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ClinicalTrials.gov 9 recruiting now official registry

HIV Infection clinical trials

9 of 74 indexed HIV Infection trials are currently recruiting.

74 US clinical trials · 9 currently recruiting

HIV Infection is the subject of 74 registered US clinical trials on ClinicalTrials.gov, 9 of them currently open to new participants. 15 are in Phase 3-4 (later-stage) and 32 in Phase 1-2 (earlier-stage). The most active sponsor is National Institute of Allergy and Infectious Diseases (NIAID), running 12 of these trials.

The research picture

HIV Infection has 74 registered US clinical trials, 9 of them open to new participants right now, about 12% of the total.

9
recruiting participants now
12%
of trials open to enrollment
15
in Phase 3–4 (later-stage)
12
top sponsor: National Institute of Allergy and Infectious Diseases (NIAID)
Phase 120Phase 212Phase 38Phase 47

Active & Recent Trials

74 total, page 2 of 2

COMPLETED Phase 1 42 participants

Use of Combined Antiretroviral Therapy to Determine Sites of Persistent HIV Infection

National Institute of Allergy and Infectious Diseases (NIAID)

NCT00001644

COMPLETED Phase 1 41 participants

A Study to Evaluate the Safety, Pharmacokinetics and Pharmacodynamics of ABBV-181 (Budigalimab) in Adult Participants With Human Immunodeficiency Virus (HIV)-1

AbbVie

NCT04223804

COMPLETED Phase 2 40 participants

The Role of Ampligen in Strategic Therapeutic Intervention (STI) of HAART

AIM ImmunoTech

NCT00035893

COMPLETED 38 participants

Immune and Viral Status of HIV-Infected Patients After Stopping Combination Antiretroviral Therapy

National Institute of Allergy and Infectious Diseases (NIAID)

NCT00001899

COMPLETED 38 participants

Evaluation of Barriers to Postpartum Care in HIV Infected Women

The University of Texas Health Science Center, Houston

NCT01853917

COMPLETED Phase 1 36 participants

Cabozantinib S-Malate in Treating Patients With Advanced Solid Tumors and Human Immunodeficiency Virus

National Cancer Institute (NCI)

NCT01822522

COMPLETED Phase 4 36 participants

Boosted Lexiva With Lovaza Adjunctive Therapy in Hypertriglyceridemic, HIV-Infected Subjects

Felizarta, Franco, M.D.

NCT01010399

COMPLETED 36 participants

Influence of Antiretroviral Regimen on Immune Reconstitution in the Female Genital Tract

University of Colorado, Denver

NCT01456962

COMPLETED Phase 2 36 participants

Pharmacodynamics of Intermittent IL-2 Infusions in HIV Seropositive Patients

National Institute of Allergy and Infectious Diseases (NIAID)

NCT00001474

COMPLETED Phase 1 31 participants

Phase I Protocol for the Evaluation of the Safety and Immunogenicity of Vaccination With Synthetic HIV Envelope Peptides in Patients With Early Human Immunodeficiency Virus Infection

National Cancer Institute (NCI)

NCT00001386

COMPLETED 30 participants

Physiologic Investigation of the Renin Angiotensin Aldosterone Axis in HIV

Massachusetts General Hospital

NCT01407237

COMPLETED Phase 1 29 participants

Study of the Safety and Pharmacokinetics of a Human Monoclonal Antibody, VRC-HIVMAB060-00-AB (VRC01), Administered Intravenously or Subcutaneously to Healthy Adults

National Institute of Allergy and Infectious Diseases (NIAID)

NCT01993706

COMPLETED Phase 2 28 participants

Therapeutic Intensification Plus Immunomodulation to Decrease the HIV-1 Viral Reservoir

Robert L. Murphy

NCT00976404

COMPLETED NA 25 participants

Androgen Effects in HIV-infected Women

Massachusetts General Hospital

NCT00095212

COMPLETED Phase 2 25 participants

Continued Antiretroviral Therapy With Abacavir, Amprenavir and Efavirenz

National Institute of Allergy and Infectious Diseases (NIAID)

NCT00001758

COMPLETED NA 24 participants

Technology-based Training Tool for PHAT Life

Oregon Research Behavioral Intervention Strategies

NCT05339412

COMPLETED Phase 1 20 participants

Pharmacokinetics of Antiretroviral Agents in HIV-1 Infected Pregnant Women

National Institute of Allergy and Infectious Diseases (NIAID)

NCT00006320

COMPLETED Phase 1 20 participants

The Effect of Milk Thistle on the Pharmacokinetics of Indinavir

National Institutes of Health Clinical Center (CC)

NCT00011635

COMPLETED Phase 1 19 participants

Phase 1 Dose Escalation Study of Autologous T-cells Genetically Modified at the CCR5 Gene by Zinc Finger Nucleases in HIV-Infected Patients

Sangamo Therapeutics

NCT01044654

COMPLETED Phase 1 18 participants

Evaluation of the Safety of a Polyvalent Virus in Healthy Adults

St. Jude Children's Research Hospital

NCT00187044

COMPLETED Phase 1 17 participants

Reducing the Residual Reservoir of HIV-1 Infected Cells in Patients Receiving Antiretroviral Therapy

Massachusetts General Hospital

NCT02471430

COMPLETED 12 participants

SNAP: Switching Nucleoside Analogues Protocol - Lipoatrophy and Mitochondrial Function

Northwestern University

NCT00225082

COMPLETED NA 7 participants

Immune Activation and Drug Absorption in HIV-Infected Patients

Drexel University

NCT01845298

COMPLETED 2 participants

IMPAACT P1107: Effects of Cord Blood Transplantation With CCR5Δ32 Donor Cells on HIV Persistence

International Maternal Pediatric Adolescent AIDS Clinical Trials Group

NCT02140944

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Phase Distribution

PhaseTrial count
Phase 1 20
Phase 2 12
Phase 3 8
Phase 4 7

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the HIV Infection Trial Landscape

74 indexed HIV Infection studies · 9 recruiting (12%).

Phase mix: 15 late (III/IV) vs 32 early (I/II).

Top sponsor: National Institute of Allergy and Infectious Diseases (NIAID) (12 trials), 9 others listed. 24 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for HIV Infection?

PlainTrial tracks 74 US clinical trials for HIV Infection, of which 9 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for HIV Infection?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.