Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.

2026 data Public-data reference. official source

Chronic Myelomonocytic Leukemia

Open-data reference.

74 US clinical trials · 30 currently recruiting

Active & Recent Trials

RECRUITING Phase 2 324 participants

Venetoclax to Improve Outcomes of Fractionated Busulfan Regimen in Patients With High-Risk AML and MDS

M.D. Anderson Cancer Center

NCT04708054

RECRUITING Phase 2 316 participants

A Multi-phase Study of ASTX030 (Azacitidine and Cedazuridine) in Myeloid Neoplasm Alone or in Combination With Venetoclax in AML (AZTOUND Study)

Taiho Oncology

NCT04256317

RECRUITING Phase 1 240 participants

Clinical Trial to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Tuspetinib (HM43239) in Patients With Relapsed or Refractory Acute Myeloid Leukemia

Aptose Biosciences

NCT03850574

RECRUITING Phase 2 124 participants

Dose-Expansion Study of Low Dose Post-Transplant Cyclophosphamide/Tacrolimus/Ruxolitinib for Graft-versus-Host Disease (GVHD) Prophylaxis in Myeloablative Allogeneic Peripheral Blood Stem Cell Transplantation

Hannah Choe, MD

NCT07249346

RECRUITING Phase 1 105 participants

A Phase 1 Study of STX-0712 in Patients With Advanced Hematological Malignancies (CMML and AML)

Solu Therapeutics

NCT06950034

RECRUITING Phase 2 100 participants

Personalized NK Cell Therapy in CBT

M.D. Anderson Cancer Center

NCT02727803

RECRUITING Phase 2 91 participants

Metabolically Optimized, Non-cytotoxic Low Dose Weekly Decitabine/Venetoclax in MDS and AML

Montefiore Medical Center

NCT05184842

RECRUITING Phase 2 80 participants

Ascorbic Acid and Chemotherapy for the Treatment of Relapsed or Refractory Lymphoma, CCUS, and Chronic Myelomonocytic Leukemia

Mayo Clinic

NCT03418038

RECRUITING Phase 2 76 participants

A Phase II, Open-Label, Study of Subcutaneous Canakinumab, an Anti-IL-1β Human Monoclonal Antibody, for Patients With Low or Int-1 Risk IPSS/IPSS-R Myelodysplastic Syndromes and Chronic Myelomonocytic Leukemia

M.D. Anderson Cancer Center

NCT04239157

RECRUITING Phase 1 75 participants

211^At-BC8-B10 Before Donor Stem Cell Transplant in Treating Patients With High-Risk Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia, Myelodysplastic Syndrome, or Mixed-Phenotype Acute Leukemia

Fred Hutchinson Cancer Center

NCT03128034

RECRUITING Phase 1 75 participants

Dual BET and CBP/p300 Inhibitor in Patients With Targeted Advanced Solid Tumors and Hematological Malignancies

Epigenetix

NCT05488548

RECRUITING Phase 2 63 participants

Two Step Haplo With Radiation Conditioning

Thomas Jefferson University

NCT05031897

RECRUITING Phase 2 63 participants

Azacitidine and Enasidenib in Treating Patients With IDH2-Mutant Myelodysplastic Syndrome

M.D. Anderson Cancer Center

NCT03383575

RECRUITING Phase 2 60 participants

Donor Stem Cell Transplant With Treosulfan, Fludarabine, and Total-Body Irradiation for the Treatment of Hematological Malignancies

Fred Hutchinson Cancer Center

NCT04195633

RECRUITING Phase 1 58 participants

Azacitidine and Quizartinib for the Treatment of Myelodysplastic Syndrome or Myelodysplastic/Myeloproliferative Neoplasm With FLT3 or CBL Mutations

M.D. Anderson Cancer Center

NCT04493138

RECRUITING Phase 1 52 participants

Axatilimab With or Without Azacitidine for the Treatment of Patients With Advanced Phase Myeloproliferative Neoplasms, Myeloproliferative Neoplasm/Myelodysplastic Syndrome Overlap or High Risk Chronic Myelomonocytic Leukemia

