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NCT04340596 · ClinicalTrials.gov registry record · Phase 1
Safety, Tolerability, and Efficacy of IL-15 Superagonist (N-803) With and Without Combination Broadly Neutralizing Antibodies to Induce HIV-1 Control During Analytic Treatment Interruption
A Phase 1 study of HIV Infection, sponsored by National Institute of Allergy and Infectious Diseases (NIAID).
- Active
- Registry status
- Phase 1
- Development phase
- 118
- Enrollment target
- 14
- Study locations
NCT04340596: Active Phase 1 study of HIV Infection, sponsored by National Institute of Allergy and Infectious Diseases (NIAID).
NCT04340596 is a Phase 1 study of HIV Infection that is active but no longer recruiting, run by National Institute of Allergy and Infectious Diseases (NIAID). The registered enrollment target is 118 participants, below the 241-participant average among 73 other HIV Infection trials with a reported enrollment target (51% lower). The trial reports 14 study locations across 11 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04340596, a Phase 1 study of HIV Infection, is active but no longer recruiting, sponsored by National Institute of Allergy and Infectious Diseases (NIAID).
- ACTIVE NOT RECRUITING
- Registry status
- Phase 1
- Development phase
- 118 participants
- Enrollment target
- 14
- Study locations
Study Summary
The purpose of this study is to evaluate the safety, tolerability, and efficacy of N-803, an IL-15 superagonist, with or without combination broadly neutralizing antibodies (bNAbs), to induce HIV-1 control during analytic treatment interruption (ATI).
Conditions Studied
Interventions
- BIOLOGICAL VRC07-523LS
- BIOLOGICAL N-803 (IL-15 Superagonist)
- BIOLOGICAL 10-1074
Study Locations (14)
California
- UCLA CARE Center CRS - Los Angeles
- UCSD Antiviral Research Center CRS (Site ID: 701) - San Diego
- University of California, San Fransisco HIV/AIDS CRS - San Francisco
New York
- Columbia P&S CRS - New York
- Weill Cornell Uptown CRS (Site ID: 7803) - New York
Alabama
- Alabama CRS (Site ID# 31788) - Birmingham
District of Columbia
- Whitman-Walker Institute, Inc. CRS (Site ID: 31791) - Washington D.C.
Illinois
- Northwestern University CRS - Chicago
Massachusetts
- Massachusetts General Hospital CRS (MGH CRS) (Site ID: 101) - Boston
Missouri
- Washington University Therapeutics (WT) CRS - St Louis
New Jersey
- New Jersey Medical School Clinical Research Center CRS [Site ID: 31786] - Newark
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 118 participants |
| Start Date | 2021-05-21 |
| Est. Completion | 2026-12-30 |
| Phase | Phase 1 |
What the registry record for NCT04340596 still lists
NCT04340596 is an interventional study that assigns participants to a tested intervention. The registered 118 participants enrollment target is mid-sized for trials with a published cap, below the 241-participant average among 73 other HIV Infection trials with a reported enrollment target (51% lower).
The record links to 1 condition, with HIV Infection appearing as the primary indexed condition, and to 3 interventions - of which VRC07-523LS is the first listed.
NCT04340596 lists 14 locations in 11 states (California, New York, Alabama).
Frequently Asked Questions
What is clinical trial NCT04340596 about?
NCT04340596 is a clinical study titled "Safety, Tolerability, and Efficacy of IL-15 Superagonist (N-803) With and Without Combination Broadly Neutralizing Antibodies to Induce HIV-1 Control During Analytic Treatment Interruption". The purpose of this study is to evaluate the safety, tolerability, and efficacy of N-803, an IL-15 superagonist, with or without combination broadly neutralizing antibodies (bNAbs), to induce HIV-1 control during analytic treatment interruption (ATI).
What is the current status of trial NCT04340596?
This trial is currently active not recruiting. It is a Phase 1 study. The enrollment target is 118 participants. The study started on 2021-05-21. Estimated completion is 2026-12-30.
What conditions does trial NCT04340596 study?
This clinical trial studies the following conditions: HIV Infection.
What interventions are being tested in trial NCT04340596?
The interventions under investigation include: VRC07-523LS (BIOLOGICAL), N-803 (IL-15 Superagonist) (BIOLOGICAL), 10-1074 (BIOLOGICAL).
Who is sponsoring clinical trial NCT04340596?
This trial is sponsored by National Institute of Allergy and Infectious Diseases (NIAID), which has 2,006 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT04340596 being conducted?
This trial has 14 study locations across Alabama, California, District of Columbia, Illinois, Massachusetts. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT04340596's enrollment target sits among peer trials
118 22nd of 73 higher than 52 of 73 other HIV Infection trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other HIV Infection trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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