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ClinicalTrials.gov 21 recruiting now official registry

Cirrhosis, Liver clinical trials

21 of 35 indexed Cirrhosis, Liver trials are currently recruiting.

35 US clinical trials · 21 currently recruiting

Cirrhosis, Liver is the subject of 35 registered US clinical trials on ClinicalTrials.gov, 21 of them currently open to new participants. 5 are in Phase 3-4 (later-stage) and 9 in Phase 1-2 (earlier-stage). The most active sponsor is The Cleveland Clinic, running 3 of these trials.

The research picture

Cirrhosis, Liver has 35 registered US clinical trials, 21 of them open to new participants right now, about 60% of the total.

21
recruiting participants now
60%
of trials open to enrollment
5
in Phase 3–4 (later-stage)
3
top sponsor: The Cleveland Clinic
Phase 14Phase 25Phase 33Phase 42

Active & Recent Trials

35 total, page 1 of 1

RECRUITING 400 participants

Measuring Patient Reported Needs in Outpatient Liver Disease Management

Indiana University

NCT07191886

RECRUITING 400 participants

Evaluation of Non-Invasive Tests for Metabolic Liver Disease

Foundation for the National Institutes of Health

NCT07122700

RECRUITING Phase 2 256 participants

Liver Cirrhosis Network Rosuvastatin Efficacy and Safety for Cirrhosis in the United States

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

NCT05832229

RECRUITING 240 participants

DELIVER Study in a Population With Clinical Suspicion of Liver Cirrhosis

Owlstone

NCT07035158

RECRUITING Phase 4 200 participants

Comparison Between 2-dose Versus 3-dose Regimens of Heplisav B in Cirrhosis

Mercy Medical Center

NCT04588077

RECRUITING NA 200 participants

LiverPAL: A Trial of Inpatient Palliative Care for Patients With Advanced Liver Disease

Massachusetts General Hospital

NCT05998330

RECRUITING Phase 2 200 participants

Liver Cancer Disparities in American Indian and Alaska Native Persons

University of Washington

NCT05304234

RECRUITING 146 participants

Development of 4D Flow MRI for Risk Stratification of Variceal Bleeding in Cirrhosis

University of Wisconsin, Madison

NCT04867954

RECRUITING NA 110 participants

Testing LiverWatch, a Home-Based Remote-Monitoring Intervention for Advanced Liver Disease

University of Pennsylvania

NCT06136221

RECRUITING Phase 1 74 participants

Single and Multiple Dose Escalation of PHIN-214 in Child-Pugh A and B Liver Cirrhotics

PharmaIN

NCT05490888

RECRUITING Phase 2 60 participants

EGCG for Hepatocellular Carcinoma Chemoprevention

University of Texas Southwestern Medical Center

NCT06015022

RECRUITING 60 participants

Changes in Glucose Tolerance in Patients With Cirrhosis Peri-Liver Transplant

University of Chicago

NCT06950788

RECRUITING NA 50 participants

Initial Resuscitation for Acute Kidney Injury in Cirrhosis

Massachusetts General Hospital

NCT06525623

RECRUITING NA 40 participants

Molecular Mechanism of Exercise in Cirrhosis

The Cleveland Clinic

NCT05982769

RECRUITING NA 32 participants

Leucine Enriched Essential Amino Acid Mixture to Reverse Muscle Loss in Cirrhosis

The Cleveland Clinic

NCT03208868

RECRUITING Phase 2 32 participants

Study of Tremelimumab and Durvalumab (MEDI4736) (T300+D) in Advanced Hepatocellular Carcinomas With Child-Pugh-B Cirrhosis

The University of Texas Health Science Center at San Antonio

NCT06526104

RECRUITING NA 24 participants

HMB Enriched Amino Acids to Reverse Muscle Loss in Cirrhosis

The Cleveland Clinic

NCT05166499

RECRUITING Phase 1 24 participants

The Microbiota Augmentation to Reestablish Commensal Organisms (MARCO) Trial

University of Chicago

NCT06871111

RECRUITING NA 20 participants

Transitional Care Program for Fluid Overload in Cirrhosis

Milton S. Hershey Medical Center

NCT06174272

RECRUITING Phase 2 10 participants

Danazol for Treatment of Cytopenias in Patients With Cirrhosis

University of Southern California

NCT04873102

RECRUITING Phase 1 8 participants

A Study of SIPLIZUMAB in AILD and LT Patients

Elizabeth C. Verna

NCT06455280

ACTIVE NOT RECRUITING 1,222 participants

Liver Cirrhosis Network Cohort Study

Northwestern University

NCT05740358

ACTIVE NOT RECRUITING 852 participants

ALTA TIPS: A 5-year Longitudinal Observational Study of Patients Undergoing TIPS Placement

University of Texas Southwestern Medical Center

NCT03973372

ACTIVE NOT RECRUITING 766 participants

Case-Control Study of the Glycotest™ HCC Panel Vs AFP for the Detection of Early-stage Hepatocellular Carcinoma

Glycotest

NCT03878550

ACTIVE NOT RECRUITING Phase 3 700 participants

A Phase 3 Study to Evaluate the Effect of Resmetirom on Clinical Outcomes in Patients With Well-compensated NASH Cirrhosis (MAESTRO-NASH-OUTCOMES)

Madrigal Pharmaceuticals

NCT05500222

ACTIVE NOT RECRUITING 533 participants

Prevalence of NAFLD and Advanced Fibrosis in Patients With Type 1 Diabetes

Joslin Diabetes Center

NCT04595474

ACTIVE NOT RECRUITING 52 participants

LiveSMART Trial to Prevent Falls in Patients With Cirrhosis - Supplementary Study

University of Michigan

NCT07140120

ACTIVE NOT RECRUITING NA 49 participants

Liver Cancer Prevention Randomized Control Trial

M.D. Anderson Cancer Center

NCT05196867

ACTIVE NOT RECRUITING NA 40 participants

Safety and Efficacy of Ketogenic Diet for Promoting Weight Loss in Obese Individuals With Compensated NASH Cirrhosis

Indiana University

NCT04383951

COMPLETED Phase 3 1,050 participants

Long Term Interferon for Patients Who Did Not Clear Hepatitis C Virus With Standard Treatment

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

NCT00006164

COMPLETED Phase 3 230 participants

LiveSMART Trial to Prevent Falls in Patients With Cirrhosis

University of Michigan

NCT05794555

COMPLETED Phase 1 87 participants

Phase 1 Study to Evaluate the Pharmacokinetics, Safety, and Tolerability of Multiple Oral Doses of MGL-3196 in Subjects With Varying Degrees of Hepatic Impairment and Healthy Matched Control Subjects

Madrigal Pharmaceuticals

NCT04643795

COMPLETED Phase 4 32 participants

Prophylactic Antibiotics in Admitted Cirrhotics

Beth Israel Deaconess Medical Center

NCT04218695

COMPLETED NA 25 participants

LiverPAL: A Pilot Study of Inpatient Palliative Care for Patients With Advanced Liver Disease

Massachusetts General Hospital

NCT04953143

COMPLETED 8 participants

TIPS Plus Transvenous Obliteration for Gastric Varices

University of Illinois at Chicago

NCT04044248

Phase Distribution

PhaseTrial count
Phase 1 4
Phase 2 5
Phase 3 3
Phase 4 2

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Cirrhosis, Liver Trial Landscape

35 indexed Cirrhosis, Liver studies · 21 recruiting (60%).

Phase mix: 5 late (III/IV) vs 9 early (I/II).

Top sponsor: The Cleveland Clinic (3 trials), 9 others listed. 35 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Cirrhosis, Liver?

PlainTrial tracks 35 US clinical trials for Cirrhosis, Liver, of which 21 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Cirrhosis, Liver?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.