Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
DSC-MRI in Measuring rCBV for Early Response to Bevacizumab in Patients With Recurrent Glioblastoma
NCT03115333 · View on ClinicalTrials.gov ↗
Study Summary
This phase II trial studies how well dynamic susceptibility contrast-enhanced magnetic resonance imaging (DSC-MRI) works in measuring relative cerebral blood volume (rCBV) for early response to bevacizumab in patients with glioblastoma that has come back. DSC-MRI may help evaluate changes in the blood vessels within the cancer to determine a patient?s response to treatment.
Conditions Studied
Interventions
- DIAGNOSTIC_TEST Dynamic Susceptibility Contrast-Enhanced Magnetic Resonance Imaging
Study Locations (20)
Florida
- Boca Raton Regional Hospital — Boca Raton
- Baptist MD Anderson Cancer Center — Jacksonville
- Mayo Clinic in Florida — Jacksonville
- Moffitt Cancer Center-International Plaza — Tampa
- Moffitt Cancer Center - McKinley Campus — Tampa
- Moffitt Cancer Center — Tampa
California
- Eden Hospital Medical Center — Castro Valley
- Loma Linda University Medical Center — Loma Linda
- USC / Norris Comprehensive Cancer Center — Los Angeles
- UC Irvine Health/Chao Family Comprehensive Cancer Center — Orange
- VA Palo Alto Health Care System — Palo Alto
Arizona
- Saint Joseph's Hospital and Medical Center — Phoenix
- Mayo Clinic Hospital — Phoenix
- Mayo Clinic in Arizona — Scottsdale
Georgia
- Emory University Hospital/Winship Cancer Institute — Atlanta
- Northside Hospital — Atlanta
- Northside Hospital-Forsyth — Cumming
Indiana
- Indiana University/Melvin and Bren Simon Cancer Center — Indianapolis
- IU Health Methodist Hospital — Indianapolis
Kentucky
- Baptist Health Lexington — Lexington
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 146 participants |
| Start Date | 2017-07-25 |
| Est. Completion | 2027-05-07 |
| Phase | NA |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT03115333
The ClinicalTrials.gov registry entry for NCT03115333 describes a study currently listed as active not recruiting. It is categorized as NA, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 146 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is ECOG-ACRIN Cancer Research Group, which has 52 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 2 conditions, with Recurrent Glioblastoma appearing as the primary indexed condition, and to 1 intervention — of which Dynamic Susceptibility Contrast-Enhanced Magnetic Resonance Imaging is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT03115333 reports 20 study locations spanning 6 distinct geographic areas — top geographies include Florida, California, Arizona. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT03115333 about?
NCT03115333 is a clinical study titled "DSC-MRI in Measuring rCBV for Early Response to Bevacizumab in Patients With Recurrent Glioblastoma". This phase II trial studies how well dynamic susceptibility contrast-enhanced magnetic resonance imaging (DSC-MRI) works in measuring relative cerebral blood volume (rCBV) for early response to bevacizumab in patients with glioblastoma that has come back. DSC-MRI may help evaluate changes in the blo...
What is the current status of trial NCT03115333?
This trial is currently active not recruiting. It is a NA study. The enrollment target is 146 participants. The study started on 2017-07-25. Estimated completion is 2027-05-07.
What conditions does trial NCT03115333 study?
This clinical trial studies the following conditions: Recurrent Glioblastoma, Gliosarcoma. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT03115333?
The interventions under investigation include: Dynamic Susceptibility Contrast-Enhanced Magnetic Resonance Imaging (DIAGNOSTIC_TEST). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT03115333?
This trial is sponsored by ECOG-ACRIN Cancer Research Group, which has 52 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT03115333 being conducted?
This trial has 20 study locations across Arizona, California, Florida, Georgia, Indiana. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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