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Metabolic Syndrome: full-pipeline trial registry
28 of 104 indexed Metabolic Syndrome trials are currently recruiting.
Corpus placement: #129 of 28,707 conditions by registered trial count.
104 US clinical trials · 28 currently recruiting · #129 of 28,707 conditions by registered trial count
Metabolic Syndrome: 104 US clinical trials tracked, 28 recruiting.
Metabolic Syndrome is the subject of 104 registered US clinical trials on ClinicalTrials.gov, 28 of them currently open to new participants. 7 are in Phase 3-4 (later-stage) and 9 in Phase 1-2 (earlier-stage). The most active sponsor is University of California, Davis, running 5 of these trials.
Enrollment posture brief
Registry condition metabolic-syndrome
OPEN 28 | RECR 27% | LATE 7 | EARLY 9 | RANK #129 | SPON 5
Volume-matched condition peers
Nearest open-share peer: Cancer Survivor (27% recruiting · 26 trials)
Metabolic Syndrome lists 28 open slots (27% of 104 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Metabolic Syndrome on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Metabolic Syndrome is recruiting below its size-band peers.
28 of 104 indexed trials (26.9%) are open to enrollment, against a 37.1% average across 139 conditions with 100+ trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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Sponsorship of Metabolic Syndrome trials is spread across many organizations.
University of California, Davis accounts for 5 of 104 trials (4.8%). 80 distinct sponsors appear on at least one study for this condition label.
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Most Metabolic Syndrome trials plan to enrol fewer than 100 people.
Median target enrolment is 55 among the 103 trials that report a genuine target (sentinel values excluded). 70 of those (68%) plan for fewer than 100 participants.
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Metabolic Syndrome research is mostly interventional.
88 interventional and 16 observational studies make up this index (84.6% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
104 total, page 1 of 3
Triage Survey for Cardiovascular, Obesity, and Related Endocrine Trial Eligibility
Brooklyn Clinical Research
NCT06412536
A Randomized Comparison of Stage-Based Care Versus Risk Factor-Based Care for Prevention of Cardiovascular Events
Cleerly
NCT06112418
Non-interventional Pre-screening Protocol Aims to Evaluate Participants for Potential Trial Eligibility in Future Clinical Trials/Studies Focusing on Metabolic and Psychiatric Health.
Clindove Research
NCT07106879
Wellness Program Outreach and Effectiveness
Massachusetts Institute of Technology
NCT06725511
Study of the Effect of Innate on the Inflammatory Response to Endotoxin
National Institute of Environmental Health Sciences (NIEHS)
NCT01143480
Fasting Insulin and HOMA-IR by Age, Sex, Race/Ethnicity, BMI, and PCOS Diagnosis
Lilli Health
NCT05950282
Our Voices Matter: Intervention for Depression in Youth
Ann & Robert H Lurie Children's Hospital of Chicago
NCT07216326
Stand Up for Your Health with a Sit-stand Desk
Medical College of Wisconsin
NCT05585190
Time-Restricted Feeding Intervention in Metabolically-Unhealthy Postmenopausal Women
Julie Pendergast
NCT04893226
Impact GLP-1 Agonists Following Bariatric
University of Missouri-Columbia
NCT06132477
Long Term Impact of Time-Restricted Eating on Parameters of Cardiometabolic Health
University of California, San Diego
NCT07189234
Animal and Plant Proteins and Glucose Metabolism
University of Missouri-Columbia
NCT03994367
Combined Oral Contraceptive Pill and Resistance Starch
University of Pennsylvania
NCT06852365
Physical Activity Targeting Metabolic Syndrome for Prevention of Breast Cancer in SAI Women
Rush University Medical Center
NCT06827704
Lifestyle Medicine: Establishing Clinical Approaches to Chronic Disease for Rural Patients
West Virginia School of Osteopathic Medicine
NCT06049420
Effects of Exercise and GLP-1 Agonism on Muscle Microvascular Perfusion and Insulin Action in Adults With Metabolic Syndrome
University of Virginia
NCT04575844
Feasibility of Reducing Cardiovascular Disease Risk Factors in Hispanics Through a Family-Based Community Intervention
Poudre Valley Health System
NCT05322876
The Effect of SGLT2 Inhibition on Adipose Inflammation and Endothelial Function
Vanderbilt University Medical Center
NCT05972564
Metabolic Adaptations to Weight Loss With and Without Exercise
