Celldex Therapeutics

42 total trials 3 currently recruiting 25 completed

Celldex Therapeutics sponsors 42 registered US clinical trials on ClinicalTrials.gov, 3 of them currently recruiting, and 25 completed. 5 of these trials are in Phase 3-4 (later-stage) and 37 in Phase 1-2 (earlier-stage). The most-studied condition in this pipeline is Chronic Spontaneous Urticaria, with 3 trials.

Trial Pipeline

42 total, page 1 of 1

RECRUITING Phase 1

A Study of CDX-622 in Participants With Mild to Moderate Asthma

NCT07330778

RECRUITING Phase 3

A Study to Investigate Efficacy, Safety and Tolerability of Barzolvolimab Versus Placebo in Adults With Cold Induced Urticaria and Symptomatic Dermographism Inadequately Controlled by H1-antihistamines (EMBARQ - ColdU and SD)

NCT07266402

RECRUITING Phase 3

Long-term Efficacy and Safety Extension (LTE) Study of Barzolvolimab in Participants With Chronic Spontaneous Urticaria

NCT07256392

ACTIVE NOT RECRUITING Phase 2

A Study of Barzolvolimab in Patients With Atopic Dermatitis

NCT06727552

ACTIVE NOT RECRUITING Phase 1

A Phase I Study of CDX-622

NCT06650761

ACTIVE NOT RECRUITING Phase 3

A Phase 3 Study of Barzolvolimab in Participants With Chronic Spontaneous Urticaria (CSU)

NCT06455202

ACTIVE NOT RECRUITING Phase 3

A Phase 3 Study of Barzolvolimab in Participants With Chronic Spontaneous Urticaria

NCT06445023

ACTIVE NOT RECRUITING Phase 2

A Study of Barzolvolimab in Patients With Prurigo Nodularis

NCT06366750

COMPLETED Phase 2

A Study of CDX-0159 in Patients With Eosinophilic Esophagitis

NCT05774184

COMPLETED Phase 1

A Study of CDX-585 in Patients With Advanced Malignancies

NCT05788484

COMPLETED Phase 2

A Study of CDX-0159 in Patients With Chronic Inducible Urticaria

NCT05405660

COMPLETED Phase 2

A Phase 2 Study of CDX-0159 in Patients With Chronic Spontaneous Urticaria

NCT05368285

COMPLETED Phase 1

A Study of CDX-0159 in Patients With Prurigo Nodularis

NCT04944862

COMPLETED Phase 1

A Phase 1 Study of Subcutaneous CDX-0159 in Healthy Subjects

NCT05031624

COMPLETED Phase 1

A Study of CDX-0159 in Patients With Chronic Spontaneous Urticaria

NCT04538794

COMPLETED Phase 1

A Study of the PD-L1xCD27 Bispecific Antibody CDX-527 in Patients With Advanced Malignancies

NCT04440943

COMPLETED Phase 1

A Phase 1 Study of CDX-0159

NCT04146129

TERMINATED Phase 2

A Study of CDX-3379 and Cetuximab and in Patients With Advanced Head and Neck Squamous Cell Carcinoma

NCT03254927

COMPLETED Phase 1

A Study of CDX-1140 (CD40) as Monotherapy or in Combination in Patients With Advanced Malignancies

NCT03329950

TERMINATED Phase 1

A Dose Escalation, Safety and Activity Study of CDX-014 in Patients With Renal Cell Carcinoma and Ovarian Clear Cell Carcinoma

NCT02837991

COMPLETED Phase 1

A Study to Evaluate the Safety and Pharmacokinetics of CDX-0158 in Adult Patients With Advanced Solid Tumors

NCT02642016

COMPLETED Phase 1

A Window of Opportunity Study of KTN3379 in Surgically Resectable Head and Neck Cancer Patients

NCT02473731

TERMINATED Phase 1

A Study of Varlilumab and Atezolizumab in Patients With Advanced Cancer

NCT02543645

COMPLETED Phase 1

Enhancing Radioiodine Incorporation Into BRAF Mutant Thyroid Cancers With the Combination of Vemurafenib and KTN3379

NCT02456701

TERMINATED Phase 1

A Study of Varlilumab (Anti-CD27) and Sunitinib in Patients With Metastatic Clear Cell Renal Cell Carcinoma

NCT02386111

TERMINATED Phase 1

A Study of Varlilumab (Anti-CD27) and Ipilimumab and CDX-1401 in Patients With Unresectable Stage III or IV Melanoma

NCT02413827

COMPLETED Phase 1

A Dose Escalation and Cohort Expansion Study of Anti-CD27 (Varlilumab) and Anti-PD-1 (Nivolumab) in Advanced Refractory Solid Tumors

