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Metabolic Syndrome clinical trials
28 of 104 indexed Metabolic Syndrome trials are currently recruiting.
104 US clinical trials · 28 currently recruiting
Metabolic Syndrome is the subject of 104 registered US clinical trials on ClinicalTrials.gov, 28 of them currently open to new participants. 7 are in Phase 3-4 (later-stage) and 9 in Phase 1-2 (earlier-stage). The most active sponsor is University of California, Davis, running 5 of these trials.
The research picture
Metabolic Syndrome has 104 registered US clinical trials, 28 of them open to new participants right now, about 27% of the total.
- 28
- recruiting participants now
- 27%
- of trials open to enrollment
- 7
- in Phase 3–4 (later-stage)
- 5
- top sponsor: University of California, Davis
Active & Recent Trials
104 total, page 1 of 3
Triage Survey for Cardiovascular, Obesity, and Related Endocrine Trial Eligibility
Brooklyn Clinical Research
NCT06412536
A Randomized Comparison of Stage-Based Care Versus Risk Factor-Based Care for Prevention of Cardiovascular Events
Cleerly
NCT06112418
Non-interventional Pre-screening Protocol Aims to Evaluate Participants for Potential Trial Eligibility in Future Clinical Trials/Studies Focusing on Metabolic and Psychiatric Health.
Clindove Research
NCT07106879
Wellness Program Outreach and Effectiveness
Massachusetts Institute of Technology
NCT06725511
Study of the Effect of Innate on the Inflammatory Response to Endotoxin
National Institute of Environmental Health Sciences (NIEHS)
NCT01143480
Fasting Insulin and HOMA-IR by Age, Sex, Race/Ethnicity, BMI, and PCOS Diagnosis
Lilli Health
NCT05950282
Our Voices Matter: Intervention for Depression in Youth
Ann & Robert H Lurie Children's Hospital of Chicago
NCT07216326
Stand Up for Your Health with a Sit-stand Desk
Medical College of Wisconsin
NCT05585190
Time-Restricted Feeding Intervention in Metabolically-Unhealthy Postmenopausal Women
Julie Pendergast
NCT04893226
Impact GLP-1 Agonists Following Bariatric
University of Missouri-Columbia
NCT06132477
Long Term Impact of Time-Restricted Eating on Parameters of Cardiometabolic Health
University of California, San Diego
NCT07189234
Animal and Plant Proteins and Glucose Metabolism
University of Missouri-Columbia
NCT03994367
Combined Oral Contraceptive Pill and Resistance Starch
University of Pennsylvania
NCT06852365
Physical Activity Targeting Metabolic Syndrome for Prevention of Breast Cancer in SAI Women
Rush University Medical Center
NCT06827704
Lifestyle Medicine: Establishing Clinical Approaches to Chronic Disease for Rural Patients
West Virginia School of Osteopathic Medicine
NCT06049420
Effects of Exercise and GLP-1 Agonism on Muscle Microvascular Perfusion and Insulin Action in Adults With Metabolic Syndrome
University of Virginia
NCT04575844
Feasibility of Reducing Cardiovascular Disease Risk Factors in Hispanics Through a Family-Based Community Intervention
Poudre Valley Health System
NCT05322876
The Effect of SGLT2 Inhibition on Adipose Inflammation and Endothelial Function
Vanderbilt University Medical Center
NCT05972564
Metabolic Adaptations to Weight Loss With and Without Exercise
University of Michigan
NCT05806801
Testing the Adipose Expandability Hypothesis in Vivo During Overfeeding
Pennington Biomedical Research Center
NCT04583514
Obesity, Metabolic Dysregulation and the Airway Epithelium in Asthmatics
University of Colorado, Denver
NCT03215836
VR Stimulation of Exercise Response in Sedentary Humans
Wayne State University
NCT07296991
Exercise and Carotid Artery Function in Metabolic Syndrome
University of Wisconsin, Madison
NCT07430839
Exercise Effects on Adipose Tissue Structure and Function
University of Michigan
NCT04812314
