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NCT00001243 · ClinicalTrials.gov registry record

Effects of HIV on the Development and Function of Bone Marrow Cells

A clinical trial of HIV Infection, sponsored by National Institute of Allergy and Infectious Diseases (NIAID).

Completed
Registry status
300
Enrollment target
1
Study location

NCT00001243 is a study of HIV Infection that has completed, run by National Institute of Allergy and Infectious Diseases (NIAID). The registered enrollment target is 300 participants, above the 239-participant average among 73 other HIV Infection trials with a reported enrollment target (26% higher). The trial reports 1 study location across 1 state.

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The verdict

NCT00001243, a study of HIV Infection, has completed, sponsored by National Institute of Allergy and Infectious Diseases (NIAID).

COMPLETED
Registry status
300 participants
Enrollment target
1
Study location

Study Summary

This study will examine the effects of HIV on bone marrow cells. Various types of cells from bone marrow will be studied to learn which cells become infected with HIV, what changes occur in the number of or growth patterns of the cells, what kinds of proteins the cells make in the presence or absence of HIV and whether the cells can function normally. HIV-infected and non-infected individuals 18 years of age and older may participate in this study. Participants will undergo the following procedures: * Blood draw: Blood will be drawn through a needle from a hand or arm vein. About 150 milliliters (10 tablespoons) will be collected each time. No more than 450 ml (30 tablespoons) will be taken over a 6-week period. * Bone marrow aspirate: Bone marrow will be drawn from the hipbone. For this procedure, a local anesthetic is injected in the skin over the hipbone. A small needle is put about 1/2-inch through the shell of the bone and about 3 to 4 teaspoons of marrow are drawn from the cavity into a syringe. White cells from marrow of uninfected individuals may be infected with HIV in the laboratory and grown over time for study. Alternatively, uninfected cells may be used as controls to compare with cells from HIV-infected individuals. White cells from marrow of HIV-infected individuals will be grown in the laboratory and studied in comparison with cells from uninfected individuals. Or, bone marrow cells may be injected into immune-deficient mice to try to develop an animal model for HIV infection. White blood cells will also be studied in the laboratory to learn how the immune system responds to HIV infection.

Conditions Studied

HIV Infection

Study Locations (1)

Maryland

  • National Institute of Allergy and Infectious Diseases (NIAID) - Bethesda

Trial Details

FieldValue
Enrollment Target 300 participants
Start Date 1989-02
Est. Completion 2005-12

Sponsor

National Institute of Allergy and Infectious Diseases (NIAID)

2,006 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT00001243

The ClinicalTrials.gov registry entry for NCT00001243 describes a study currently listed as completed, categorized as an unspecified phase. The registered enrollment target is 300 participants, a figure that helps gauge the scale of data the investigators plan to collect, above the 239-participant average among 73 other HIV Infection trials with a reported enrollment target (26% higher). The listed sponsor is National Institute of Allergy and Infectious Diseases (NIAID), which has 2,006 total studies on file at ClinicalTrials.gov.

The record links to 1 condition, with HIV Infection appearing as the primary indexed condition, and to 0 interventions.

NCT00001243 reports 1 study location spanning 1 distinct geographic area - top geographies include Maryland.

Frequently Asked Questions

What is clinical trial NCT00001243 about?

NCT00001243 is a clinical study titled "Effects of HIV on the Development and Function of Bone Marrow Cells". This study will examine the effects of HIV on bone marrow cells. Various types of cells from bone marrow will be studied to learn which cells become infected with HIV, what changes occur in the number of or growth patterns of the cells, what kinds of proteins the cells make in the presence or absenc...

What is the current status of trial NCT00001243?

This trial is currently completed. The enrollment target is 300 participants. The study started on 1989-02. Estimated completion is 2005-12.

What conditions does trial NCT00001243 study?

This clinical trial studies the following conditions: HIV Infection.

Who is sponsoring clinical trial NCT00001243?

This trial is sponsored by National Institute of Allergy and Infectious Diseases (NIAID), which has 2,006 total clinical trials registered on ClinicalTrials.gov.

Where is trial NCT00001243 being conducted?

This trial has 1 study location across Maryland. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

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Data sourced from official public datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page mirrors this trial's own ClinicalTrials.gov registry record, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.