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ClinicalTrials.gov 28 recruiting now official registry

Metabolic Syndrome clinical trials

28 of 104 indexed Metabolic Syndrome trials are currently recruiting.

104 US clinical trials · 28 currently recruiting

Metabolic Syndrome is the subject of 104 registered US clinical trials on ClinicalTrials.gov, 28 of them currently open to new participants. 7 are in Phase 3-4 (later-stage) and 9 in Phase 1-2 (earlier-stage). The most active sponsor is University of California, Davis, running 5 of these trials.

The research picture

Metabolic Syndrome has 104 registered US clinical trials, 28 of them open to new participants right now, about 27% of the total.

28
recruiting participants now
27%
of trials open to enrollment
7
in Phase 3–4 (later-stage)
5
top sponsor: University of California, Davis
Phase 13Phase 26Phase 31Phase 46

Active & Recent Trials

104 total, page 1 of 3

RECRUITING 10,000 participants

Triage Survey for Cardiovascular, Obesity, and Related Endocrine Trial Eligibility

Brooklyn Clinical Research

NCT06412536

RECRUITING NA 7,500 participants

A Randomized Comparison of Stage-Based Care Versus Risk Factor-Based Care for Prevention of Cardiovascular Events

Cleerly

NCT06112418

RECRUITING 7,000 participants

Non-interventional Pre-screening Protocol Aims to Evaluate Participants for Potential Trial Eligibility in Future Clinical Trials/Studies Focusing on Metabolic and Psychiatric Health.

Clindove Research

NCT07106879

RECRUITING NA 2,000 participants

Wellness Program Outreach and Effectiveness

Massachusetts Institute of Technology

NCT06725511

RECRUITING 725 participants

Study of the Effect of Innate on the Inflammatory Response to Endotoxin

National Institute of Environmental Health Sciences (NIEHS)

NCT01143480

RECRUITING 500 participants

Fasting Insulin and HOMA-IR by Age, Sex, Race/Ethnicity, BMI, and PCOS Diagnosis

Lilli Health

NCT05950282

RECRUITING NA 300 participants

Our Voices Matter: Intervention for Depression in Youth

Ann & Robert H Lurie Children's Hospital of Chicago

NCT07216326

RECRUITING NA 198 participants

Stand Up for Your Health with a Sit-stand Desk

Medical College of Wisconsin

NCT05585190

RECRUITING NA 164 participants

Time-Restricted Feeding Intervention in Metabolically-Unhealthy Postmenopausal Women

Julie Pendergast

NCT04893226

RECRUITING Phase 4 150 participants

Impact GLP-1 Agonists Following Bariatric

University of Missouri-Columbia

NCT06132477

RECRUITING Phase 2 140 participants

Long Term Impact of Time-Restricted Eating on Parameters of Cardiometabolic Health

University of California, San Diego

NCT07189234

RECRUITING NA 100 participants

Animal and Plant Proteins and Glucose Metabolism

University of Missouri-Columbia

NCT03994367

RECRUITING Phase 2 100 participants

Combined Oral Contraceptive Pill and Resistance Starch

University of Pennsylvania

NCT06852365

RECRUITING NA 96 participants

Physical Activity Targeting Metabolic Syndrome for Prevention of Breast Cancer in SAI Women

Rush University Medical Center

NCT06827704

RECRUITING NA 95 participants

Lifestyle Medicine: Establishing Clinical Approaches to Chronic Disease for Rural Patients

West Virginia School of Osteopathic Medicine

NCT06049420

RECRUITING Phase 4 80 participants

Effects of Exercise and GLP-1 Agonism on Muscle Microvascular Perfusion and Insulin Action in Adults With Metabolic Syndrome

University of Virginia

NCT04575844

RECRUITING NA 80 participants

Feasibility of Reducing Cardiovascular Disease Risk Factors in Hispanics Through a Family-Based Community Intervention

Poudre Valley Health System

NCT05322876

RECRUITING Phase 1 74 participants

The Effect of SGLT2 Inhibition on Adipose Inflammation and Endothelial Function

Vanderbilt University Medical Center

NCT05972564

RECRUITING NA 68 participants

Metabolic Adaptations to Weight Loss With and Without Exercise

University of Michigan

NCT05806801

RECRUITING NA 58 participants

Testing the Adipose Expandability Hypothesis in Vivo During Overfeeding

Pennington Biomedical Research Center

NCT04583514

RECRUITING NA 50 participants

Obesity, Metabolic Dysregulation and the Airway Epithelium in Asthmatics

University of Colorado, Denver

NCT03215836

RECRUITING NA 48 participants

VR Stimulation of Exercise Response in Sedentary Humans

Wayne State University

NCT07296991

RECRUITING 48 participants

Exercise and Carotid Artery Function in Metabolic Syndrome

University of Wisconsin, Madison

NCT07430839

RECRUITING NA 46 participants

Exercise Effects on Adipose Tissue Structure and Function

University of Michigan

NCT04812314

RECRUITING Phase 1 40 participants

Probiotics and Gut Health

Penn State University

NCT03418857

RECRUITING NA 30 participants

Exercise and Time of Day in Type 2 Diabetes

Rutgers, The State University of New Jersey

NCT05108987

RECRUITING NA 20 participants

Impact of Supplemental Fiber on Gut and Vascular Health Related in Obesity Phenotypes

