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Low Back Pain: later-stage trial registry
31 of 123 indexed Low Back Pain trials are currently recruiting, with more weight in Phase 3-4.
Corpus placement: #97 of 28,707 conditions by registered trial count.
123 US clinical trials · 31 currently recruiting · #97 of 28,707 conditions by registered trial count
Low Back Pain: 123 US clinical trials tracked, 31 recruiting.
Low Back Pain is the subject of 123 registered US clinical trials on ClinicalTrials.gov, 31 of them currently open to new participants. 20 are in Phase 3-4 (later-stage) and 12 in Phase 1-2 (earlier-stage). The most active sponsor is University of Utah, running 8 of these trials.
Enrollment posture brief
Registry condition low-back-pain
OPEN 31 | RECR 25% | LATE 20 | EARLY 12 | RANK #97 | SPON 8
Volume-matched condition peers
Nearest open-share peer: Overweight (25% recruiting · 198 trials)
Low Back Pain lists 31 open slots (25% of 123 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Low Back Pain on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Low Back Pain is recruiting below its size-band peers.
31 of 123 indexed trials (25.2%) are open to enrollment, against a 37.1% average across 139 conditions with 100+ trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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Sponsorship of Low Back Pain trials is spread across many organizations.
University of Utah accounts for 8 of 123 trials (6.5%). 80 distinct sponsors appear on at least one study for this condition label.
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Typical Low Back Pain enrolment sits around 97 participants.
Median target enrolment is 97 among the 123 trials that report a genuine target (sentinel values excluded). 63 of those (51.2%) plan for fewer than 100 participants.
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Low Back Pain research is mostly interventional.
108 interventional and 15 observational studies make up this index (87.8% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
123 total, page 2 of 3
Efficacy and Safety of Hydrocodone Bitartrate Extended-Release Tablets for Moderate to Severe Chronic Low Back Pain
Teva Branded Pharmaceutical Products R&D
NCT01789970
Low Back Pain Patient Education Evaluation
Stanford University
NCT00000408
Analgesic Efficacy and Management of Opioid-induced Constipation (OIC) for Uncontrolled Moderate - Severe Low Back Pain
Purdue Pharma
NCT01427270
Osteopathic Health Outcomes in Chronic Low Back Pain (OSTEOPATHIC) Trial
University of North Texas Health Science Center
NCT00315120
A Study of Oxycodone/Naloxone Controlled-release Tablets (OXN) to Assess Analgesic Efficacy and Management of Opioid-induced Constipation (OIC) in Opioid-experienced Subjects With Moderate to Severe Chronic Low Back Pain
Purdue Pharma
NCT01427283
Osteopathic Manipulative Medicine in Pregnancy: Physiologic and Clinical Effects
University of North Texas Health Science Center
NCT00426244
Study of COV795 in Subjects With Osteoarthritis or Chronic Low Back Pain
Mallinckrodt
NCT01451385
Predictive Factors for LBP Interventional Treatment Outcomes
Johns Hopkins University
NCT02329951
Comparison of CAM and Conventional Mind-Body Therapies for Chronic Back Pain
Kaiser Permanente
NCT01467843
PNE Effectiveness Cluster Trial
University of Utah
NCT03168165
Aging Successfully With Pain
University of Pittsburgh
NCT01405716
Effectiveness of Caudal Epidural Injections in Treatment of Chronic Low Back and Lower Extremity Pain
Pain Management Center of Paducah
NCT00370799
Effect of Spinal Manipulation on Sensorimotor Functions in Back Pain Patients
Palmer College of Chiropractic
NCT00830596
Acute Low Back Pain. Topical Diclofenac and Oral Ibuprofen.
Montefiore Medical Center
NCT04611529
A Comparison of NSAIDs for Acute, Non-radicular Low Back Pain.
