Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.

2026 data Public-data reference. official source

Gliosarcoma

Open-data reference.

35 US clinical trials · 6 currently recruiting

Active & Recent Trials

RECRUITING 120 participants

Improving Understanding of Glioblastoma Through Preservation of Biologically Active Brain Tissue

Baptist Health South Florida

NCT05756985

RECRUITING Phase 1 60 participants

Study of ABBV-637 or ABBV-155 With ERAS-801 for People With Glioblastoma

Memorial Sloan Kettering Cancer Center

NCT06934889

RECRUITING Phase 1 29 participants

Peposertib and Radiation Therapy, Followed by Temozolomide for the Treatment of Patients With Newly Diagnosed MGMT Unmethylated Glioblastoma or Gliosarcoma

M.D. Anderson Cancer Center

NCT04555577

RECRUITING Phase 1 28 participants

Study of Pembrolizumab and M032 (NSC 733972)

University of Alabama at Birmingham

NCT05084430

RECRUITING Phase 2 25 participants

Phase 2a Immune Modulation With Ultrasound for Newly Diagnosed Glioblastoma

Northwestern University

NCT05864534

RECRUITING Phase 1 24 participants

A Study of Temodar With Abexinostat (PCI-24781) for Patients With Recurrent Glioma

University of Nebraska

NCT05698524

ACTIVE NOT RECRUITING Phase 2 447 participants

Temozolomide With or Without Veliparib in Treating Patients With Newly Diagnosed Glioblastoma Multiforme

National Cancer Institute (NCI)

NCT02152982

ACTIVE NOT RECRUITING Phase 3 265 participants

Testing the Addition of the Chemotherapy Drug Lomustine (Gleostine) to the Usual Treatment (Temozolomide and Radiation Therapy) for Newly Diagnosed MGMT Methylated Glioblastoma

NRG Oncology

NCT05095376

ACTIVE NOT RECRUITING NA 146 participants

DSC-MRI in Measuring rCBV for Early Response to Bevacizumab in Patients With Recurrent Glioblastoma

ECOG-ACRIN Cancer Research Group

NCT03115333

ACTIVE NOT RECRUITING Phase 2 84 participants

ERC1671/GM-CSF/Cyclophosphamide for the Treatment of Glioblastoma Multiforme

Epitopoietic Research Corporation

NCT01903330

ACTIVE NOT RECRUITING Phase 2 66 participants

SurVaxM Vaccine Therapy and Temozolomide in Treating Patients With Newly Diagnosed Glioblastoma

Roswell Park Cancer Institute

NCT02455557

ACTIVE NOT RECRUITING Phase 1 57 participants

Ultrasound-based Blood-brain Barrier Opening and Albumin-bound Paclitaxel and Carboplatin for Recurrent Glioblastoma

Northwestern University

NCT04528680

ACTIVE NOT RECRUITING Phase 2 52 participants

Pembrolizumab and Standard Therapy in Treating Patients With Glioblastoma

Mayo Clinic

NCT03197506

ACTIVE NOT RECRUITING Phase 2 47 participants

Association of Peripheral Blood Immunologic Response to Therapeutic Response to Adjuvant Treatment With Immune Checkpoint Inhibition (ICI) in Patients With Newly Diagnosed Glioblastoma or Gliosarcoma

National Cancer Institute (NCI)

NCT04817254

ACTIVE NOT RECRUITING Phase 1 11 participants

Selinexor (KPT-330) in Combination With Temozolomide and Radiation Therapy in Patients With Newly Diagnosed Glioblastoma

National Cancer Institute (NCI)

NCT04216329

ACTIVE NOT RECRUITING Early Phase 1 4 participants

Natural Progesterone for the Treatment of Recurrent Glioblastoma

Emory University

NCT05091866

COMPLETED Phase 2 137 participants

Bevacizumab With or Without Trebananib in Treating Patients With Recurrent Brain Tumors

National Cancer Institute (NCI)

NCT01609790

COMPLETED Phase 2 127 participants

A Study of Rindopepimut/GM-CSF in Patients With Relapsed EGFRvIII-Positive Glioblastoma

Celldex Therapeutics

NCT01498328

COMPLETED Phase 2 125 participants

Avastin in Combination With Radiation (XRT) & Temozolomide, Followed by Avastin, Temozolomide and Irinotecan for Glioblastoma (GBM) and Gliosarcomas

Duke University

NCT00597402

COMPLETED Phase 2 112 participants

A Randomized Phase II Trial of Vandetanib (ZD6474) in Combination With Carboplatin Versus Carboplatin Alone Followed by Vandetanib Alone in Adults With Recurrent High-Grade Gliomas

National Cancer Institute (NCI)

NCT00995007

COMPLETED Phase 1 78 participants

Ph I Gleevec in Combo w RAD001 + Hydroxyurea for Pts w Recurrent MG

Annick Desjardins

NCT00613132

COMPLETED Phase 2 74 participants

Study of Bevacizumab Plus Temodar and Tarceva in Patients With Glioblastoma or Gliosarcoma

University of California, San Francis

NCT00525525

COMPLETED Phase 1 62 participants

Ph I Oral Topotecan and Temozolomide for Patients With Malignant Gliomas

Katy Peters

NCT00610571

COMPLETED Phase 2 56 participants

Phase II Avastin + Bortezomib for Patients With Recurrent Malignant Glioma

Duke University

NCT00611325

COMPLETED Phase 2 50 participants

Bevacizumab and Temozolomide in Treating Older Patients With Newly-Diagnosed Glioblastoma Multiforme or Gliosarcoma

Jonsson Comprehensive Cancer Center

NCT01149850

COMPLETED Phase 2 41 participants

Avastin/Temozolomide/Irinotecan for Unresectable/Multifocal Glioblastoma Multiforme

Katy Peters

NCT00979017

COMPLETED Phase 1 37 participants

PH I Addition of Farnesyl Transferase Inhibitor to Temozolomide for Pts w Gr 3 & 4 Malignant Gliomas

Duke University

NCT00612651

COMPLETED Phase 1 36 participants

A Phase I Study of Mebendazole for the Treatment of Pediatric Gliomas

Julie Krystal

NCT01837862

COMPLETED Phase 2 36 participants

AMG 102 and Avastin for Recurrent Malignant Glioma

Katy Peters

NCT01113398

COMPLETED Phase 1 29 participants

Lapatinib Ditosylate Before Surgery in Treating Patients With Recurrent High-Grade Glioma

National Cancer Institute (NCI)

NCT02101905

COMPLETED Phase 2 23 participants

Study of Lenalidomide and XRT in Patients With Newly Diagnosed Glioblastoma Multiforme

Dana-Farber Cancer Institute

NCT00165477

COMPLETED Phase 1 12 participants

BPM31510 in Treating Patients With Recurrent High-Grade Glioma Previously Treated With Bevacizumab

Seema Nagpal

NCT03020602

COMPLETED Phase 1 12 participants

Dose Escalation Study to Determine the Safety of IFN-Beta Gene Transfer in the Treatment of Grade III & Grade IV Gliomas

Biogen

NCT00031083

COMPLETED Phase 2 9 participants

GW572016 to Treat Recurrent Malignant Brain Tumors

National Cancer Institute (NCI)

NCT00107003

COMPLETED Phase 1 6 participants

Phase I Study of Cellular Immunotherapy for Recurrent/Refractory Malignant Glioma Using Intratumoral Infusions of GRm13Z40-2, An Allogeneic CD8+ Cytolitic T-Cell Line Genetically Modified to Express the IL 13-Zetakine and HyTK and to be Resistant to Glucocorticoids, in Combination With Interleukin-2

City of Hope Medical Center

NCT01082926

Phase Distribution

PhaseTrial count
Early Phase 1 15
Phase 2 17
Phase 3 1

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Gliosarcoma Trial Landscape

ClinicalTrials.gov lists 35 US studies indexed under Gliosarcoma, and 6 of those are currently open to recruitment — roughly 17% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

The phase distribution for Gliosarcoma shows 1 late-stage studies (Phase 3 and Phase 4 combined) alongside 32 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

Top sponsor activity for Gliosarcoma is led by National Cancer Institute (NCI) with 7 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 35 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Gliosarcoma?

PlainTrial tracks 35 US clinical trials for Gliosarcoma, of which 6 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Gliosarcoma?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2024 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →