Celldex Therapeutics
Celldex Therapeutics sponsors 42 registered US clinical trials on ClinicalTrials.gov, 3 of them currently recruiting, and 25 completed. 5 of these trials are in Phase 3-4 (later-stage) and 37 in Phase 1-2 (earlier-stage). The most-studied condition in this pipeline is Chronic Spontaneous Urticaria, with 3 trials.
Trial Pipeline
42 total, page 1 of 1
A Study of CDX-622 in Participants With Mild to Moderate Asthma
NCT07330778
A Study to Investigate Efficacy, Safety and Tolerability of Barzolvolimab Versus Placebo in Adults With Cold Induced Urticaria and Symptomatic Dermographism Inadequately Controlled by H1-antihistamines (EMBARQ - ColdU and SD)
NCT07266402
Long-term Efficacy and Safety Extension (LTE) Study of Barzolvolimab in Participants With Chronic Spontaneous Urticaria
NCT07256392
A Study of Barzolvolimab in Patients With Atopic Dermatitis
NCT06727552
A Phase I Study of CDX-622
NCT06650761
A Phase 3 Study of Barzolvolimab in Participants With Chronic Spontaneous Urticaria (CSU)
NCT06455202
A Phase 3 Study of Barzolvolimab in Participants With Chronic Spontaneous Urticaria
NCT06445023
A Study of Barzolvolimab in Patients With Prurigo Nodularis
NCT06366750
A Study of CDX-0159 in Patients With Eosinophilic Esophagitis
NCT05774184
A Study of CDX-585 in Patients With Advanced Malignancies
NCT05788484
A Study of CDX-0159 in Patients With Chronic Inducible Urticaria
NCT05405660
A Phase 2 Study of CDX-0159 in Patients With Chronic Spontaneous Urticaria
NCT05368285
A Study of CDX-0159 in Patients With Prurigo Nodularis
NCT04944862
A Phase 1 Study of Subcutaneous CDX-0159 in Healthy Subjects
NCT05031624
A Study of CDX-0159 in Patients With Chronic Spontaneous Urticaria
NCT04538794
A Study of the PD-L1xCD27 Bispecific Antibody CDX-527 in Patients With Advanced Malignancies
NCT04440943
A Phase 1 Study of CDX-0159
NCT04146129
A Study of CDX-3379 and Cetuximab and in Patients With Advanced Head and Neck Squamous Cell Carcinoma
NCT03254927
A Study of CDX-1140 (CD40) as Monotherapy or in Combination in Patients With Advanced Malignancies
NCT03329950
A Dose Escalation, Safety and Activity Study of CDX-014 in Patients With Renal Cell Carcinoma and Ovarian Clear Cell Carcinoma
NCT02837991
A Study to Evaluate the Safety and Pharmacokinetics of CDX-0158 in Adult Patients With Advanced Solid Tumors
NCT02642016
A Window of Opportunity Study of KTN3379 in Surgically Resectable Head and Neck Cancer Patients
NCT02473731
A Study of Varlilumab and Atezolizumab in Patients With Advanced Cancer
NCT02543645
Enhancing Radioiodine Incorporation Into BRAF Mutant Thyroid Cancers With the Combination of Vemurafenib and KTN3379
NCT02456701
A Study of Varlilumab (Anti-CD27) and Sunitinib in Patients With Metastatic Clear Cell Renal Cell Carcinoma
NCT02386111
A Study of Varlilumab (Anti-CD27) and Ipilimumab and CDX-1401 in Patients With Unresectable Stage III or IV Melanoma
NCT02413827
A Dose Escalation and Cohort Expansion Study of Anti-CD27 (Varlilumab) and Anti-PD-1 (Nivolumab) in Advanced Refractory Solid Tumors
NCT02335918
A Study of Glembatumumab Vedotin as Monotherapy or in Combination With Immunotherapies in Patients With Advanced Melanoma
NCT02302339
A Safety and Tolerability Study of CDX-301 With or Without Plerixafor for Stem Cell Mobilization in Matched Related Allogeneic Donor/Recipient Sibling Transplant Pairs
NCT02200380
A Phase 1 Study to Evaluate the Safety and Pharmacokinetics of KTN3379 in Adult Subjects With Advanced Tumors
NCT02014909
Study of Glembatumumab Vedotin (CDX-011) in Patients With Metastatic, gpNMB Over-Expressing, Triple Negative Breast Cancer
NCT01997333
Clinical Trial of CDX-1135 in Pediatric and Adult Patients With Dense Deposit Disease
NCT01791686