Montefiore Medical Center
NCT03861611
Rest Before Physical Therapy in Adolescents With Active Spondylolysis and Spondylolisthesis
Nationwide Children's Hospital
NCT02332200
Power Over Pain (POP) Study
University of Washington
NCT01800604
Electrical Stimulation for the Treatment of Back Pain Using Peripheral Nerve Stimulation (PNS)
SPR Therapeutics
NCT03179202
The Effect of AposTherapy on Pain and Function in a Non Specific Low Back Pain
Montefiore Medical Center
NCT03167671
The RELIEF Study - Researching the Effectiveness of Lumbar Interventions for Enhancing Function
Ohio University
NCT01854892
A Randomized Controlled Trial of Best Approach to Care Compared to Diversified Chiropractic Adjustive Technique
Parker College of Chiropractic
NCT00163124
Telehealth Physical Therapy for Chronic Back Pain - Ancillary Study to NCT03859713
University of Utah
NCT05103462
Effectiveness of Lumbar Facet Joint Nerve Blocks
Pain Management Center of Paducah
NCT00355914
Study of Opioid Use After Lumbar and Cervical Spine Surgery
Brooke Army Medical Center
NCT02674711
Low-Cost Tool for Compliance and Treatment-Tracking of Low Back Pain Patients
Mayo Clinic
NCT03478007
The Mechanisms of Manual Therapy in the Treatment of Low Back Pain
University of Florida
NCT01168999
Effectiveness of Adding Behavioral Therapy to Physical Therapy to Treat Low Back Pain
University of Florida
NCT00373867
Mechanisms of Specific Trunk Exercises in Low Back Pain
University of Vermont
NCT01362049
A Follow-up Comparison of Active Versus Passive Manual Therapy in Patients With Low Back Pain
St. Ambrose University
NCT03758807
The Use of Methylsulfonylmethane (MSM) in the Treatment of Low Back Pain
Mike O'Callaghan Military Hospital
NCT02268305
High Level Pulsed Heat Versus Low Level Steady Heat in Subjects With Chronic Low Back Pain
Soovu Labs
NCT04109703
Evaluation of Efficacy and Comfort: A Trial on the Incrediwear Back Brace in Patients With Chronic Lower Back Pain
Johns Hopkins University
NCT06126887
Comparison of Extensible and Inextensible Lumbosacral Orthoses for Lower Back Pain
Medical University of South Carolina
NCT01933399
Soft Active Back Exosuit to Reduce Workplace Back Pain
Wyss Institute at Harvard University
NCT05802914
Using Structural Health Monitoring to Improve Diagnosis and Treatment of Low Back Injury in U.S. Service Members- Phase 2
Baylor University
NCT02352532
Development and Evaluation of Computerized Chemosensory Based Orbitofrontal Networks Training for Treatment of Pain
Evon Medics
NCT06218407
Brain Mechanisms of Acupuncture Treatment in Chronic Low Back Pain
Brigham and Women's Hospital
NCT01595451
Effect of Nitrous Oxide in Treating Neuropathic Pain: A Study in Chronic Low Back Pain Patients
The Cleveland Clinic
NCT01172600
Patient Education for Patients With Back Pain Referred to Physical Therapy
University of Utah
NCT02648373
Magnets in the Treatment of Sciatica
National Institute of Dental and Craniofacial Research (NIDCR)
NCT00044109
Resistance Exercise Effects on Fear Avoidance and Physical Function in Obese Older Adults With Low Back Pain
University of Florida
NCT01250262
Recurrent Low Back Pain:Linking Mechanisms to Outcomes
Drexel University
NCT01085604
Effect of Music and Other Audio Recordings for Chronic Pain in Aging Adults
Baylor University
NCT04785963
Pregnancy-Related Low Back Pain and Complementary and Alternative Medicine (CAM) Treatment
Oregon Health and Science University
NCT00937365
Study of Low Level Laser Therapy to Treat Low Back Pain
Erchonia Corporation
NCT01835756
Interventional Study of Effects on Spine Height With Two Unloading Positions
Texas Tech University Health Sciences Center
NCT01048749
Acupuncture Analgesia in Relation to Psychiatric Comorbidity
Brigham and Women's Hospital
NCT00307788
Core Strengthening for DRA in Postpartum Women
Hospital for Special Surgery, New York
NCT03595696
True Functional Restoration and Analgesia in Non-Radicular Low Back Pain
Shirley Ryan AbilityLab
NCT01455519
Battlefield Acupuncture for Low Back Pain
The Geneva Foundation
NCT03491124
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 7 |
| Phase 2 | 5 |
| Phase 3 | 12 |
| Phase 4 | 8 |
Top Sponsors
Named interventions
Most-linked intervention names on Low Back Pain records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Low Back Pain trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Low Back Pain page
123 registered trials, 31 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 31 Low Back Pain trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- University of Utah sponsors the most Low Back Pain trials on record, review their full trial history before evaluating a specific study. See University of Utah's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Low Back Pain condition card totals 123 registered trials; most-linked intervention Placebo; top US site state Texas. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.