University of Michigan
NCT05806801
Testing the Adipose Expandability Hypothesis in Vivo During Overfeeding
Pennington Biomedical Research Center
NCT04583514
Obesity, Metabolic Dysregulation and the Airway Epithelium in Asthmatics
University of Colorado, Denver
NCT03215836
VR Stimulation of Exercise Response in Sedentary Humans
Wayne State University
NCT07296991
Exercise and Carotid Artery Function in Metabolic Syndrome
University of Wisconsin, Madison
NCT07430839
Exercise Effects on Adipose Tissue Structure and Function
University of Michigan
NCT04812314
Probiotics and Gut Health
Penn State University
NCT03418857
Exercise and Time of Day in Type 2 Diabetes
Rutgers, The State University of New Jersey
NCT05108987
Impact of Supplemental Fiber on Gut and Vascular Health Related in Obesity Phenotypes
Ball State University
NCT07095426
Targeting Metabolic Syndrome From the Emergency Department Through Mixed-Methods: Pilot Trial
Indiana University
NCT07119658
Use of Continuous Glucose Monitoring in Non-Diabetic Population to Compliment Signos Mobile Health Platform
Signos
NCT05121844
Signos DM2 Empowerment Study (SIGNOS-CGM-EMPOWER-201-2022)
Signos
NCT05874635
The PIVOT Trial: Project on EHR-Integrated Lifestyle Interventions for Adults Aged Fifty and Older
University of Illinois at Chicago
NCT05654142
Northern Manhattan Study of Metabolism and Mind
Columbia University
NCT02470260
Using Signos mHealth Platform in Adults for Weight Management
Signos
NCT06214221
FIT Families Multicomponent Obesity Intervention for African American Adolescents
Medical University of South Carolina
NCT04974554
Role of Immune System in Obesity-related Inflammation and Cardiometabolic Risk
Washington University School of Medicine
NCT01104220
Diet and Health in Adults With Metabolic Syndrome
University of Arkansas, Fayetteville
NCT03935048
Causal Mechanisms in Adolescent Arterial Stiffness
Baylor College of Medicine
NCT04128969
Almonds to Improve Gut Health and Decrease Inflammation
Oregon State University
NCT05790564
Healthy Lifestyles: A Home Based Physical Activity Intervention in Persons Living With HIV
Georgetown University
NCT05896852
Feasibility of the Paso Program for Patients With Metabolic Dysfunction Associated Steatotic Liver Disease
Baylor College of Medicine
NCT06854185
Effects of Pulse Consumption, Gut Microbiome, and Appetite in Healthy Participants
University of Missouri-Columbia
NCT07043712
Determine How Consumption of Dairy Fat Fractions Rich in Phospholipids and Proteins Influence Inflammation in the Fed State-Phase 1
University of California, Davis
NCT01811329
Food is Medicine vs Lifestyle Medicine For Cardiovascular Kidney Metabolic (CKM) Syndrome
Rutgers, The State University of New Jersey
NCT06461273
Understanding Components of Mind-body Exercise for Physical Activity Engagement in Metabolic Syndrome
Beth Israel Deaconess Medical Center
NCT05242640
Plant-based Diet for Kidney Transplant Recipients
George Washington University
NCT06186843
Determine How Consumption of Dairy Fat as Cheese Influences Inflammation-Phase 2
University of California, Davis
NCT01803633
Evaluating the Navajo Community Outreach and Patient Empowerment (COPE) Program
Brigham and Women's Hospital
NCT03326206
Effects of Infant Egg Consumption on Child Health and Cognition Development
State University of New York at Buffalo
NCT04345185
Association of Genes to Resistance to Weight Loss in Obese Patients
Interleukin Genetics
NCT00858221
Slowing HEART diSease With Lifestyle and Omega-3 Fatty Acids
Beth Israel Deaconess Medical Center
NCT01624727
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 3 |
| Phase 2 | 6 |
| Phase 3 | 1 |
| Phase 4 | 6 |
Top Sponsors
Named interventions
Most-linked intervention names on Metabolic Syndrome records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Metabolic Syndrome trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Metabolic Syndrome page
104 registered trials, 28 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 28 Metabolic Syndrome trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- University of California, Davis sponsors the most Metabolic Syndrome trials on record, review their full trial history before evaluating a specific study. See University of California, Davis's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Metabolic Syndrome condition card totals 104 registered trials; most-linked intervention Placebo; top US site state California. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.