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NCT06975293 · ClinicalTrials.gov registry record · Phase 1
STC-15 as a Part of Combination Therapy With Toripalimab in Selected Advanced Cancers
A Phase 1 study of Solid Tumor and Metastatic Melanoma, sponsored by STORM Therapeutics.
- Recruiting
- Registry status
- Phase 1
- Development phase
- 188
- Enrollment target
- 3
- Study locations
NCT06975293: Recruiting Phase 1 study of Solid Tumor and Metastatic Melanoma, sponsored by STORM Therapeutics.
NCT06975293 is a Phase 1 study of Solid Tumor and Metastatic Melanoma that is actively recruiting participants, run by STORM Therapeutics. The registered enrollment target is 188 participants, below the 221-participant average among 196 other Solid Tumor trials with a reported enrollment target (15% lower). The trial reports 3 study locations across 3 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06975293, a Phase 1 study of Solid Tumor and Metastatic Melanoma, is actively recruiting participants, sponsored by STORM Therapeutics.
- RECRUITING
- Registry status
- Phase 1
- Development phase
- 188 participants
- Enrollment target
- 3
- Study locations
Study Summary
This early phase oncology trial will be conducted at various study centers to investigate the safety, tolerability, and antitumor activity of STC-15 (a METTL3 inhibitor) in combination with toripalimab (anti- programmed cell death 1 \[PD-1\]) in four different locally advanced unresectable or metastatic tumors such as indications: (1) in combination with toripalimab (anti- programmed cell death 1 \[PD-1\]) in locally advanced and unresectable or metastatic non-small cell lung cancer (NSCLC), (2) in combination with toripalimab in locally advanced unresectable or metastatic melanoma, (3) in combination with toripalimab in locally advanced unresectable or metastatic endometrial cancers, and (4) in combination with toripalimab in locally advanced or metastatic head and neck squamous cell carcinoma (HNSCC). This study comprises of 2 parts: a combination dose escalation part (Phase 1b) followed by an assessment of the combination treatment's antitumor activity (Phase 2). This study will be conducted in adult participants with advanced malignancies to characterize the safety, tolerability, PK, and clinical activity of STC-15 in combination with toripalimab.
Primary Outcome
Incidence of adverse events graded according to CTCAE v5.0
Conditions Studied
Interventions
- COMBINATION_PRODUCT STC-15 in combination with toripalimab
Study Locations (3)
New York
- Northwell Health Cancer Institute - Lake Success
Texas
- The START Center - San Antonio
Virginia
- NEXT Oncology - Fairfax
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 188 participants |
| Start Date | 2025-05-05 |
| Est. Completion | 2027-06-29 |
| Phase | Phase 1 |
What NCT06975293 shows while recruiting
NCT06975293 is an interventional study that assigns participants to a tested intervention. The registered 188 participants enrollment target is mid-sized for trials with a published cap, below the 221-participant average among 196 other Solid Tumor trials with a reported enrollment target (15% lower).
The record links to 5 conditions, with Solid Tumor appearing as the primary indexed condition, and to 1 intervention - of which STC-15 in combination with toripalimab is the first listed.
NCT06975293 reports a single indexed study location in New York, Texas, Virginia.
Frequently Asked Questions
What is clinical trial NCT06975293 about?
NCT06975293 is a clinical study titled "STC-15 as a Part of Combination Therapy With Toripalimab in Selected Advanced Cancers". This early phase oncology trial will be conducted at various study centers to investigate the safety, tolerability, and antitumor activity of STC-15 (a METTL3 inhibitor) in combination with toripalimab (anti- programmed cell death 1 \[PD-1\]) in four different locally advanced unresectable or metast...
What is the current status of trial NCT06975293?
This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 188 participants. The study started on 2025-05-05. Estimated completion is 2027-06-29.
What conditions does trial NCT06975293 study?
This clinical trial studies the following conditions: Solid Tumor, Metastatic Melanoma, Metastatic Non Small Cell Lung Cancer, Metastatic Head-and-neck Squamous-cell Carcinoma, Metastatic Endometrial Cancer.
What interventions are being tested in trial NCT06975293?
The interventions under investigation include: STC-15 in combination with toripalimab (COMBINATION_PRODUCT).
Who is sponsoring clinical trial NCT06975293?
This trial is sponsored by STORM Therapeutics, which has 2 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06975293 being conducted?
This trial has 3 study locations across New York, Texas, Virginia. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Solid Tumor
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT06975293's enrollment target sits among peer trials
188 44th of 196 higher than 153 of 196 other Solid Tumor trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Solid Tumor trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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