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NCT00353652 · ClinicalTrials.gov registry record · Phase 4
Effects of Thiazide Diuretics on Sympathetic Nervous System in Hypertension
A Phase 4 study of Hypertension, sponsored by University of Texas Southwestern Medical Center.
- Completed
- Registry status
- Phase 4
- Development phase
- 166
- Enrollment target
- 2
- Study locations
NCT00353652: Completed Phase 4 study of Hypertension, sponsored by University of Texas Southwestern Medical Center.
NCT00353652 is a Phase 4 study of Hypertension that has completed, run by University of Texas Southwestern Medical Center. The registered enrollment target is 166 participants, below the 3,507-participant average among 470 other Hypertension trials with a reported enrollment target (95% lower). The trial reports 2 study locations across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00353652, a Phase 4 study of Hypertension, has completed, sponsored by University of Texas Southwestern Medical Center.
- COMPLETED
- Registry status
- Phase 4
- Development phase
- 166 participants
- Enrollment target
- 2
- Study locations
Study Summary
Thiazide medications are often prescribed for individuals with high blood pressure, but research has shown that they may increase an individual's risk of developing diabetes. While it is unknown exactly how thiazide causes this response, it is likely that the nervous system is somehow involved. This study will evaluate the role of the nervous system in sugar metabolism, as well as determine the effect of thiazide and other medications on individuals with high blood pressure.
Conditions Studied
Interventions
- DRUG Study#1: chlorthalidone (CTD), titrated dose
- DRUG Study #1: spironolactone (SP), titrated dose
- DRUG Study# 2 chlorthalidone (CTD), fixed dose
- DRUG Study# 2 spironolactone (SP), fixed dose
- DRUG Study# 2 irbsesartan (IR), fixed dose
Study Locations (2)
Texas
- University of Texas Southwestern Medical Center at Dallas - Dallas
- University of Texas Southwestern Medical Center - Dallas
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 166 participants |
| Start Date | 2005-01 |
| Est. Completion | 2013-01 |
| Phase | Phase 4 |
What the finished NCT00353652 record still lists
NCT00353652 is an interventional study that assigns participants to a tested intervention. The registered 166 participants enrollment target is mid-sized for trials with a published cap, below the 3,507-participant average among 470 other Hypertension trials with a reported enrollment target (95% lower).
The record links to 1 condition, with Hypertension appearing as the primary indexed condition, and to 5 interventions - of which Study#1: chlorthalidone (CTD), titrated dose is the first listed.
NCT00353652 reports a single indexed study location in Texas.
Frequently Asked Questions
What is clinical trial NCT00353652 about?
NCT00353652 is a clinical study titled "Effects of Thiazide Diuretics on Sympathetic Nervous System in Hypertension". Thiazide medications are often prescribed for individuals with high blood pressure, but research has shown that they may increase an individual's risk of developing diabetes. While it is unknown exactly how thiazide causes this response, it is likely that the nervous system is somehow involved. This...
What is the current status of trial NCT00353652?
This trial is currently completed. It is a Phase 4 study. The enrollment target is 166 participants. The study started on 2005-01. Estimated completion is 2013-01.
What conditions does trial NCT00353652 study?
This clinical trial studies the following conditions: Hypertension.
What interventions are being tested in trial NCT00353652?
The interventions under investigation include: Study#1: chlorthalidone (CTD), titrated dose (DRUG), Study #1: spironolactone (SP), titrated dose (DRUG), Study# 2 chlorthalidone (CTD), fixed dose (DRUG), Study# 2 spironolactone (SP), fixed dose (DRUG), Study# 2 irbsesartan (IR), fixed dose (DRUG).
Who is sponsoring clinical trial NCT00353652?
This trial is sponsored by University of Texas Southwestern Medical Center, which has 837 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT00353652 being conducted?
This trial has 2 study locations across Texas. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Hypertension
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT00353652's enrollment target sits among peer trials
166 237th of 470 higher than 234 of 470 other Hypertension trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Hypertension trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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