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Metabolic Syndrome clinical trials
28 of 104 indexed Metabolic Syndrome trials are currently recruiting.
104 US clinical trials · 28 currently recruiting
Metabolic Syndrome is the subject of 104 registered US clinical trials on ClinicalTrials.gov, 28 of them currently open to new participants. 7 are in Phase 3-4 (later-stage) and 9 in Phase 1-2 (earlier-stage). The most active sponsor is University of California, Davis, running 5 of these trials.
The research picture
Metabolic Syndrome has 104 registered US clinical trials, 28 of them open to new participants right now, about 27% of the total.
- 28
- recruiting participants now
- 27%
- of trials open to enrollment
- 7
- in Phase 3–4 (later-stage)
- 5
- top sponsor: University of California, Davis
Active & Recent Trials
104 total, page 2 of 3
VIsceral Fat Reduction Assessed by CT-scan On RImonabAnt
Sanofi
NCT00299325
A Simple Dietary Message to Improve Dietary Quality for Metabolic Syndrome
University of Massachusetts, Worcester
NCT00911885
A Study of the Function of Hormones Present In Taste Buds
National Institute on Aging (NIA)
NCT00233298
A Web-based Approach to Treating Cardiovascular Disease Risk in Employees With Metabolic Syndrome
Baptist Health South Florida
NCT01912209
Chronic Inflammation and Exercise Responsiveness
Mayo Clinic
NCT02732509
Metformin in Kidney Disease
VA Office of Research and Development
NCT02252081
Canola Oil Multi-Centre Intervention Trial II
University of Manitoba
NCT02029833
Assessing Virologic Success and Metabolic Changes in Patients Switching From a TDF to TAF Containing Antiretroviral Therapy Regimen
Thomas Jefferson University
NCT03646370
The Role of Leptin Receptors in NASH
University of California, Davis
NCT00583999
Metabolic Syndrome in PCOS: Precursors and Interventions
Northwestern University
NCT00442689
Taste Perception and Chronic Disease Risk
Tufts University
NCT01023906
Improving Metabolic Health in Patients With Diastolic Dysfunction
University of Texas Southwestern Medical Center
NCT03448185
Nutrition Outreach and Understanding: Research In Serving Hearts Through Healthy Eating And Tailored Support
Amanda Shallcross
NCT06460272
The Impact of Low-fat and Full-fat Dairy Consumption on Glucose Homeostasis (DAIRY Study)
Fred Hutchinson Cancer Center
NCT02663544
A Comparison of the Effect of Olmesartan Medoxomil, Losartan Potassium, and Atenolol on the Ability of Overweight Patients With High Blood Pressure to Respond to Insulin
Daiichi Sankyo
NCT00185094
Soybean Oil Trial of cArdiovascular Risk
USDA Beltsville Human Nutrition Research Center
NCT02404207
Effect of Resvida, a Comparison With Calorie Restriction Regimen
Washington University School of Medicine
NCT00823381
Healthy Liver - Healthy Brain
University of Texas at Austin
NCT05216796
Grains Reduce Adiposity and Improve Nutrition Study
Penn State University
NCT00924521
The Health-Promoting Role of Pears in Men and Women With Metabolic Syndrome
Florida State University
NCT02228837
Cardiac Autonomic Neuropathy in Patients With Metabolic Syndrome
University of Michigan
NCT00907127
Comparative Effects of Chronic Treatment With Olanzapine and Risperidone on Glucose and Lipid Metabolism
Nathan Kline Institute for Psychiatric Research
NCT00287820
Gut-level Antiinflammatory Activities of Green Tea in Metabolic Syndrome
Ohio State University
NCT03973996
P20 Extending Sleep to Reverse Metabolic Syndrome
NYU Langone Health
NCT03596983
Fetuin-A Phosphorylation Status in Insulin Resistance and Metabolic Syndrome
Auburn University
NCT03478046
Developing an Adaptive Lifestyle Intervention Program in Family Medicine Clinics
University of Alabama at Birmingham
NCT04392284
The Metabolic Effects of Short-term Walnut Consumption in Subjects With the Metabolic Syndrome
Christos Mantzoros
NCT00525629
Short-term Sugary Beverage Consumption on Glucose Control and Cardiovascular Disease Risk Factors
Kansas State University
NCT04118257
12 Weeks of Resistance Band Exercise Impacts on Metabolic Syndrome Progression in Postmenopausal Women
Pusan National University
NCT04014686
Bioactive Plant Foods: Effects on Functional Bioavailability and Genomic Stability
Tufts University
NCT00963118
Effects of Fish Oils on Inflammation and Insulin Resistance
Philip Kern
NCT00579436
Effects of Consuming Sugar-Sweetened Beverages With Meals for 10 Weeks
University of California, Davis
NCT01165853
The Incidence and Treatment of Insulin Resistance Among Men With Erectile Dysfunction
Milton S. Hershey Medical Center
NCT00284960
Resveratrol and the Metabolic Syndrome
Rockefeller University
NCT01714102
The BANGALORE Study; Combination of Berberine, Lipoic Acid, and Picrorhiza
Carmel Biosciences
NCT01696448
Spinal Cord Injury Exercise and Nutrition Conceptual Engagement
University of Miami
NCT03495986
Women's Lifestyle Balance Study
University of California, San Francisco
NCT03184337
Impact of 60 Days Powdered Tart Cherry Supplementation on Metabolic Syndrome
Ohio University
NCT05614947
Sleep Chatbot Intervention for Emerging Black/African American Adults
University of Delaware
NCT05956886
Role of Eicosapentaenoic Acid (EPA) and Docosahexaenoic Acid (DHA) on Inflammation and Lipids
Tufts University
NCT02670382
Impact of a Ketogenic Diet on Metabolic and Psychiatric Health in Patients With Bipolar or Schizophrenia Illness
Stanford University
NCT03935854
Vasoprotective Activities of Low-Fat Milk in Individuals With Metabolic Syndrome
University of Connecticut
NCT01411293
Exercise-Induced Epigenetic Modifications in Obese Aging Women
University of Georgia
NCT01977885
Effect of Diet-induced Weight Loss on HIV-associated Metabolic Syndrome
Washington University School of Medicine
NCT00857298
Effects of Diet Interventions on Monocytes in Metabolic Syndrome
Baylor College of Medicine
NCT03591588
Effect of Vestibular Stimulation on Fat Consumption and Energy Expenditure as Assessed Using Indirect Calorimetry
University of California, San Diego
NCT03138382
Metabolic Effects of Pulse Consumption on Biomarkers in Adults With Type 2 Diabetes or Met Syn
Iowa State University
NCT05145998
Impact of Metabolic Flexibility on Changes in Metabolic Health
Pennington Biomedical Research Center
NCT06340321
Virtual Teaching Kitchen
Boston University
NCT04509206
The Effect of Whole Beans on Inflammation and Satiety
University of California, Davis
NCT01190384
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 3 |
| Phase 2 | 6 |
| Phase 3 | 1 |
| Phase 4 | 6 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Metabolic Syndrome Trial Landscape
104 indexed Metabolic Syndrome studies · 28 recruiting (27%).
Phase mix: 7 late (III/IV) vs 9 early (I/II).
Top sponsor: University of California, Davis (5 trials), 9 others listed. 50 shown below, recruiting first.
How to read this condition's trial landscape
That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Metabolic Syndrome?
PlainTrial tracks 104 US clinical trials for Metabolic Syndrome, of which 28 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Metabolic Syndrome?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.