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Metabolic Syndrome
Open-data reference.
104 US clinical trials · 28 currently recruiting
Active & Recent Trials
Triage Survey for Cardiovascular, Obesity, and Related Endocrine Trial Eligibility
Brooklyn Clinical Research
NCT06412536
A Randomized Comparison of Stage-Based Care Versus Risk Factor-Based Care for Prevention of Cardiovascular Events
Cleerly
NCT06112418
Non-interventional Pre-screening Protocol Aims to Evaluate Participants for Potential Trial Eligibility in Future Clinical Trials/Studies Focusing on Metabolic and Psychiatric Health.
Clindove Research
NCT07106879
Wellness Program Outreach and Effectiveness
Massachusetts Institute of Technology
NCT06725511
Study of the Effect of Innate on the Inflammatory Response to Endotoxin
National Institute of Environmental Health Sciences (NIEHS)
NCT01143480
Fasting Insulin and HOMA-IR by Age, Sex, Race/Ethnicity, BMI, and PCOS Diagnosis
Lilli Health
NCT05950282
Our Voices Matter: Intervention for Depression in Youth
Ann & Robert H Lurie Children's Hospital of Chicago
NCT07216326
Stand Up for Your Health with a Sit-stand Desk
Medical College of Wisconsin
NCT05585190
Time-Restricted Feeding Intervention in Metabolically-Unhealthy Postmenopausal Women
Julie Pendergast
NCT04893226
Impact GLP-1 Agonists Following Bariatric
University of Missouri-Columbia
NCT06132477
Long Term Impact of Time-Restricted Eating on Parameters of Cardiometabolic Health
University of California, San Diego
NCT07189234
Animal and Plant Proteins and Glucose Metabolism
University of Missouri-Columbia
NCT03994367
Combined Oral Contraceptive Pill and Resistance Starch
University of Pennsylvania
NCT06852365
Physical Activity Targeting Metabolic Syndrome for Prevention of Breast Cancer in SAI Women
Rush University Medical Center
NCT06827704
Lifestyle Medicine: Establishing Clinical Approaches to Chronic Disease for Rural Patients
West Virginia School of Osteopathic Medicine
NCT06049420
Effects of Exercise and GLP-1 Agonism on Muscle Microvascular Perfusion and Insulin Action in Adults With Metabolic Syndrome
University of Virginia
NCT04575844
Feasibility of Reducing Cardiovascular Disease Risk Factors in Hispanics Through a Family-Based Community Intervention
Poudre Valley Health System
NCT05322876
The Effect of SGLT2 Inhibition on Adipose Inflammation and Endothelial Function
Vanderbilt University Medical Center
NCT05972564
Metabolic Adaptations to Weight Loss With and Without Exercise
University of Michigan
NCT05806801
Testing the Adipose Expandability Hypothesis in Vivo During Overfeeding
Pennington Biomedical Research Center
NCT04583514
Obesity, Metabolic Dysregulation and the Airway Epithelium in Asthmatics
University of Colorado, Denver
NCT03215836
VR Stimulation of Exercise Response in Sedentary Humans
Wayne State University
NCT07296991
Exercise and Carotid Artery Function in Metabolic Syndrome
University of Wisconsin, Madison
NCT07430839
Exercise Effects on Adipose Tissue Structure and Function
University of Michigan
NCT04812314
Probiotics and Gut Health
Penn State University
NCT03418857
Exercise and Time of Day in Type 2 Diabetes
Rutgers, The State University of New Jersey
NCT05108987
Impact of Supplemental Fiber on Gut and Vascular Health Related in Obesity Phenotypes
Ball State University
NCT07095426
Targeting Metabolic Syndrome From the Emergency Department Through Mixed-Methods: Pilot Trial
Indiana University
NCT07119658
Use of Continuous Glucose Monitoring in Non-Diabetic Population to Compliment Signos Mobile Health Platform
Signos
NCT05121844
Signos DM2 Empowerment Study (SIGNOS-CGM-EMPOWER-201-2022)
Signos
NCT05874635
The PIVOT Trial: Project on EHR-Integrated Lifestyle Interventions for Adults Aged Fifty and Older
University of Illinois at Chicago
NCT05654142
Northern Manhattan Study of Metabolism and Mind
Columbia University
NCT02470260
Using Signos mHealth Platform in Adults for Weight Management
Signos
NCT06214221
FIT Families Multicomponent Obesity Intervention for African American Adolescents
Medical University of South Carolina
NCT04974554
Role of Immune System in Obesity-related Inflammation and Cardiometabolic Risk
Washington University School of Medicine
NCT01104220