Probiotics and Gut Health
Penn State University
NCT03418857
Exercise and Time of Day in Type 2 Diabetes
Rutgers, The State University of New Jersey
NCT05108987
Impact of Supplemental Fiber on Gut and Vascular Health Related in Obesity Phenotypes
Ball State University
NCT07095426
Targeting Metabolic Syndrome From the Emergency Department Through Mixed-Methods: Pilot Trial
Indiana University
NCT07119658
Use of Continuous Glucose Monitoring in Non-Diabetic Population to Compliment Signos Mobile Health Platform
Signos
NCT05121844
Signos DM2 Empowerment Study (SIGNOS-CGM-EMPOWER-201-2022)
Signos
NCT05874635
The PIVOT Trial: Project on EHR-Integrated Lifestyle Interventions for Adults Aged Fifty and Older
University of Illinois at Chicago
NCT05654142
Northern Manhattan Study of Metabolism and Mind
Columbia University
NCT02470260
Using Signos mHealth Platform in Adults for Weight Management
Signos
NCT06214221
FIT Families Multicomponent Obesity Intervention for African American Adolescents
Medical University of South Carolina
NCT04974554
Role of Immune System in Obesity-related Inflammation and Cardiometabolic Risk
Washington University School of Medicine
NCT01104220
Diet and Health in Adults With Metabolic Syndrome
University of Arkansas, Fayetteville
NCT03935048
Causal Mechanisms in Adolescent Arterial Stiffness
Baylor College of Medicine
NCT04128969
Almonds to Improve Gut Health and Decrease Inflammation
Oregon State University
NCT05790564
Healthy Lifestyles: A Home Based Physical Activity Intervention in Persons Living With HIV
Georgetown University
NCT05896852
Feasibility of the Paso Program for Patients With Metabolic Dysfunction Associated Steatotic Liver Disease
Baylor College of Medicine
NCT06854185
Effects of Pulse Consumption, Gut Microbiome, and Appetite in Healthy Participants
University of Missouri-Columbia
NCT07043712
Determine How Consumption of Dairy Fat Fractions Rich in Phospholipids and Proteins Influence Inflammation in the Fed State-Phase 1
University of California, Davis
NCT01811329
Food is Medicine vs Lifestyle Medicine For Cardiovascular Kidney Metabolic (CKM) Syndrome
Rutgers, The State University of New Jersey
NCT06461273
Understanding Components of Mind-body Exercise for Physical Activity Engagement in Metabolic Syndrome
Beth Israel Deaconess Medical Center
NCT05242640
Plant-based Diet for Kidney Transplant Recipients
George Washington University
NCT06186843
Determine How Consumption of Dairy Fat as Cheese Influences Inflammation-Phase 2
University of California, Davis
NCT01803633
Evaluating the Navajo Community Outreach and Patient Empowerment (COPE) Program
Brigham and Women's Hospital
NCT03326206
Effects of Infant Egg Consumption on Child Health and Cognition Development
State University of New York at Buffalo
NCT04345185
Association of Genes to Resistance to Weight Loss in Obese Patients
Interleukin Genetics
NCT00858221
Slowing HEART diSease With Lifestyle and Omega-3 Fatty Acids
Beth Israel Deaconess Medical Center
NCT01624727
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 3 |
| Phase 2 | 6 |
| Phase 3 | 1 |
| Phase 4 | 6 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Metabolic Syndrome Trial Landscape
104 indexed Metabolic Syndrome studies · 28 recruiting (27%).
Phase mix: 7 late (III/IV) vs 9 early (I/II).
Top sponsor: University of California, Davis (5 trials), 9 others listed. 50 shown below, recruiting first.
How to read this condition's trial landscape
That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Metabolic Syndrome?
PlainTrial tracks 104 US clinical trials for Metabolic Syndrome, of which 28 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Metabolic Syndrome?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.