Uma Borate

NCT06523556

RECRUITING Phase 2 50 participants

Enasidenib and Azacitidine in Treating Patients With Recurrent or Refractory Acute Myeloid Leukemia and IDH2 Gene Mutation

M.D. Anderson Cancer Center

NCT03683433

RECRUITING Phase 2 45 participants

A Phase 2 Study Evaluating Olutasidenib in Combination With Hypomethylating Agents in Patients With IDH1-mutated Higher-risk Myelodysplastic Syndromes, Chronic Myelomonocytic Leukemia, or Advanced Myeloproliferative Neoplasm

M.D. Anderson Cancer Center

NCT06597734

RECRUITING Phase 1 44 participants

Study of Tagraxofusp for Post-Transplant Maintenance for Patients With CD 123+ AML, MDS, MF and CMML (HSCT 002)

Karen Ballen, MD

NCT05233618

RECRUITING Phase 2 35 participants

Vedolizumab Plus Post-transplant Cyclophosphamide and Short Course Tacrolimus for the Prevention of Graft Versus Host Disease in Patients Undergoing Allogeneic Hematopoietic Cell Transplantation After Reduced Intensity Conditioning

City of Hope Medical Center

NCT06815003

RECRUITING Phase 1 30 participants

211At-BC8-B10 Followed by Donor Stem Cell Transplant in Treating Patients With Relapsed or Refractory High-Risk Acute Leukemia or Myelodysplastic Syndrome

Fred Hutchinson Cancer Center

NCT03670966

RECRUITING Phase 1 30 participants

Chimeric Antigen Receptor T Cell Therapy Redirected to CD4 (CD4CAR)as a Second Line Treatment for Chronic Myelomonocytic Leukemia, CMML.

Huda Salman

NCT06071624

RECRUITING Phase 1 26 participants

Pacritinib in CMML

Douglas Tremblay

NCT06159491

RECRUITING Phase 2 25 participants

Eltrombopag as a Novel Therapeutic Approach for Low-risk MDS and CMML With TET2 Mutations

Abhay Singh, MD MPH

NCT06630221

RECRUITING Phase 1 24 participants

Pacritinib w/ Talazoparib in Pts w/ Myeloproliferative Neoplasms Unresponsive to JAK2 Inhibition

Fox Chase Cancer Center

NCT06218628

RECRUITING Early Phase 1 24 participants

Hyperbaric Oxygen Therapy and Allogeneic Peripheral Blood Stem Cell (PBSC) Transplant

Omar Aljitawi

NCT03964506

RECRUITING Phase 2 20 participants

ABBA CORD: dCBT w/ Abatacept for aGVHD Prophylaxis

Leland Metheny

NCT06680661

RECRUITING Phase 2 20 participants

Combination Chemotherapy (FLAG-Ida) Followed Immediately by Reduced-Intensity Total Body Radiation Therapy and Donor Hematopoietic Cell Transplant for the Treatment of Adults Age 60 and Older With Newly Diagnosed Adverse-Risk Acute Myeloid Leukemia or Other High-Grade Myeloid Cancer

Fred Hutchinson Cancer Center

NCT07046078

RECRUITING Phase 2 15 participants

A Phase 2 Study Evaluating Olutasidenib in Patients With IDH1-mutated Clonal Cytopenia of Undetermined Significance and Lower-risk Myelodysplastic/Syndromes/Chronic Myelomonocytic Leukemia.

M.D. Anderson Cancer Center

NCT06566742

RECRUITING Phase 1 15 participants

Olutasidenib for the Treatment of Patients With IDH1 Mutated AML, MDS or CMML After Donor Hematopoietic Cell Transplant

City of Hope Medical Center

NCT06543381

ACTIVE NOT RECRUITING Phase 2 313 participants

HLA-Mismatched Unrelated Donor Peripheral Blood Stem Cell Transplantation With Reduced Dose Post Transplantation Cyclophosphamide GvHD Prophylaxis

Center for International Blood and Marrow Transplant Research

NCT06001385

ACTIVE NOT RECRUITING Phase 2 282 participants

Azacitidine With or Without Lenalidomide or Vorinostat in Treating Patients With Higher-Risk Myelodysplastic Syndromes or Chronic Myelomonocytic Leukemia

National Cancer Institute (NCI)

NCT01522976

ACTIVE NOT RECRUITING Phase 3 247 participants

Lenalidomide With or Without Epoetin Alfa in Treating Patients With Myelodysplastic Syndrome and Anemia

National Cancer Institute (NCI)

NCT00843882

ACTIVE NOT RECRUITING Phase 1 181 participants

A Study to Assess Safety, Tolerability and Preliminary Efficacy of Bexmarilimab in Combination With Standard of Care in Patients With Hematological Malignancies

Faron Pharmaceuticals

NCT05428969

ACTIVE NOT RECRUITING Phase 1 135 participants

Vorinostat and Azacitidine in Treating Patients With Myelodysplastic Syndromes or Acute Myeloid Leukemia

National Cancer Institute (NCI)

NCT00392353

ACTIVE NOT RECRUITING Phase 2 132 participants

Venetoclax in Combination With ASTX727 for the Treatment of Chronic Myelomonocytic Leukemia and Other Myelodysplastic Syndrome/Myeloproliferative Neoplasm

National Cancer Institute (NCI)

NCT05600894

ACTIVE NOT RECRUITING Phase 2 72 participants

Clofarabine and Melphalan Before Donor Stem Cell Transplant in Treating Patients With Myelodysplasia, Acute Leukemia in Remission, or Chronic Myelomonocytic Leukemia

City of Hope Medical Center

NCT01885689

ACTIVE NOT RECRUITING Phase 1 72 participants

A Study of CFI-400945 With or Without Azacitidine in Patients With AML, MDS or CMML

Treadwell Therapeutics

NCT04730258

ACTIVE NOT RECRUITING Phase 1 64 participants

Phase I/II Study of Tagraxofusp in Combination With Decitabine for Patients With Myelomonocytic/Myeloproliferative Neoplasm and High Risk Myelodysplastic Syndromes

M.D. Anderson Cancer Center

NCT05038592

ACTIVE NOT RECRUITING Phase 1 52 participants

Venetoclax in Combination With ASTX727 for the Treatment of Treatment-Naive High-Risk Myelodysplastic Syndrome or Chronic Myelomonocytic Leukemia

M.D. Anderson Cancer Center

NCT04655755

ACTIVE NOT RECRUITING Phase 2 50 participants

Liposome-encapsulated Daunorubicin-Cytarabine and Gemtuzumab Ozogamicin in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia (AML) or High Risk Myelodysplastic Syndrome

M.D. Anderson Cancer Center

NCT03672539

ACTIVE NOT RECRUITING Phase 2 50 participants

Comparing the Addition of an Anti-Cancer Drug, Pomalidomide, to the Usual Chemotherapy Treatment (Daunorubicin and Cytarabine Liposome) in Newly Diagnosed Acute Myeloid Leukemia With Myelodysplastic Syndrome-Related Changes

National Cancer Institute (NCI)

NCT04802161

ACTIVE NOT RECRUITING Phase 1 40 participants

Azacitidine, Venetoclax, and Pevonedistat in Treating Patients With Newly Diagnosed Acute Myeloid Leukemia

M.D. Anderson Cancer Center

NCT03862157

ACTIVE NOT RECRUITING Phase 2 33 participants

Study of a Geriatric Assessment to Plan a Treatment Approach for Older People With Various Blood Disorders

Memorial Sloan Kettering Cancer Center

NCT04761770

ACTIVE NOT RECRUITING Phase 1 33 participants

Guadecitabine and Atezolizumab in Treating Patients With Advanced Myelodysplastic Syndrome or Chronic Myelomonocytic Leukemia That Is Refractory or Relapsed

University of Southern California

NCT02935361

ACTIVE NOT RECRUITING Phase 2 29 participants

Ruxolitinib for the Treatment of Chronic Myelomonocytic Leukemia (CMML): A Phase 2 Expansion

H. Lee Moffitt Cancer Center and Research Institute

NCT03722407

ACTIVE NOT RECRUITING Phase 2 25 participants

Topotecan Hydrochloride and Carboplatin With or Without Veliparib in Treating Advanced Myeloproliferative Disorders and Acute Myeloid Leukemia or Chronic Myelomonocytic Leukemia

National Cancer Institute (NCI)

NCT03289910

ACTIVE NOT RECRUITING Phase 1 25 participants

A Phase 1 Trial of CD25/Treg-depleted DLI Plus Ipilimumab for Myeloid Disease Relapse After Matched-HCT

Dana-Farber Cancer Institute

NCT03912064

ACTIVE NOT RECRUITING Phase 1 22 participants

NTX-301 in MDS/AML

University of Alabama at Birmingham

NCT04167917

ACTIVE NOT RECRUITING Phase 1 22 participants

Inqovi Maintenance Therapy in Myeloid Neoplasms

Massachusetts General Hospital

NCT04980404

ACTIVE NOT RECRUITING Phase 2 20 participants

Adding Itacitinib to Cyclophosphamide and Tacrolimus for the Prevention of Graft Versus Host Disease in Patients Undergoing Hematopoietic Stem Cell Transplants

City of Hope Medical Center

NCT05364762

COMPLETED Phase 3 880 participants

Combination Chemotherapy With or Without Bone Marrow Transplantation in Treating Children With Acute Myelogenous Leukemia or Myelodysplastic Syndrome

National Cancer Institute (NCI)

NCT00002798

COMPLETED Phase 3 226 participants

Supersaturated Calcium Phosphate Rinse in Preventing Oral Mucositis in Young Patients Undergoing Autologous or Donor Stem Cell Transplant

Children's Oncology Group

NCT01305200

COMPLETED Phase 2 150 participants

Nivolumab and Azacitidine With or Without Ipilimumab in Treating Patients With Refractory/Relapsed or Newly Diagnosed Acute Myeloid Leukemia

M.D. Anderson Cancer Center

NCT02397720

COMPLETED Phase 2 128 participants

Study of Three Different Schedules of Low-Dose Decitabine in Myelodysplastic Syndrome (MDS)

M.D. Anderson Cancer Center

NCT00067808

COMPLETED Phase 1 106 participants

Total-Body Irradiation and Fludarabine Phosphate Followed by Donor Peripheral Blood Stem Cell Transplant in Treating Patients With Hematologic Malignancies or Kidney Cancer

Fred Hutchinson Cancer Center

NCT00027820

COMPLETED Phase 1 82 participants

Tagraxofusp (SL-401) in Participants With Chronic Myelomonocytic Leukemia (CMML) and Myelofibrosis (MF)

Stemline Therapeutics

NCT02268253

COMPLETED Phase 2 74 participants

CCI-779 in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia, Myelodysplastic Syndromes, or Chronic Myelogenous Leukemia in Blastic Phase

National Cancer Institute (NCI)

NCT00084916

COMPLETED Phase 2 65 participants

Oral Clofarabine Study in Patients With Myelodysplastic Syndrome

M.D. Anderson Cancer Center

NCT00299156

COMPLETED Phase 1 65 participants

Tipifarnib in Treating Patients With Myelodysplastic Syndromes

National Cancer Institute (NCI)

NCT00005845

COMPLETED Phase 1 56 participants

Belinostat and Azacitidine in Treating Patients With Advanced Hematologic Cancers or Other Diseases

