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NCT06666621 · ClinicalTrials.gov registry record · Phase 4

Endogenous Opioid Response to Injections

A Phase 4 study of Low Back Pain and Zygapophyseal Joint Arthritis, sponsored by Middle Tennessee Research Institute.

Recruiting
Registry status
Phase 4
Development phase
33
Enrollment target
1
Study location

NCT06666621 is a Phase 4 study of Low Back Pain and Zygapophyseal Joint Arthritis that is actively recruiting participants, run by Middle Tennessee Research Institute. The registered enrollment target is 33 participants, below the 504-participant average among 122 other Low Back Pain trials with a reported enrollment target (93% lower). The trial reports 1 study location across 1 state.

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The verdict

NCT06666621, a Phase 4 study of Low Back Pain and Zygapophyseal Joint Arthritis, is actively recruiting participants, sponsored by Middle Tennessee Research Institute.

RECRUITING
Registry status
Phase 4
Development phase
33 participants
Enrollment target
1
Study location

Study Summary

This study will study pain relief after spine injections that are used to guide care. Some improvements in pain from a procedure might be from placebo effect rather than the physiological effect of the procedure. The study will use naloxone to reverse the effect of the body's internal placebo system after a spine injection, so the placebo effect and the injection effect can be measured separately. This process may improve the understanding of spine injections and their ability to guide pain care.

Conditions Studied

Low Back Pain Zygapophyseal Joint Arthritis

Interventions

  • DRUG Normal saline infusion
  • DRUG Naloxone infusion

Study Locations (1)

Tennessee

  • VA Tennessee Valley Healthcare System - Nashville

Trial Details

FieldValue
Enrollment Target 33 participants
Start Date 2024-08-22
Est. Completion 2026-02
Phase Phase 4

Sponsor

Middle Tennessee Research Institute

1 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT06666621

The ClinicalTrials.gov registry entry for NCT06666621 describes a study currently listed as recruiting, categorized as Phase 4. The registered enrollment target is 33 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 504-participant average among 122 other Low Back Pain trials with a reported enrollment target (93% lower). The listed sponsor is Middle Tennessee Research Institute, which has 1 total studies on file at ClinicalTrials.gov.

The record links to 2 conditions, with Low Back Pain appearing as the primary indexed condition, and to 2 interventions - of which Normal saline infusion is the first listed.

NCT06666621 reports 1 study location spanning 1 distinct geographic area - top geographies include Tennessee.

Frequently Asked Questions

What is clinical trial NCT06666621 about?

NCT06666621 is a clinical study titled "Endogenous Opioid Response to Injections". This study will study pain relief after spine injections that are used to guide care. Some improvements in pain from a procedure might be from placebo effect rather than the physiological effect of the procedure. The study will use naloxone to reverse the effect of the body's internal placebo system...

What is the current status of trial NCT06666621?

This trial is currently recruiting. It is a Phase 4 study. The enrollment target is 33 participants. The study started on 2024-08-22. Estimated completion is 2026-02.

What conditions does trial NCT06666621 study?

This clinical trial studies the following conditions: Low Back Pain, Zygapophyseal Joint Arthritis.

What interventions are being tested in trial NCT06666621?

The interventions under investigation include: Normal saline infusion (DRUG), Naloxone infusion (DRUG).

Who is sponsoring clinical trial NCT06666621?

This trial is sponsored by Middle Tennessee Research Institute, which has 1 total clinical trials registered on ClinicalTrials.gov.

Where is trial NCT06666621 being conducted?

This trial has 1 study location across Tennessee. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

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Data sourced from official public datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page mirrors this trial's own ClinicalTrials.gov registry record, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.