Diet and Health in Adults With Metabolic Syndrome
University of Arkansas, Fayetteville
NCT03935048
Causal Mechanisms in Adolescent Arterial Stiffness
Baylor College of Medicine
NCT04128969
Almonds to Improve Gut Health and Decrease Inflammation
Oregon State University
NCT05790564
Healthy Lifestyles: A Home Based Physical Activity Intervention in Persons Living With HIV
Georgetown University
NCT05896852
Feasibility of the Paso Program for Patients With Metabolic Dysfunction Associated Steatotic Liver Disease
Baylor College of Medicine
NCT06854185
Effects of Pulse Consumption, Gut Microbiome, and Appetite in Healthy Participants
University of Missouri-Columbia
NCT07043712
Determine How Consumption of Dairy Fat Fractions Rich in Phospholipids and Proteins Influence Inflammation in the Fed State-Phase 1
University of California, Davis
NCT01811329
Food is Medicine vs Lifestyle Medicine For Cardiovascular Kidney Metabolic (CKM) Syndrome
Rutgers, The State University of New Jersey
NCT06461273
Understanding Components of Mind-body Exercise for Physical Activity Engagement in Metabolic Syndrome
Beth Israel Deaconess Medical Center
NCT05242640
Plant-based Diet for Kidney Transplant Recipients
George Washington University
NCT06186843
Determine How Consumption of Dairy Fat as Cheese Influences Inflammation-Phase 2
University of California, Davis
NCT01803633
Evaluating the Navajo Community Outreach and Patient Empowerment (COPE) Program
Brigham and Women's Hospital
NCT03326206
Effects of Infant Egg Consumption on Child Health and Cognition Development
State University of New York at Buffalo
NCT04345185
Association of Genes to Resistance to Weight Loss in Obese Patients
Interleukin Genetics
NCT00858221
Slowing HEART diSease With Lifestyle and Omega-3 Fatty Acids
Beth Israel Deaconess Medical Center
NCT01624727
VIsceral Fat Reduction Assessed by CT-scan On RImonabAnt
Sanofi
NCT00299325
A Simple Dietary Message to Improve Dietary Quality for Metabolic Syndrome
University of Massachusetts, Worcester
NCT00911885
A Study of the Function of Hormones Present In Taste Buds
National Institute on Aging (NIA)
NCT00233298
A Web-based Approach to Treating Cardiovascular Disease Risk in Employees With Metabolic Syndrome
Baptist Health South Florida
NCT01912209
Chronic Inflammation and Exercise Responsiveness
Mayo Clinic
NCT02732509
Metformin in Kidney Disease
VA Office of Research and Development
NCT02252081
Canola Oil Multi-Centre Intervention Trial II
University of Manitoba
NCT02029833
Assessing Virologic Success and Metabolic Changes in Patients Switching From a TDF to TAF Containing Antiretroviral Therapy Regimen
Thomas Jefferson University
NCT03646370
The Role of Leptin Receptors in NASH
University of California, Davis
NCT00583999
Metabolic Syndrome in PCOS: Precursors and Interventions
Northwestern University
NCT00442689
Taste Perception and Chronic Disease Risk
Tufts University
NCT01023906
Improving Metabolic Health in Patients With Diastolic Dysfunction
University of Texas Southwestern Medical Center
NCT03448185
Nutrition Outreach and Understanding: Research In Serving Hearts Through Healthy Eating And Tailored Support
Amanda Shallcross
NCT06460272
The Impact of Low-fat and Full-fat Dairy Consumption on Glucose Homeostasis (DAIRY Study)
Fred Hutchinson Cancer Center
NCT02663544
A Comparison of the Effect of Olmesartan Medoxomil, Losartan Potassium, and Atenolol on the Ability of Overweight Patients With High Blood Pressure to Respond to Insulin
Daiichi Sankyo
NCT00185094
Soybean Oil Trial of cArdiovascular Risk
USDA Beltsville Human Nutrition Research Center
NCT02404207
Effect of Resvida, a Comparison With Calorie Restriction Regimen
Washington University School of Medicine
NCT00823381
Healthy Liver - Healthy Brain
University of Texas at Austin
NCT05216796
Grains Reduce Adiposity and Improve Nutrition Study
Penn State University
NCT00924521
The Health-Promoting Role of Pears in Men and Women With Metabolic Syndrome
Florida State University
NCT02228837
Cardiac Autonomic Neuropathy in Patients With Metabolic Syndrome
University of Michigan
NCT00907127
Comparative Effects of Chronic Treatment With Olanzapine and Risperidone on Glucose and Lipid Metabolism
Nathan Kline Institute for Psychiatric Research