A Study of Rindopepimut/GM-CSF in Patients With Relapsed EGFRvIII-Positive Glioblastoma
NCT01498328
Phase III Study of Rindopepimut/GM-CSF in Patients With Newly Diagnosed Glioblastoma
NCT01480479
A Study of CDX-1127 (Varlilumab) in Patients With Select Solid Tumor Types or Hematologic Cancers
NCT01460134
A Study to Evaluate CDX-301 (rhuFlt3L) in Healthy Volunteers
NCT01465139
A Study of CDX-011 (CR011-vcMMAE) in Patients With Advanced GPNMB-expressing Breast Cancer
NCT01156753
A Study of the CDX-1307 Vaccine Regimen in Patients With Newly Diagnosed Muscle-Invasive Bladder Cancer (The "N-ABLE" Study)
NCT01094496
A Study of CDX-1401 in Patients With Malignancies Known to Express NY-ESO-1
NCT00948961
Phase II Study of Rindopepimut (CDX-110) in Patients With Glioblastoma Multiforme
NCT00458601
Phase I Study of CDX-1307, hCG-B Vaccine, for Patients With Incurable, Locally Advanced or Metastatic Breast, Colorectal, Pancreatic, Bladder or Ovarian Cancer
NCT00648102
A Study of CDX-1307, in Patients With Incurable Breast, Colorectal, Pancreatic, Ovarian or Bladder Cancer (CDX 1307-01)
NCT00709462
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 24 |
| Phase 2 | 13 |
| Phase 3 | 5 |
Therapeutic Areas
What the Pipeline for Celldex Therapeutics Shows
According to the ClinicalTrials.gov registry, Celldex Therapeutics is linked to 42 US clinical trials across every stage of research activity. Of those, 3 studies are currently recruiting, about 7% of the sponsor's indexed portfolio, and 25 are already marked complete, representing roughly 60% of the total.
The phase mix for Celldex Therapeutics reports 5 late-stage studies (Phase 3 and Phase 4 combined) and 37 earlier-phase studies (Phase 1 and Phase 2).
The top therapeutic focus area indexed for Celldex Therapeutics is Chronic Spontaneous Urticaria with 3 linked trials, and 9 other condition areas appear in the top list above.
How to read these pipeline numbers
Recruiting share is one of the more practical signals here: it reflects how much of a sponsor's research is presently open to new participants, while the completed share indicates the depth of finished work that has already contributed registry results. Both counts come directly from the public ClinicalTrials.gov dataset and are refreshed on the registry side; this page mirrors the latest data pull without altering it.
A portfolio weighted toward Phase 3 usually reflects an organization advancing candidates toward regulatory review, where the research centers on comparative efficacy and broader safety across larger populations. A heavier Phase 1 and Phase 2 tilt generally indicates exploratory work, safety, dosing, and early signal detection, and is common among research-forward sponsors that seed many early programs. Phase 4 entries, when present, track interventions already in real-world use and typically focus on long-term safety, effectiveness across subgroups, or formulation comparisons.
That distribution is a quick read of where the organization concentrates its research attention; it does not imply product availability, market share, or any clinical endorsement. All numbers on this page come from ClinicalTrials.gov maintained by the National Library of Medicine, and counts can shift as new studies are registered or existing ones update their status. This information is provided for reference and educational purposes only, not as medical, investment, or regulatory advice, verify current details directly with ClinicalTrials.gov before relying on any figure here.
Read our methodology - how this data is sourced, computed, and verified.
Related
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial from this sponsor, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.