NCT02335918

TERMINATED Phase 2

A Study of Glembatumumab Vedotin as Monotherapy or in Combination With Immunotherapies in Patients With Advanced Melanoma

NCT02302339

TERMINATED Phase 2

A Safety and Tolerability Study of CDX-301 With or Without Plerixafor for Stem Cell Mobilization in Matched Related Allogeneic Donor/Recipient Sibling Transplant Pairs

NCT02200380

COMPLETED Phase 1

A Phase 1 Study to Evaluate the Safety and Pharmacokinetics of KTN3379 in Adult Subjects With Advanced Tumors

NCT02014909

COMPLETED Phase 2

Study of Glembatumumab Vedotin (CDX-011) in Patients With Metastatic, gpNMB Over-Expressing, Triple Negative Breast Cancer

NCT01997333

TERMINATED Phase 1

Clinical Trial of CDX-1135 in Pediatric and Adult Patients With Dense Deposit Disease

NCT01791686

COMPLETED Phase 2

A Study of Rindopepimut/GM-CSF in Patients With Relapsed EGFRvIII-Positive Glioblastoma

NCT01498328

COMPLETED Phase 3

Phase III Study of Rindopepimut/GM-CSF in Patients With Newly Diagnosed Glioblastoma

NCT01480479

COMPLETED Phase 1

A Study of CDX-1127 (Varlilumab) in Patients With Select Solid Tumor Types or Hematologic Cancers

NCT01460134

COMPLETED Phase 1

A Study to Evaluate CDX-301 (rhuFlt3L) in Healthy Volunteers

NCT01465139

COMPLETED Phase 2

A Study of CDX-011 (CR011-vcMMAE) in Patients With Advanced GPNMB-expressing Breast Cancer

NCT01156753

TERMINATED Phase 2

A Study of the CDX-1307 Vaccine Regimen in Patients With Newly Diagnosed Muscle-Invasive Bladder Cancer (The "N-ABLE" Study)

NCT01094496

COMPLETED Phase 1

A Study of CDX-1401 in Patients With Malignancies Known to Express NY-ESO-1

NCT00948961

COMPLETED Phase 2

Phase II Study of Rindopepimut (CDX-110) in Patients With Glioblastoma Multiforme

NCT00458601

COMPLETED Phase 1

Phase I Study of CDX-1307, hCG-B Vaccine, for Patients With Incurable, Locally Advanced or Metastatic Breast, Colorectal, Pancreatic, Bladder or Ovarian Cancer

NCT00648102

COMPLETED Phase 1

A Study of CDX-1307, in Patients With Incurable Breast, Colorectal, Pancreatic, Ovarian or Bladder Cancer (CDX 1307-01)

NCT00709462

What the Pipeline for Celldex Therapeutics Shows

According to the ClinicalTrials.gov registry, Celldex Therapeutics is linked to 42 US clinical trials across every stage of research activity. Of those, 3 studies are currently recruiting, about 7% of the sponsor's indexed portfolio, and 25 are already marked complete, representing roughly 60% of the total.

The phase mix for Celldex Therapeutics reports 5 late-stage studies (Phase 3 and Phase 4 combined) and 37 earlier-phase studies (Phase 1 and Phase 2).

The top therapeutic focus area indexed for Celldex Therapeutics is Chronic Spontaneous Urticaria with 3 linked trials, and 9 other condition areas appear in the top list above.

How to read these pipeline numbers

Recruiting share is one of the more practical signals here: it reflects how much of a sponsor's research is presently open to new participants, while the completed share indicates the depth of finished work that has already contributed registry results. Both counts come directly from the public ClinicalTrials.gov dataset and are refreshed on the registry side; this page mirrors the latest data pull without altering it.

A portfolio weighted toward Phase 3 usually reflects an organization advancing candidates toward regulatory review, where the research centers on comparative efficacy and broader safety across larger populations. A heavier Phase 1 and Phase 2 tilt generally indicates exploratory work, safety, dosing, and early signal detection, and is common among research-forward sponsors that seed many early programs. Phase 4 entries, when present, track interventions already in real-world use and typically focus on long-term safety, effectiveness across subgroups, or formulation comparisons.

That distribution is a quick read of where the organization concentrates its research attention; it does not imply product availability, market share, or any clinical endorsement. All numbers on this page come from ClinicalTrials.gov maintained by the National Library of Medicine, and counts can shift as new studies are registered or existing ones update their status. This information is provided for reference and educational purposes only, not as medical, investment, or regulatory advice, verify current details directly with ClinicalTrials.gov before relying on any figure here.

Data sourced from official public datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial from this sponsor, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.