Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT04128969 · ClinicalTrials.gov registry record · Phase 2
Causal Mechanisms in Adolescent Arterial Stiffness
A Phase 2 study of Metabolic Syndrome and Pediatric Obesity, sponsored by Baylor College of Medicine.
- Active
- Registry status
- Phase 2
- Development phase
- 90
- Enrollment target
- 1
- Study location
NCT04128969: Active Phase 2 study of Metabolic Syndrome and Pediatric Obesity, sponsored by Baylor College of Medicine.
NCT04128969 is a Phase 2 study of Metabolic Syndrome and Pediatric Obesity that is active but no longer recruiting, run by Baylor College of Medicine. The registered enrollment target is 90 participants, below the 1,204-participant average among 102 other Metabolic Syndrome trials with a reported enrollment target (93% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04128969, a Phase 2 study of Metabolic Syndrome and Pediatric Obesity, is active but no longer recruiting, sponsored by Baylor College of Medicine.
- ACTIVE NOT RECRUITING
- Registry status
- Phase 2
- Development phase
- 90 participants
- Enrollment target
- 1
- Study location
Study Summary
Hardening of the blood vessels, called arterial stiffness, is a risk factor for future heart disease and its causes are unclear. The proposed study will 1) randomly assign adolescents at high risk of stiffening blood vessels to take a protein supplement called carnitine and study its effects on arterial stiffening and 2) study carnitine related genes for their effect on arterial stiffening. The study will definitively establish a role for carnitine action as a cause of stiffening blood vessels and signal a way to treat or prevent stiffening.
Primary Outcome
Carotid Femoral Pulse Wave Velocity will be measured noninvasively using applanation tonometry.
Conditions Studied
Interventions
- DIETARY_SUPPLEMENT CS+
- DIETARY_SUPPLEMENT CS-
Study Locations (1)
Texas
- Texas Children's Hospital - Houston
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 90 participants |
| Start Date | 2020-02-01 |
| Est. Completion | 2026-08-31 |
| Phase | Phase 2 |
What the registry record for NCT04128969 still lists
NCT04128969 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 90 participants, a relatively small participant target, below the 1,204-participant average among 102 other Metabolic Syndrome trials with a reported enrollment target (93% lower).
The record links to 6 conditions, with Metabolic Syndrome appearing as the primary indexed condition, and to 2 interventions - of which CS+ is the first listed.
NCT04128969 reports a single indexed study location in Texas.
Frequently Asked Questions
What is clinical trial NCT04128969 about?
NCT04128969 is a clinical study titled "Causal Mechanisms in Adolescent Arterial Stiffness". Hardening of the blood vessels, called arterial stiffness, is a risk factor for future heart disease and its causes are unclear. The proposed study will 1) randomly assign adolescents at high risk of stiffening blood vessels to take a protein supplement called carnitine and study its effects on arte...
What is the current status of trial NCT04128969?
This trial is currently active not recruiting. It is a Phase 2 study. The enrollment target is 90 participants. The study started on 2020-02-01. Estimated completion is 2026-08-31.
What conditions does trial NCT04128969 study?
This clinical trial studies the following conditions: Metabolic Syndrome, Pediatric Obesity, Dyslipidemias, Lipid Disorder, Insulin Resistance Syndrome.
What interventions are being tested in trial NCT04128969?
The interventions under investigation include: CS+ (DIETARY_SUPPLEMENT), CS- (DIETARY_SUPPLEMENT).
Who is sponsoring clinical trial NCT04128969?
This trial is sponsored by Baylor College of Medicine, which has 616 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT04128969 being conducted?
This trial has 1 study location across Texas. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Metabolic Syndrome
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT04128969's enrollment target sits among peer trials
90 37th of 102 higher than 64 of 102 other Metabolic Syndrome trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Metabolic Syndrome trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
-
Combined Oral Contraceptive Pill and Resistance Starch
RECRUITING · Phase 2
-
Long Term Impact of Time-Restricted Eating on Parameters of Cardiometabolic Health
RECRUITING · Phase 2
-
Metformin in Kidney Disease
COMPLETED · Phase 2
-
The Health-Promoting Role of Pears in Men and Women With Metabolic Syndrome
COMPLETED · Phase 2
-
Effects of Human Leptin Replacement
COMPLETED · Phase 2
-
Metabolic Adaptations to Weight Loss With and Without Exercise
RECRUITING · NA
Nationwide trials with similar profiles
Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.
Similar enrollment target
- NCT02521311 · 90 participants · Phase 2
Assessment of Clemastine Fumarate as a Remyelinating Agent in Acute Optic Neuritis (ReCOVER)
- NCT02939573 · 90 participants · Phase 2
A Randomized Multicenter Study for Isolated Skin Vasculitis
- NCT03128879 · 90 participants · Phase 2
Venetoclax With Ibrutinib or Acalabrutinib in Pts. With High-risk CLL
- NCT03184038 · 90 participants · NA
Neurocognition in Patients With Multiple Brain Metastases Treated With Radiosurgery
Similar registry start date
- NCT05962346 · started 2026-12 · NA
Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia
- NCT07125183 · started 2026-12 · Phase 2
Study on Efficacy and Tolerability of Weekly Doxorubicin in Elderly Patients With Advanced or Metastatic Leiomyosarcoma
- NCT07292298 · started 2026-11 · Phase 2
Phase 2 Single-Arm Rectal Cancer Brachytherapy for Patients With Low-Lying Residual Adenocarcinoma After Total Neoadjuvant Therapy to Improve Organ Preservation Rates
- NCT04263285 · started 2026-10 · NA
Treatment of Depression Post-SCI