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Bone Marrow Transplant From Partially Matched Donors and Nonmyeloablative Conditioning for Blood Cancers (BMT CTN 0603)
NCT00849147 · View on ClinicalTrials.gov ↗
Study Summary
Bone marrow transplants are one treatment option for people with leukemia or lymphoma. Family members or unrelated donors with a similar type of bone marrow usually donate their bone marrow to the transplant patients. This study will evaluate the effectiveness of a new type of bone marrow transplant-one that uses lower doses of chemotherapy and bone marrow donated from family members with only partially matched bone marrow-in people with leukemia or lymphoma.
Conditions Studied
Interventions
- BIOLOGICAL Haploidentical Bone Marrow Transplantation
- BIOLOGICAL GVHD prophylaxis
Study Locations (17)
California
- City of Hope National Medical Center — Duarte
- University of California San Diego Medical Center — La Jolla
Maryland
- University of Maryland, Greenbaum Cancer Center — Baltimore
- Johns Hopkins University/Sidney Kimmel Comprehensive Cancer Center (SKCCC) — Baltimore
Texas
- Baylor University Medical Center — Dallas
- Texas Transplant Institute — San Antonio
Florida
- University of Florida College of Medicine (Shands) — Gainesville
Georgia
- Bone Marrow Transplant Group of Georgia, Northside Hospital — Atlanta
Hawaii
- Kapi'olani Medical Center for Women and Children, University of Hawaii — Honolulu
Massachusetts
- DFCI, Massachusetts General Hospital — Boston
Michigan
- Karmanos Cancer Institute, Children's Hospital of Michigan — Detroit
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 55 participants |
| Start Date | 2008-10 |
| Est. Completion | 2013-11 |
| Phase | Phase 2 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT00849147
The ClinicalTrials.gov registry entry for NCT00849147 describes a study currently listed as completed. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 55 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Medical College of Wisconsin, which has 614 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 6 conditions, with Lymphoma, B-Cell appearing as the primary indexed condition, and to 2 interventions — of which Haploidentical Bone Marrow Transplantation is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT00849147 reports 17 study locations spanning 14 distinct geographic areas — top geographies include California, Maryland, Texas. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT00849147 about?
NCT00849147 is a clinical study titled "Bone Marrow Transplant From Partially Matched Donors and Nonmyeloablative Conditioning for Blood Cancers (BMT CTN 0603)". Bone marrow transplants are one treatment option for people with leukemia or lymphoma. Family members or unrelated donors with a similar type of bone marrow usually donate their bone marrow to the transplant patients. This study will evaluate the effectiveness of a new type of bone marrow transplant...
What is the current status of trial NCT00849147?
This trial is currently completed. It is a Phase 2 study. The enrollment target is 55 participants. The study started on 2008-10. Estimated completion is 2013-11.
What conditions does trial NCT00849147 study?
This clinical trial studies the following conditions: Lymphoma, B-Cell, Leukemia, Myeloid, Acute, Burkitt Lymphoma, Lymphoma, Large B-Cell, Diffuse, Lymphoma, Follicular. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT00849147?
The interventions under investigation include: Haploidentical Bone Marrow Transplantation (BIOLOGICAL), GVHD prophylaxis (BIOLOGICAL). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT00849147?
This trial is sponsored by Medical College of Wisconsin, which has 614 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT00849147 being conducted?
This trial has 17 study locations across California, Florida, Georgia, Hawaii, Maryland. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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