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ClinicalTrials.gov 28 recruiting now official registry

Metabolic Syndrome clinical trials

28 of 104 indexed Metabolic Syndrome trials are currently recruiting.

104 US clinical trials · 28 currently recruiting

Metabolic Syndrome is the subject of 104 registered US clinical trials on ClinicalTrials.gov, 28 of them currently open to new participants. 7 are in Phase 3-4 (later-stage) and 9 in Phase 1-2 (earlier-stage). The most active sponsor is University of California, Davis, running 5 of these trials.

The research picture

Metabolic Syndrome has 104 registered US clinical trials, 28 of them open to new participants right now, about 27% of the total.

28
recruiting participants now
27%
of trials open to enrollment
7
in Phase 3–4 (later-stage)
5
top sponsor: University of California, Davis
Phase 13Phase 26Phase 31Phase 46

Active & Recent Trials

104 total, page 2 of 3

COMPLETED Phase 3 254 participants

VIsceral Fat Reduction Assessed by CT-scan On RImonabAnt

Sanofi

NCT00299325

COMPLETED NA 240 participants

A Simple Dietary Message to Improve Dietary Quality for Metabolic Syndrome

University of Massachusetts, Worcester

NCT00911885

COMPLETED 225 participants

A Study of the Function of Hormones Present In Taste Buds

National Institute on Aging (NIA)

NCT00233298

COMPLETED NA 182 participants

A Web-based Approach to Treating Cardiovascular Disease Risk in Employees With Metabolic Syndrome

Baptist Health South Florida

NCT01912209

COMPLETED 146 participants

Chronic Inflammation and Exercise Responsiveness

Mayo Clinic

NCT02732509

COMPLETED Phase 2 125 participants

Metformin in Kidney Disease

VA Office of Research and Development

NCT02252081

COMPLETED NA 125 participants

Canola Oil Multi-Centre Intervention Trial II

University of Manitoba

NCT02029833

COMPLETED 110 participants

Assessing Virologic Success and Metabolic Changes in Patients Switching From a TDF to TAF Containing Antiretroviral Therapy Regimen

Thomas Jefferson University

NCT03646370

COMPLETED 104 participants

The Role of Leptin Receptors in NASH

University of California, Davis

NCT00583999

COMPLETED NA 97 participants

Metabolic Syndrome in PCOS: Precursors and Interventions

Northwestern University

NCT00442689

COMPLETED 90 participants

Taste Perception and Chronic Disease Risk

Tufts University

NCT01023906

COMPLETED NA 80 participants

Improving Metabolic Health in Patients With Diastolic Dysfunction

University of Texas Southwestern Medical Center

NCT03448185

COMPLETED NA 75 participants

Nutrition Outreach and Understanding: Research In Serving Hearts Through Healthy Eating And Tailored Support

Amanda Shallcross

NCT06460272

COMPLETED NA 72 participants

The Impact of Low-fat and Full-fat Dairy Consumption on Glucose Homeostasis (DAIRY Study)

Fred Hutchinson Cancer Center

NCT02663544

COMPLETED Phase 4 60 participants

A Comparison of the Effect of Olmesartan Medoxomil, Losartan Potassium, and Atenolol on the Ability of Overweight Patients With High Blood Pressure to Respond to Insulin

Daiichi Sankyo

NCT00185094

COMPLETED NA 60 participants

Soybean Oil Trial of cArdiovascular Risk

USDA Beltsville Human Nutrition Research Center

NCT02404207

COMPLETED NA 58 participants

Effect of Resvida, a Comparison With Calorie Restriction Regimen

Washington University School of Medicine

NCT00823381

COMPLETED NA 55 participants

Healthy Liver - Healthy Brain

University of Texas at Austin

NCT05216796

COMPLETED NA 54 participants

Grains Reduce Adiposity and Improve Nutrition Study

Penn State University

NCT00924521

COMPLETED Phase 2 50 participants

The Health-Promoting Role of Pears in Men and Women With Metabolic Syndrome

Florida State University

NCT02228837

COMPLETED Phase 1 50 participants

Cardiac Autonomic Neuropathy in Patients With Metabolic Syndrome

University of Michigan

NCT00907127

COMPLETED Phase 4 46 participants

Comparative Effects of Chronic Treatment With Olanzapine and Risperidone on Glucose and Lipid Metabolism

Nathan Kline Institute for Psychiatric Research

NCT00287820

COMPLETED NA 46 participants

Gut-level Antiinflammatory Activities of Green Tea in Metabolic Syndrome

Ohio State University

NCT03973996

COMPLETED NA 44 participants

P20 Extending Sleep to Reverse Metabolic Syndrome

NYU Langone Health

NCT03596983

COMPLETED NA 42 participants

Fetuin-A Phosphorylation Status in Insulin Resistance and Metabolic Syndrome

Auburn University

NCT03478046

COMPLETED NA 40 participants

Developing an Adaptive Lifestyle Intervention Program in Family Medicine Clinics

University of Alabama at Birmingham

NCT04392284

COMPLETED NA 40 participants

The Metabolic Effects of Short-term Walnut Consumption in Subjects With the Metabolic Syndrome

Christos Mantzoros

NCT00525629

COMPLETED NA 37 participants

Short-term Sugary Beverage Consumption on Glucose Control and Cardiovascular Disease Risk Factors

Kansas State University

NCT04118257

COMPLETED NA 36 participants

12 Weeks of Resistance Band Exercise Impacts on Metabolic Syndrome Progression in Postmenopausal Women

Pusan National University

NCT04014686

COMPLETED NA 36 participants

Bioactive Plant Foods: Effects on Functional Bioavailability and Genomic Stability

Tufts University

NCT00963118

COMPLETED NA 33 participants

Effects of Fish Oils on Inflammation and Insulin Resistance

Philip Kern

NCT00579436

COMPLETED NA 32 participants

Effects of Consuming Sugar-Sweetened Beverages With Meals for 10 Weeks

University of California, Davis

NCT01165853

COMPLETED 30 participants

The Incidence and Treatment of Insulin Resistance Among Men With Erectile Dysfunction

Milton S. Hershey Medical Center

NCT00284960

COMPLETED NA 28 participants

Resveratrol and the Metabolic Syndrome

Rockefeller University

NCT01714102

COMPLETED NA 28 participants

The BANGALORE Study; Combination of Berberine, Lipoic Acid, and Picrorhiza

Carmel Biosciences

NCT01696448

COMPLETED NA 26 participants

Spinal Cord Injury Exercise and Nutrition Conceptual Engagement

University of Miami

NCT03495986

COMPLETED NA 26 participants

Women's Lifestyle Balance Study

University of California, San Francisco

NCT03184337

COMPLETED NA 25 participants

Impact of 60 Days Powdered Tart Cherry Supplementation on Metabolic Syndrome

Ohio University

NCT05614947

COMPLETED NA 24 participants

Sleep Chatbot Intervention for Emerging Black/African American Adults

University of Delaware

NCT05956886

COMPLETED NA 24 participants

Role of Eicosapentaenoic Acid (EPA) and Docosahexaenoic Acid (DHA) on Inflammation and Lipids

Tufts University

NCT02670382

COMPLETED NA 23 participants

Impact of a Ketogenic Diet on Metabolic and Psychiatric Health in Patients With Bipolar or Schizophrenia Illness

Stanford University

NCT03935854

COMPLETED NA 21 participants

Vasoprotective Activities of Low-Fat Milk in Individuals With Metabolic Syndrome

University of Connecticut

NCT01411293

COMPLETED NA 21 participants

Exercise-Induced Epigenetic Modifications in Obese Aging Women

University of Georgia

NCT01977885

COMPLETED NA 20 participants

Effect of Diet-induced Weight Loss on HIV-associated Metabolic Syndrome

Washington University School of Medicine

NCT00857298

COMPLETED NA 20 participants

Effects of Diet Interventions on Monocytes in Metabolic Syndrome

Baylor College of Medicine

NCT03591588

COMPLETED NA 20 participants

Effect of Vestibular Stimulation on Fat Consumption and Energy Expenditure as Assessed Using Indirect Calorimetry

University of California, San Diego

NCT03138382

COMPLETED NA 19 participants

Metabolic Effects of Pulse Consumption on Biomarkers in Adults With Type 2 Diabetes or Met Syn

Iowa State University

NCT05145998

COMPLETED 18 participants

Impact of Metabolic Flexibility on Changes in Metabolic Health

Pennington Biomedical Research Center

NCT06340321

COMPLETED NA 16 participants

Virtual Teaching Kitchen

Boston University

NCT04509206

COMPLETED NA 12 participants

The Effect of Whole Beans on Inflammation and Satiety

University of California, Davis

NCT01190384

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Phase Distribution

PhaseTrial count
Phase 1 3
Phase 2 6
Phase 3 1
Phase 4 6

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Metabolic Syndrome Trial Landscape

104 indexed Metabolic Syndrome studies · 28 recruiting (27%).

Phase mix: 7 late (III/IV) vs 9 early (I/II).

Top sponsor: University of California, Davis (5 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Metabolic Syndrome?

PlainTrial tracks 104 US clinical trials for Metabolic Syndrome, of which 28 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Metabolic Syndrome?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.