secondary objectives include analyzing outcomes based on the specific histology (subtype) of the lung cancer.
Primary Outcome
To compare OS in subjects treated with TTFields concomitant with pembrolizumab and platinum-based chemotherapy compared to OS of those treated with pembrolizumab and platinum-based chemotherapy alone (superiority analysis).
Conditions Studied
Interventions
- DRUG Pembrolizumab
- DEVICE NovoTTF-200T
- DRUG Platinum based chemotherapy
Study Locations (20)
Illinois
- Northwest Oncology & Hematology - Barrington
- Elmhurst Hospital Nancy Knowles Cancer Center - Elmhurst
- Edward Cancer Center - Naperville
- Cancer Treatment Centers of America (CTCA) - Zion
Missouri
- Luminis Health Radiation Oncology - Anne Arundel Health System - Annapolis
- University of Kansas Cancer Center - North - Kansas City
- University of Kansas Cancer Center - Lee's Summit - Lee's Summit
- University of Kansas Cancer Center - Overland Park - Overland
California
- St. Jude Herritage Medical Group - Fullerton
- Hoag Family Cancer Institute - Hoag Memorial Hospital - Newport Beach
- Sutter Institute for Medical Research - Sacramento
New York
- New York Cancer & Blood Specialists (NYCBS) - New Hyde Park
- New York Cancer & Blood Specialists (NYCBS) - New York
- University of Rochester Medical Center - Rochester
Florida
- Florida Cancer Affiliates - Ocala Oncology - Ocala
- Moffitt Cancer Center - Tampa
Alabama
- Central Alabama Research - Birmingham
Arizona
- Western Regional Medical Center, LLC - Goodyear
Indiana
- Franciscan Health Indianapolis - Indianapolis
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 734 participants |
| Start Date | 2024-07-31 |
| Est. Completion | 2028-10 |
| Phase | Phase 3 |
What NCT06216301 shows while recruiting
NCT06216301 is an interventional study that assigns participants to a tested intervention. The registered 734 participants enrollment target is mid-sized for trials with a published cap, above the 359-participant average among 31 other Metastatic Non Small Cell Lung Cancer trials with a reported enrollment target (104% higher).
The record links to 1 condition, with Metastatic Non Small Cell Lung Cancer appearing as the primary indexed condition, and to 3 interventions - of which Pembrolizumab is the first listed.
NCT06216301 names 20 study sites across 9 states, led by Illinois, Missouri, California.
Frequently Asked Questions
What is clinical trial NCT06216301 about?
NCT06216301 is a clinical study titled "LUNAR-2: TTFields With Pembrolizumab + Platinum-based Chemotherapy for Metastatic NSCLC". This study, known as LUNAR-2, aims to investigate the effectiveness and safety of using TTFields, delivered by the NovoTTF-200T device, concomitantly administered with pembrolizumab and platinum-based chemotherapy for patients with advanced non-small cell lung cancer that has spread to other parts o...
What is the current status of trial NCT06216301?
This trial is currently recruiting. It is a Phase 3 study. The enrollment target is 734 participants. The study started on 2024-07-31. Estimated completion is 2028-10.
What conditions does trial NCT06216301 study?
This clinical trial studies the following conditions: Metastatic Non Small Cell Lung Cancer.
What interventions are being tested in trial NCT06216301?
The interventions under investigation include: Pembrolizumab (DRUG), NovoTTF-200T (DEVICE), Platinum based chemotherapy (DRUG).
Who is sponsoring clinical trial NCT06216301?
This trial is sponsored by NovoCure, which has 11 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06216301 being conducted?
This trial has 20 study locations across Alabama, Arizona, California, Florida, Illinois. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Metastatic Non Small Cell Lung Cancer
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT06216301's enrollment target sits among peer trials
734 7th of 31 higher than 25 of 31 other Metastatic Non Small Cell Lung Cancer trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Metastatic Non Small Cell Lung Cancer trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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