NCT00287820
Gut-level Antiinflammatory Activities of Green Tea in Metabolic Syndrome
Ohio State University
NCT03973996
P20 Extending Sleep to Reverse Metabolic Syndrome
NYU Langone Health
NCT03596983
Fetuin-A Phosphorylation Status in Insulin Resistance and Metabolic Syndrome
Auburn University
NCT03478046
Developing an Adaptive Lifestyle Intervention Program in Family Medicine Clinics
University of Alabama at Birmingham
NCT04392284
The Metabolic Effects of Short-term Walnut Consumption in Subjects With the Metabolic Syndrome
Christos Mantzoros
NCT00525629
Short-term Sugary Beverage Consumption on Glucose Control and Cardiovascular Disease Risk Factors
Kansas State University
NCT04118257
12 Weeks of Resistance Band Exercise Impacts on Metabolic Syndrome Progression in Postmenopausal Women
Pusan National University
NCT04014686
Bioactive Plant Foods: Effects on Functional Bioavailability and Genomic Stability
Tufts University
NCT00963118
Effects of Fish Oils on Inflammation and Insulin Resistance
Philip Kern
NCT00579436
Effects of Consuming Sugar-Sweetened Beverages With Meals for 10 Weeks
University of California, Davis
NCT01165853
The Incidence and Treatment of Insulin Resistance Among Men With Erectile Dysfunction
Milton S. Hershey Medical Center
NCT00284960
Resveratrol and the Metabolic Syndrome
Rockefeller University
NCT01714102
The BANGALORE Study; Combination of Berberine, Lipoic Acid, and Picrorhiza
Carmel Biosciences
NCT01696448
Spinal Cord Injury Exercise and Nutrition Conceptual Engagement
University of Miami
NCT03495986
Women's Lifestyle Balance Study
University of California, San Francis
NCT03184337
Impact of 60 Days Powdered Tart Cherry Supplementation on Metabolic Syndrome
Ohio University
NCT05614947
Sleep Chatbot Intervention for Emerging Black/African American Adults
University of Delaware
NCT05956886
Role of Eicosapentaenoic Acid (EPA) and Docosahexaenoic Acid (DHA) on Inflammation and Lipids
Tufts University
NCT02670382
Impact of a Ketogenic Diet on Metabolic and Psychiatric Health in Patients With Bipolar or Schizophrenia Illness
Stanford University
NCT03935854
Vasoprotective Activities of Low-Fat Milk in Individuals With Metabolic Syndrome
University of Connecticut
NCT01411293
Exercise-Induced Epigenetic Modifications in Obese Aging Women
University of Georgia
NCT01977885
Effect of Diet-induced Weight Loss on HIV-associated Metabolic Syndrome
Washington University School of Medicine
NCT00857298
Effects of Diet Interventions on Monocytes in Metabolic Syndrome
Baylor College of Medicine
NCT03591588
Effect of Vestibular Stimulation on Fat Consumption and Energy Expenditure as Assessed Using Indirect Calorimetry
University of California, San Diego
NCT03138382
Metabolic Effects of Pulse Consumption on Biomarkers in Adults With Type 2 Diabetes or Met Syn
Iowa State University
NCT05145998
Impact of Metabolic Flexibility on Changes in Metabolic Health
Pennington Biomedical Research Center
NCT06340321
Virtual Teaching Kitchen
Boston University
NCT04509206
The Effect of Whole Beans on Inflammation and Satiety
University of California, Davis
NCT01190384
Phase Distribution
| Phase | Trial count |
|---|---|
| Early Phase 1 | 3 |
| Phase 2 | 6 |
| Phase 3 | 1 |
| Phase 4 | 6 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Metabolic Syndrome Trial Landscape
ClinicalTrials.gov lists 104 US studies indexed under Metabolic Syndrome, and 28 of those are currently open to recruitment — roughly 27% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
The phase distribution for Metabolic Syndrome shows 7 late-stage studies (Phase 3 and Phase 4 combined) alongside 9 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
Top sponsor activity for Metabolic Syndrome is led by University of California, Davis with 5 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 100 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Metabolic Syndrome?
PlainTrial tracks 104 US clinical trials for Metabolic Syndrome, of which 28 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Metabolic Syndrome?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology — how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2024 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.