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RECRUITING Phase 1

STC-15 as a Part of Combination Therapy With Toripalimab in Selected Advanced Cancers

NCT06975293 · View on ClinicalTrials.gov ↗

Study Summary

This early phase oncology trial will be conducted at various study centers to investigate the safety, tolerability, and antitumor activity of STC-15 (a METTL3 inhibitor) in combination with toripalimab (anti- programmed cell death 1 \[PD-1\]) in four different locally advanced unresectable or metastatic tumors such as indications: (1) in combination with toripalimab (anti- programmed cell death 1 \[PD-1\]) in locally advanced and unresectable or metastatic non-small cell lung cancer (NSCLC), (2) in combination with toripalimab in locally advanced unresectable or metastatic melanoma, (3) in combination with toripalimab in locally advanced unresectable or metastatic endometrial cancers, and (4) in combination with toripalimab in locally advanced or metastatic head and neck squamous cell carcinoma (HNSCC). This study comprises of 2 parts: a combination dose escalation part (Phase 1b) followed by an assessment of the combination treatment's antitumor activity (Phase 2). This study will be conducted in adult participants with advanced malignancies to characterize the safety, tolerability, PK, and clinical activity of STC-15 in combination with toripalimab.

Interventions

  • COMBINATION_PRODUCT STC-15 in combination with toripalimab

Study Locations (3)

New York

  • Northwell Health Cancer Institute — Lake Success

Texas

  • The START Center — San Antonio

Virginia

  • NEXT Oncology — Fairfax

Trial Details

FieldValue
Enrollment Target 188 participants
Start Date 2025-05-05
Est. Completion 2027-06-29
Phase Phase 1

Sponsor

STORM Therapeutics

2 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT06975293

The ClinicalTrials.gov registry entry for NCT06975293 describes a study currently listed as recruiting. It is categorized as Phase 1, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 188 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is STORM Therapeutics, which has 2 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 5 conditions, with Solid Tumor appearing as the primary indexed condition, and to 1 intervention — of which STC-15 in combination with toripalimab is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT06975293 reports 3 study locations spanning 3 distinct geographic areas — top geographies include New York, Texas, Virginia. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT06975293 about?

NCT06975293 is a clinical study titled "STC-15 as a Part of Combination Therapy With Toripalimab in Selected Advanced Cancers". This early phase oncology trial will be conducted at various study centers to investigate the safety, tolerability, and antitumor activity of STC-15 (a METTL3 inhibitor) in combination with toripalimab (anti- programmed cell death 1 \[PD-1\]) in four different locally advanced unresectable or metast...

What is the current status of trial NCT06975293?

This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 188 participants. The study started on 2025-05-05. Estimated completion is 2027-06-29.

What conditions does trial NCT06975293 study?

This clinical trial studies the following conditions: Solid Tumor, Metastatic Melanoma, Metastatic Non-small Cell Lung Cancer, Metastatic Head-and-neck Squamous-cell Carcinoma, Metastatic Endometrial Cancer. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT06975293?

The interventions under investigation include: STC-15 in combination with toripalimab (COMBINATION_PRODUCT). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT06975293?

This trial is sponsored by STORM Therapeutics, which has 2 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT06975293 being conducted?

This trial has 3 study locations across New York, Texas, Virginia. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial