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NCT01977885 · ClinicalTrials.gov registry record · NA
Exercise-Induced Epigenetic Modifications in Obese Aging Women
A NA study of Metabolic Syndrome, sponsored by University of Georgia.
- Completed
- Registry status
- NA
- Development phase
- 21
- Enrollment target
- 1
- Study location
NCT01977885: Completed NA study of Metabolic Syndrome, sponsored by University of Georgia.
NCT01977885 is a NA study of Metabolic Syndrome that has completed, run by University of Georgia. The registered enrollment target is 21 participants, below the 1,205-participant average among 102 other Metabolic Syndrome trials with a reported enrollment target (98% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT01977885, a NA study of Metabolic Syndrome, has completed, sponsored by University of Georgia.
- COMPLETED
- Registry status
- NA
- Development phase
- 21 participants
- Enrollment target
- 1
- Study location
Study Summary
Our greatest public health challenge is obesity and the co-morbidities of metabolic syndrome (MetS). Age is an established risk factor for MetS and specific to women, data indicates that the prevalence of MetS increases substantially with the menopausal transition with postmenopausal women having a 60% increased risk of MetS. Menopause also contributes to reductions in strength, physical function and often psychological well-being (e.g. fatigue). Obese individuals also have: a) impaired immune function and chronic inflammatory responses associated with changes in the white blood cell population in blood and fat tissues; and, b) increased secretion of and signaling by proteins in their fat cells. Weight loss, which requires an energy deficit through increased physical activity and/or caloric restriction (EX+CR), reduces risk for MetS in older sedentary obese women by reducing insulin resistance and chronic systemic inflammation. Science and clinical practice will be advanced by examining the molecular mechanisms by which EX+CR affects risk for MetS in older women. The primary aim is to determine if CD4+ T cells will report the differential epigenetic reprogramming of relevant gene expression associated with metabolic indices resulting from EX+CR induced weight loss in older women known to be at risk for MetS. This pilot data will be used to generate an NIH proposal of the same topic. A secondary aim is to assess the impact of weight loss on physical function and psychological well-being which will provide pilot data for an additional grant proposal regarding weight management in postmenopausal women.
Primary Outcome
The primary aim is to determine if CD4+ T cells will report the differential epigenetic reprogramming of relevant gene expression associated with metabolic indices resulting from EX+CR induced weight loss in older women known to be at risk for MetS.
Conditions Studied
Interventions
- BEHAVIORAL Exercise
- BEHAVIORAL High Protein Diet
Study Locations (1)
Georgia
- Body Composition and Metabolism Lab, UGA, Ramsey Student Center - Athens
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 21 participants |
| Start Date | 2013-06 |
| Est. Completion | 2014-12 |
| Phase | NA |
What the finished NCT01977885 record still lists
NCT01977885 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 21 participants, a relatively small participant target, below the 1,205-participant average among 102 other Metabolic Syndrome trials with a reported enrollment target (98% lower).
The record links to 1 condition, with Metabolic Syndrome appearing as the primary indexed condition, and to 2 interventions - of which Exercise is the first listed.
NCT01977885 reports a single indexed study location in Georgia.
Frequently Asked Questions
What is clinical trial NCT01977885 about?
NCT01977885 is a clinical study titled "Exercise-Induced Epigenetic Modifications in Obese Aging Women". Our greatest public health challenge is obesity and the co-morbidities of metabolic syndrome (MetS). Age is an established risk factor for MetS and specific to women, data indicates that the prevalence of MetS increases substantially with the menopausal transition with postmenopausal women having a ...
What is the current status of trial NCT01977885?
This trial is currently completed. It is a NA study. The enrollment target is 21 participants. The study started on 2013-06. Estimated completion is 2014-12.
What conditions does trial NCT01977885 study?
This clinical trial studies the following conditions: Metabolic Syndrome.
What interventions are being tested in trial NCT01977885?
The interventions under investigation include: Exercise (BEHAVIORAL), High Protein Diet (BEHAVIORAL).
Who is sponsoring clinical trial NCT01977885?
This trial is sponsored by University of Georgia, which has 59 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT01977885 being conducted?
This trial has 1 study location across Georgia. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Where NCT01977885's enrollment target sits among peer trials
21 89th of 102 higher than 13 of 102 other Metabolic Syndrome trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Metabolic Syndrome trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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