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ClinicalTrials.gov 31 recruiting now official registry

Low Back Pain clinical trials

31 of 123 indexed Low Back Pain trials are currently recruiting.

123 US clinical trials · 31 currently recruiting

Low Back Pain is the subject of 123 registered US clinical trials on ClinicalTrials.gov, 31 of them currently open to new participants. 20 are in Phase 3-4 (later-stage) and 12 in Phase 1-2 (earlier-stage). The most active sponsor is University of Utah, running 8 of these trials.

The research picture

Low Back Pain has 123 registered US clinical trials, 31 of them open to new participants right now, about 25% of the total.

31
recruiting participants now
25%
of trials open to enrollment
20
in Phase 3–4 (later-stage)
8
top sponsor: University of Utah
Phase 17Phase 25Phase 312Phase 48

Active & Recent Trials

123 total, page 2 of 3

COMPLETED Phase 3 625 participants

Efficacy and Safety of Hydrocodone Bitartrate Extended-Release Tablets for Moderate to Severe Chronic Low Back Pain

Teva Branded Pharmaceutical Products R&D

NCT01789970

COMPLETED NA 580 participants

Low Back Pain Patient Education Evaluation

Stanford University

NCT00000408

COMPLETED Phase 3 455 participants

Analgesic Efficacy and Management of Opioid-induced Constipation (OIC) for Uncontrolled Moderate - Severe Low Back Pain

Purdue Pharma

NCT01427270

COMPLETED Phase 3 455 participants

Osteopathic Health Outcomes in Chronic Low Back Pain (OSTEOPATHIC) Trial

University of North Texas Health Science Center

NCT00315120

COMPLETED Phase 3 450 participants

A Study of Oxycodone/Naloxone Controlled-release Tablets (OXN) to Assess Analgesic Efficacy and Management of Opioid-induced Constipation (OIC) in Opioid-experienced Subjects With Moderate to Severe Chronic Low Back Pain

Purdue Pharma

NCT01427283

COMPLETED NA 400 participants

Osteopathic Manipulative Medicine in Pregnancy: Physiologic and Clinical Effects

University of North Texas Health Science Center

NCT00426244

COMPLETED Phase 3 376 participants

Study of COV795 in Subjects With Osteoarthritis or Chronic Low Back Pain

Mallinckrodt

NCT01451385

COMPLETED 346 participants

Predictive Factors for LBP Interventional Treatment Outcomes

Johns Hopkins University

NCT02329951

COMPLETED Phase 3 342 participants

Comparison of CAM and Conventional Mind-Body Therapies for Chronic Back Pain

Kaiser Permanente

NCT01467843

COMPLETED NA 316 participants

PNE Effectiveness Cluster Trial

University of Utah

NCT03168165

COMPLETED NA 282 participants

Aging Successfully With Pain

University of Pittsburgh

NCT01405716

COMPLETED Early Phase 1 240 participants

Effectiveness of Caudal Epidural Injections in Treatment of Chronic Low Back and Lower Extremity Pain

Pain Management Center of Paducah

NCT00370799

COMPLETED NA 221 participants

Effect of Spinal Manipulation on Sensorimotor Functions in Back Pain Patients

Palmer College of Chiropractic

NCT00830596

COMPLETED Phase 4 198 participants

Acute Low Back Pain. Topical Diclofenac and Oral Ibuprofen.

Montefiore Medical Center

NCT04611529

COMPLETED Phase 4 198 participants

A Comparison of NSAIDs for Acute, Non-radicular Low Back Pain.

Montefiore Medical Center

NCT03861611

COMPLETED 196 participants

Rest Before Physical Therapy in Adolescents With Active Spondylolysis and Spondylolisthesis

Nationwide Children's Hospital

NCT02332200

COMPLETED NA 177 participants

Power Over Pain (POP) Study

University of Washington

NCT01800604

COMPLETED NA 166 participants

Electrical Stimulation for the Treatment of Back Pain Using Peripheral Nerve Stimulation (PNS)

SPR Therapeutics

NCT03179202

COMPLETED NA 164 participants

The Effect of AposTherapy on Pain and Function in a Non Specific Low Back Pain

Montefiore Medical Center

NCT03167671

COMPLETED NA 162 participants

The RELIEF Study - Researching the Effectiveness of Lumbar Interventions for Enhancing Function

Ohio University

NCT01854892

COMPLETED NA 155 participants

A Randomized Controlled Trial of Best Approach to Care Compared to Diversified Chiropractic Adjustive Technique

Parker College of Chiropractic

NCT00163124

COMPLETED NA 126 participants

Telehealth Physical Therapy for Chronic Back Pain - Ancillary Study to NCT03859713

University of Utah

NCT05103462

COMPLETED NA 120 participants

Effectiveness of Lumbar Facet Joint Nerve Blocks

Pain Management Center of Paducah

NCT00355914

COMPLETED NA 120 participants

Study of Opioid Use After Lumbar and Cervical Spine Surgery

Brooke Army Medical Center

NCT02674711

COMPLETED NA 119 participants

Low-Cost Tool for Compliance and Treatment-Tracking of Low Back Pain Patients

Mayo Clinic

NCT03478007

COMPLETED Phase 1 110 participants

The Mechanisms of Manual Therapy in the Treatment of Low Back Pain

University of Florida

NCT01168999

COMPLETED NA 108 participants

Effectiveness of Adding Behavioral Therapy to Physical Therapy to Treat Low Back Pain

University of Florida

NCT00373867

COMPLETED NA 102 participants

Mechanisms of Specific Trunk Exercises in Low Back Pain

University of Vermont

NCT01362049

COMPLETED NA 102 participants

A Follow-up Comparison of Active Versus Passive Manual Therapy in Patients With Low Back Pain

St. Ambrose University

NCT03758807

COMPLETED Phase 3 100 participants

The Use of Methylsulfonylmethane (MSM) in the Treatment of Low Back Pain

Mike O'Callaghan Military Hospital

NCT02268305

COMPLETED NA 100 participants

High Level Pulsed Heat Versus Low Level Steady Heat in Subjects With Chronic Low Back Pain

Soovu Labs

NCT04109703

COMPLETED NA 100 participants

Evaluation of Efficacy and Comfort: A Trial on the Incrediwear Back Brace in Patients With Chronic Lower Back Pain

Johns Hopkins University

NCT06126887

COMPLETED NA 98 participants

Comparison of Extensible and Inextensible Lumbosacral Orthoses for Lower Back Pain

Medical University of South Carolina

NCT01933399

COMPLETED NA 97 participants

Soft Active Back Exosuit to Reduce Workplace Back Pain

Wyss Institute at Harvard University

NCT05802914

COMPLETED NA 90 participants

Using Structural Health Monitoring to Improve Diagnosis and Treatment of Low Back Injury in U.S. Service Members- Phase 2

Baylor University

NCT02352532

COMPLETED Phase 1 86 participants

Development and Evaluation of Computerized Chemosensory Based Orbitofrontal Networks Training for Treatment of Pain

Evon Medics

NCT06218407

COMPLETED NA 79 participants

Brain Mechanisms of Acupuncture Treatment in Chronic Low Back Pain

Brigham and Women's Hospital

NCT01595451

COMPLETED NA 78 participants

Effect of Nitrous Oxide in Treating Neuropathic Pain: A Study in Chronic Low Back Pain Patients

The Cleveland Clinic

NCT01172600

COMPLETED NA 76 participants

Patient Education for Patients With Back Pain Referred to Physical Therapy

University of Utah

NCT02648373

COMPLETED Phase 2 75 participants

Magnets in the Treatment of Sciatica

National Institute of Dental and Craniofacial Research (NIDCR)

NCT00044109

COMPLETED NA 72 participants

Resistance Exercise Effects on Fear Avoidance and Physical Function in Obese Older Adults With Low Back Pain

University of Florida

NCT01250262

COMPLETED 69 participants

Recurrent Low Back Pain:Linking Mechanisms to Outcomes

Drexel University

NCT01085604

COMPLETED NA 66 participants

Effect of Music and Other Audio Recordings for Chronic Pain in Aging Adults

Baylor University

NCT04785963

COMPLETED Phase 2 64 participants

Pregnancy-Related Low Back Pain and Complementary and Alternative Medicine (CAM) Treatment

Oregon Health and Science University

NCT00937365

COMPLETED NA 62 participants

Study of Low Level Laser Therapy to Treat Low Back Pain

Erchonia Corporation

NCT01835756

COMPLETED NA 60 participants

Interventional Study of Effects on Spine Height With Two Unloading Positions

Texas Tech University Health Sciences Center

NCT01048749

COMPLETED Phase 3 60 participants

Acupuncture Analgesia in Relation to Psychiatric Comorbidity

Brigham and Women's Hospital

NCT00307788

COMPLETED NA 56 participants

Core Strengthening for DRA in Postpartum Women

Hospital for Special Surgery, New York

NCT03595696

COMPLETED Phase 4 51 participants

True Functional Restoration and Analgesia in Non-Radicular Low Back Pain

Shirley Ryan AbilityLab

NCT01455519

COMPLETED NA 48 participants

Battlefield Acupuncture for Low Back Pain

The Geneva Foundation

NCT03491124

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Phase Distribution

PhaseTrial count
Phase 1 7
Phase 2 5
Phase 3 12
Phase 4 8

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Low Back Pain Trial Landscape

123 indexed Low Back Pain studies · 31 recruiting (25%).

Phase mix: 20 late (III/IV) vs 12 early (I/II).

Top sponsor: University of Utah (8 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Low Back Pain?

PlainTrial tracks 123 US clinical trials for Low Back Pain, of which 31 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Low Back Pain?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.