National Cancer Institute (NCI)

NCT00351975

COMPLETED Phase 2 52 participants

Phase II Study of Lenalidomide and Eltrombopag in Patients With Symptomatic Anemia

Albert Einstein College of Medicine

NCT01772420

COMPLETED 50 participants

Ascorbic Acid Levels in MDS, AML, and CMML Patients

Van Andel Research Institute

NCT03526666

COMPLETED Phase 2 50 participants

Chemotherapy in Treating Patients With Myelodysplastic Syndrome Before Donor Stem Cell Transplant

Fred Hutchinson Cancer Center

NCT01812252

COMPLETED Phase 2 50 participants

Clofarabine, Cytarabine, and Filgrastim in Treating Patients With Newly Diagnosed Acute Myeloid Leukemia, Advanced Myelodysplastic Syndrome, and/or Advanced Myeloproliferative Neoplasm

University of Washington

NCT01101880

COMPLETED Phase 2 43 participants

Azacitidine in Treating Patients With Relapsed Myelodysplastic Syndrome, Chronic Myelomonocytic Leukemia, or Acute Myeloid Leukemia Who Have Undergone Stem Cell Transplant

Fred Hutchinson Cancer Center

NCT01083706

COMPLETED Phase 1 37 participants

Biological Therapy in Treating Patients With Advanced Myelodysplastic Syndrome, Acute or Chronic Myeloid Leukemia, or Acute Lymphoblastic Leukemia Who Are Undergoing Stem Cell Transplantation

Fred Hutchinson Cancer Center

NCT00052520

COMPLETED Phase 1 35 participants

Chemotherapy Plus Sargramostim in Treating Patients With Refractory Myeloid Cancer

National Cancer Institute (NCI)

NCT00012376

COMPLETED Phase 2 34 participants

A Study of Gleevec in Patients With Idiopathic Myelofibrosis or Chronic Myelomonocytic Leukemia (CMML)

Dana-Farber Cancer Institute

NCT00136409

COMPLETED Phase 1 23 participants

IDH2 Inhibition Using Enasidenib as Maintenance Therapy for IDH2-mutant Myeloid Neoplasms Following Allogeneic Stem Cell Transplantation

Massachusetts General Hospital

NCT03515512

COMPLETED Phase 2 22 participants

Total Body Irradiation +/- Total Lymphoid Irradiation & Anti-Thymocyte Globulin in Non-myeloablative Hematopoietic Cell Transplantation

Stanford University

NCT03734601

COMPLETED Phase 1 21 participants

Ibrutinib and Azacitidine for Treatment of Higher Risk Myelodysplastic Syndrome

Brian Jonas

NCT02553941

COMPLETED Phase 2 12 participants

A Study of E7820 in People With Bone Marrow (Myeloid) Cancers

Memorial Sloan Kettering Cancer Center

NCT05024994

COMPLETED Phase 2 11 participants

A Study of 5-Azacitidine (Vidaza®) in Patients With Chronic Myelomonocytic Leukemia

University of Utah

NCT01350947

Phase Distribution

PhaseTrial count
Early Phase 1 31
Phase 2 39
Phase 3 3

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Chronic Myelomonocytic Leukemia Trial Landscape

ClinicalTrials.gov lists 74 US studies indexed under Chronic Myelomonocytic Leukemia, and 30 of those are currently open to recruitment — roughly 41% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

The phase distribution for Chronic Myelomonocytic Leukemia shows 3 late-stage studies (Phase 3 and Phase 4 combined) alongside 70 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

Top sponsor activity for Chronic Myelomonocytic Leukemia is led by M.D. Anderson Cancer Center with 15 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 74 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Chronic Myelomonocytic Leukemia?

PlainTrial tracks 74 US clinical trials for Chronic Myelomonocytic Leukemia, of which 30 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Chronic Myelomonocytic Leukemia?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2024 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

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