Ball State University

NCT07095426

RECRUITING NA 20 participants

Targeting Metabolic Syndrome From the Emergency Department Through Mixed-Methods: Pilot Trial

Indiana University

NCT07119658

ACTIVE NOT RECRUITING NA 31,187 participants

Use of Continuous Glucose Monitoring in Non-Diabetic Population to Compliment Signos Mobile Health Platform

Signos

NCT05121844

ACTIVE NOT RECRUITING NA 20,000 participants

Signos DM2 Empowerment Study (SIGNOS-CGM-EMPOWER-201-2022)

Signos

NCT05874635

ACTIVE NOT RECRUITING NA 1,029 participants

The PIVOT Trial: Project on EHR-Integrated Lifestyle Interventions for Adults Aged Fifty and Older

University of Illinois at Chicago

NCT05654142

ACTIVE NOT RECRUITING 1,000 participants

Northern Manhattan Study of Metabolism and Mind

Columbia University

NCT02470260

ACTIVE NOT RECRUITING NA 380 participants

Using Signos mHealth Platform in Adults for Weight Management

Signos

NCT06214221

ACTIVE NOT RECRUITING NA 360 participants

FIT Families Multicomponent Obesity Intervention for African American Adolescents

Medical University of South Carolina

NCT04974554

ACTIVE NOT RECRUITING NA 144 participants

Role of Immune System in Obesity-related Inflammation and Cardiometabolic Risk

Washington University School of Medicine

NCT01104220

ACTIVE NOT RECRUITING NA 90 participants

Diet and Health in Adults With Metabolic Syndrome

University of Arkansas, Fayetteville

NCT03935048

ACTIVE NOT RECRUITING Phase 2 90 participants

Causal Mechanisms in Adolescent Arterial Stiffness

Baylor College of Medicine

NCT04128969

ACTIVE NOT RECRUITING NA 80 participants

Almonds to Improve Gut Health and Decrease Inflammation

Oregon State University

NCT05790564

ACTIVE NOT RECRUITING NA 50 participants

Healthy Lifestyles: A Home Based Physical Activity Intervention in Persons Living With HIV

Georgetown University

NCT05896852

ACTIVE NOT RECRUITING NA 50 participants

Feasibility of the Paso Program for Patients With Metabolic Dysfunction Associated Steatotic Liver Disease

Baylor College of Medicine

NCT06854185

ACTIVE NOT RECRUITING NA 44 participants

Effects of Pulse Consumption, Gut Microbiome, and Appetite in Healthy Participants

University of Missouri-Columbia

NCT07043712

ACTIVE NOT RECRUITING NA 38 participants

Determine How Consumption of Dairy Fat Fractions Rich in Phospholipids and Proteins Influence Inflammation in the Fed State-Phase 1

University of California, Davis

NCT01811329

ACTIVE NOT RECRUITING NA 37 participants

Food is Medicine vs Lifestyle Medicine For Cardiovascular Kidney Metabolic (CKM) Syndrome

Rutgers, The State University of New Jersey

NCT06461273

ACTIVE NOT RECRUITING NA 34 participants

Understanding Components of Mind-body Exercise for Physical Activity Engagement in Metabolic Syndrome

Beth Israel Deaconess Medical Center

NCT05242640

ACTIVE NOT RECRUITING NA 25 participants

Plant-based Diet for Kidney Transplant Recipients

George Washington University

NCT06186843

ACTIVE NOT RECRUITING NA 20 participants

Determine How Consumption of Dairy Fat as Cheese Influences Inflammation-Phase 2

University of California, Davis

NCT01803633

COMPLETED 28,813 participants

Evaluating the Navajo Community Outreach and Patient Empowerment (COPE) Program

Brigham and Women's Hospital

NCT03326206

COMPLETED 5,374 participants

Effects of Infant Egg Consumption on Child Health and Cognition Development

State University of New York at Buffalo

NCT04345185

COMPLETED 824 participants

Association of Genes to Resistance to Weight Loss in Obese Patients

Interleukin Genetics

NCT00858221

COMPLETED NA 338 participants

Slowing HEART diSease With Lifestyle and Omega-3 Fatty Acids

Beth Israel Deaconess Medical Center

NCT01624727

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Phase Distribution

PhaseTrial count
Phase 1 3
Phase 2 6
Phase 3 1
Phase 4 6

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Metabolic Syndrome Trial Landscape

104 indexed Metabolic Syndrome studies · 28 recruiting (27%).

Phase mix: 7 late (III/IV) vs 9 early (I/II).

Top sponsor: University of California, Davis (5 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Metabolic Syndrome?

PlainTrial tracks 104 US clinical trials for Metabolic Syndrome, of which 28 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Metabolic Syndrome?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.